FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007403234> ?p ?o ?g. }

• W2007403234 endingPage "S6" @default.
• W2007403234 startingPage "S2" @default.
• W2007403234 abstract "Fluoroquinolones are the most attractive agents for prophylactic use in neutropenic cancer patients, due to their broad antimicrobial spectrum, high concentration in the faeces, systemic bactericidal activity, uncommon emergence of resistant strains and good tolerability. They have proved to be more effective than placebo, oral non-absorbable antibiotics or cotrimoxazole in the prevention of Gram-negative infections. In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies. The greater efficacy may be related to its better systemic or greater antibacterial activity. The potential problems related to the prophylactic use of fluoroquinolones are the increasing prevalence of Gram-positive infections caused by streptococci and coagulase-negative staphylococci; the reported emergence and nosocomial spread of resistant strains, especially among coagulase-negative staphylococci; the lack of their usefulness as empirical therapy in febrile neutropenic patients. Fluoroquinolones are today the better choice for preventing Gram-negative infections in neutropenic patients and ciprofloxacin should probably be preferred. More information on their efficacy and their relationship to the overall susceptibility of micro-organisms in patients with cancer would be valuable, and careful monitoring of patients treated with these drugs is therefore warranted. Fluoroquinolones are the most attractive agents for prophylactic use in neutropenic cancer patients, due to their broad antimicrobial spectrum, high concentration in the faeces, systemic bactericidal activity, uncommon emergence of resistant strains and good tolerability. They have proved to be more effective than placebo, oral non-absorbable antibiotics or cotrimoxazole in the prevention of Gram-negative infections. In a prospective, randomised multicentre study performed by the GIMEMA infection program, ciprofloxacin was demonstrated to be more effective than norfloxacin for the reduction of febrile episodes, use of systemic antibiotics, and Gram-negative infections in neutropenic patients with haematological malignancies. The greater efficacy may be related to its better systemic or greater antibacterial activity. The potential problems related to the prophylactic use of fluoroquinolones are the increasing prevalence of Gram-positive infections caused by streptococci and coagulase-negative staphylococci; the reported emergence and nosocomial spread of resistant strains, especially among coagulase-negative staphylococci; the lack of their usefulness as empirical therapy in febrile neutropenic patients. Fluoroquinolones are today the better choice for preventing Gram-negative infections in neutropenic patients and ciprofloxacin should probably be preferred. More information on their efficacy and their relationship to the overall susceptibility of micro-organisms in patients with cancer would be valuable, and careful monitoring of patients treated with these drugs is therefore warranted." @default.
• W2007403234 created "2016-06-24" @default.
• W2007403234 creator A5044157939 @default.
• W2007403234 creator A5088624316 @default.
• W2007403234 date "1993-01-01" @default.
• W2007403234 modified "2023-10-14" @default.
• W2007403234 title "The new fluorinated quinolones for antimicrobial prophylaxis in neutropenic cancer patients" @default.
• W2007403234 cites W1521735444 @default.
• W2007403234 cites W1602742100 @default.
• W2007403234 cites W19307154 @default.
• W2007403234 cites W2013964937 @default.
• W2007403234 cites W2018263896 @default.
• W2007403234 cites W2029377912 @default.
• W2007403234 cites W2033964316 @default.
• W2007403234 cites W2049024817 @default.
• W2007403234 cites W2053352564 @default.
• W2007403234 cites W2059107332 @default.
• W2007403234 cites W2063173017 @default.
• W2007403234 cites W2067400614 @default.
• W2007403234 cites W2070605487 @default.
• W2007403234 cites W2072977890 @default.
• W2007403234 cites W2078180921 @default.
• W2007403234 cites W2080971190 @default.
• W2007403234 cites W2085963147 @default.
• W2007403234 cites W2094614764 @default.
• W2007403234 cites W2098835431 @default.
• W2007403234 cites W2123304642 @default.
• W2007403234 cites W2126589309 @default.
• W2007403234 cites W2319438985 @default.
• W2007403234 cites W4238512033 @default.
• W2007403234 cites W4243072495 @default.
• W2007403234 cites W54250152 @default.
• W2007403234 doi "https://doi.org/10.1016/s0959-8049(05)80252-7" @default.
• W2007403234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8427721" @default.
• W2007403234 hasPublicationYear "1993" @default.
• W2007403234 type Work @default.
• W2007403234 sameAs 2007403234 @default.
• W2007403234 citedByCount "24" @default.
• W2007403234 countsByYear W20074032342012 @default.
• W2007403234 countsByYear W20074032342017 @default.
• W2007403234 crossrefType "journal-article" @default.
• W2007403234 hasAuthorship W2007403234A5044157939 @default.
• W2007403234 hasAuthorship W2007403234A5088624316 @default.
• W2007403234 hasConcept C126322002 @default.
• W2007403234 hasConcept C177713679 @default.
• W2007403234 hasConcept C197934379 @default.
• W2007403234 hasConcept C2776694085 @default.
• W2007403234 hasConcept C2777063308 @default.
• W2007403234 hasConcept C2778375690 @default.
• W2007403234 hasConcept C2778512257 @default.
• W2007403234 hasConcept C2778850193 @default.
• W2007403234 hasConcept C4937899 @default.
• W2007403234 hasConcept C501593827 @default.
• W2007403234 hasConcept C71924100 @default.
• W2007403234 hasConcept C86803240 @default.
• W2007403234 hasConcept C89423630 @default.
• W2007403234 hasConceptScore W2007403234C126322002 @default.
• W2007403234 hasConceptScore W2007403234C177713679 @default.
• W2007403234 hasConceptScore W2007403234C197934379 @default.
• W2007403234 hasConceptScore W2007403234C2776694085 @default.
• W2007403234 hasConceptScore W2007403234C2777063308 @default.
• W2007403234 hasConceptScore W2007403234C2778375690 @default.
• W2007403234 hasConceptScore W2007403234C2778512257 @default.
• W2007403234 hasConceptScore W2007403234C2778850193 @default.
• W2007403234 hasConceptScore W2007403234C4937899 @default.
• W2007403234 hasConceptScore W2007403234C501593827 @default.
• W2007403234 hasConceptScore W2007403234C71924100 @default.
• W2007403234 hasConceptScore W2007403234C86803240 @default.
• W2007403234 hasConceptScore W2007403234C89423630 @default.
• W2007403234 hasLocation W20074032341 @default.
• W2007403234 hasLocation W20074032342 @default.
• W2007403234 hasOpenAccess W2007403234 @default.
• W2007403234 hasPrimaryLocation W20074032341 @default.
• W2007403234 hasRelatedWork W2014862321 @default.
• W2007403234 hasRelatedWork W2084520738 @default.
• W2007403234 hasRelatedWork W2121734196 @default.
• W2007403234 hasRelatedWork W2187095366 @default.
• W2007403234 hasRelatedWork W2352393149 @default.
• W2007403234 hasRelatedWork W2411510431 @default.
• W2007403234 hasRelatedWork W2883289292 @default.
• W2007403234 hasRelatedWork W3002700213 @default.
• W2007403234 hasRelatedWork W4317888324 @default.
• W2007403234 hasRelatedWork W4383873209 @default.
• W2007403234 hasVolume "29" @default.
• W2007403234 isParatext "false" @default.
• W2007403234 isRetracted "false" @default.
• W2007403234 magId "2007403234" @default.
• W2007403234 workType "article" @default.