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• W2007403246 abstract "Abstract Enhanced green fluorescence protein (eGFP)‐labeled bone marrow (BM) cells were transplanted into syngeneic C57BL/6 (wild‐type) mice to investigate the distribution pattern, immunohistochemical characteristics, three‐dimensional structure, and ultrastructure of the BM‐derived cells in the mouse cornea using a fluorescence microscope, a confocal laser scanning microscope, and a transmission electron microscope. This study provided direct evidence that two morphologically distinct types of BM‐derived cells were distributed in the mouse cornea. The majority of the GFP(+) cells showed a flattened polygonal form with obtuse angles and these cells were distributed in the corneal stroma. The other type was the GFP(+) cells demonstrating slim cell bodies with long and extremely thin dendrites and which were distributed in the corneal epithelium. The immunohistochemical characteristics and ultrastructure of BM‐derived cells suggest that most of these cells have a macrophage lineage, whereas some cells in the corneal stroma do not. Interestingly, the direct intimate contact between GFP‐labeled BM derived cells and non‐GFP‐labeled resident cells within the corneal stroma were also clearly visualized at the fine structural level. These data provide new and more detailed insight into the nature of BM‐derived cells in the cornea. Anat Rec, 2009. © 2009 Wiley‐Liss, Inc." @default.
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• W2007403246 date "2009-02-18" @default.
• W2007403246 modified "2023-10-15" @default.
• W2007403246 title "Characteristic Morphology and Distribution of Bone Marrow Derived Cells in the Cornea" @default.
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• W2007403246 doi "https://doi.org/10.1002/ar.20851" @default.
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