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• W2007404448 abstract "GENETIC FACTORS and environmental influences determine immune defenses. Early immunologic reactions after transplantation may provide a clue to the further evolution of the transplanted organ. The major factors that determine the long-term results of kidney transplantation are rejection and infection. Early and adequate therapy favorably influences the subsequent course. Early identification of patients at risk for septic complications or rejection, therefore, is important. Interleukins are mediators of intercellular communication, triggering the immunologic responses of alloantigen recognition and defense, or tolerance. Although certain cytokines display stimulatory effects in vitro, others appear to attenuate T-cell responsiveness. In vivo the impact of these complementary and apparently competitive effects is still incompletely understood. Interleukins-6 (IL-6), a potent inducer of acute-phase proteins, has been shown to repress tumor necrosis factor (TNF) synthesis by monocytes. IL-6 is increased in peripheral blood during infection or transplant rejection. Interleukin-8 (IL-8), an acute-phase cytokine mediating infection and tumor defenses via neutrophil and T-cell chemoattraction; is also observed to be increased during transplant rejection, especially in tissues with irreversible rejection. Similarly, it is increased among patients with a fatal outcome after posttransplantation sepsis. Interleukin-10 (IL-10), a regulatory cytokine of inflammatory responses that is produced by peripheral blood mononuclear cells to induce T cell anergy and inhibit activated monocytes and macrophages, acts as a general inhibitor of proliferative and cytokine responses of both Th1 and Th2 type lymphocytes. It has been proposed as a mediator of transplant tolerance, but has been observed to be increased prior to rejection. Because acute rejection is the most common cause of transplant dysfunction, its early diagnosis and differentiation from other causes has been the goal of many investigations. It also may be assumed that evidence of an early immunologic reaction toward the stimulus “transplantation” might provide a clue concerning the later course. The aim of this study was to assess the prognostic value of IL-6, IL-8, and IL-10 levels in blood and urine as early markers of the evolution of recipient responses and transplant function after transplantation. PATIENTS AND METHODS" @default.
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• W2007404448 date "2003-06-01" @default.
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• W2007404448 title "Interleukin-6, interleukin-8, and interleukin-10 in kidney transplantation: improved risk strategy?" @default.
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• W2007404448 doi "https://doi.org/10.1016/s0041-1345(03)00529-3" @default.
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