Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007409108> ?p ?o ?g. }
- W2007409108 endingPage "1420" @default.
- W2007409108 startingPage "1411" @default.
- W2007409108 abstract "Excess dietary fat intake can induce lipotoxicity in non-adipose tissues. The aim of this study was to observe the effects of dietary high-fat lard intake on thyroid in rats. Male Sprague-Dawley rats were fed a high-fat lard diet for 24 weeks, and then the rats were fed a normal control diet (acute dietary modification) or the high-fat lard diet for another 6 weeks. The serum lipid profile, total thyroxine (TT4), free thyroxine (FT4) and thyrotropin (TSH) levels were determined at the 12, 18, 24 and 30 weeks. High-frequency ultrasound scanning of the thyroid glands was performed at the 24 or 30 weeks. After the rats were sacrificed, the thyroid glands were collected for histological and immunohistochemical analyses. The high-fat lard diet significantly increased triglyceride levels in both the serum and thyroid, and decreased serum TT4 and FT4 levels in parallel with elevated serum TSH levels. Ultrasonic imaging revealed enlarged thyroid glands with lowered echotexture and relatively heterogeneous features in the high-fat lard fed rats. The thyroid glands from the high-fat lard fed rats exhibited enlarged follicle cavities and flattened follicular epithelial cells under light microscopy, and dilated endoplasmic reticulum cisternae, twisted nuclei, fewer microvilli and secretory vesicles under transmission electron microscopy. Furthermore, the thyroid glands from the high-fat lard fed rats showed markedly low levels of thyroid hormone synthesis-related proteins TTF-1 and NIS. Acute dietary modification by withdrawal of the high-fat lard diet for 6 weeks failed to ameliorate the high-fat lard diet-induced thyroid changes. Dietary high-fat lard intake induces significant thyroid dysfunction and abnormal morphology in rats, which can not be corrected by short-term dietary modification." @default.
- W2007409108 created "2016-06-24" @default.
- W2007409108 creator A5020920264 @default.
- W2007409108 creator A5037887747 @default.
- W2007409108 creator A5040442512 @default.
- W2007409108 creator A5043874453 @default.
- W2007409108 creator A5044592466 @default.
- W2007409108 creator A5053001480 @default.
- W2007409108 creator A5059249723 @default.
- W2007409108 creator A5068100608 @default.
- W2007409108 creator A5081861642 @default.
- W2007409108 creator A5082665910 @default.
- W2007409108 creator A5083618838 @default.
- W2007409108 date "2014-09-29" @default.
- W2007409108 modified "2023-10-06" @default.
- W2007409108 title "Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats" @default.
- W2007409108 cites W1493370386 @default.
- W2007409108 cites W1815693763 @default.
- W2007409108 cites W1963556467 @default.
- W2007409108 cites W1966691211 @default.
- W2007409108 cites W1975329694 @default.
- W2007409108 cites W1983517331 @default.
- W2007409108 cites W1983644247 @default.
- W2007409108 cites W1988973837 @default.
- W2007409108 cites W2002181851 @default.
- W2007409108 cites W2008080358 @default.
- W2007409108 cites W2010914260 @default.
- W2007409108 cites W2024169992 @default.
- W2007409108 cites W2026316114 @default.
- W2007409108 cites W2034254085 @default.
- W2007409108 cites W2039311873 @default.
- W2007409108 cites W2042441156 @default.
- W2007409108 cites W2051793369 @default.
- W2007409108 cites W2057038024 @default.
- W2007409108 cites W2061038893 @default.
- W2007409108 cites W2061176979 @default.
- W2007409108 cites W2061564753 @default.
- W2007409108 cites W2067042708 @default.
- W2007409108 cites W2069243406 @default.
- W2007409108 cites W2071918247 @default.
- W2007409108 cites W2081731224 @default.
- W2007409108 cites W2086944630 @default.
- W2007409108 cites W2090335621 @default.
- W2007409108 cites W2095287442 @default.
- W2007409108 cites W2095483941 @default.
- W2007409108 cites W2097787450 @default.
- W2007409108 cites W2103413312 @default.
- W2007409108 cites W2121309304 @default.
- W2007409108 cites W2136436053 @default.
- W2007409108 cites W2136828698 @default.
- W2007409108 cites W2137662702 @default.
- W2007409108 cites W2138994122 @default.
- W2007409108 cites W2142596760 @default.
- W2007409108 cites W2144214075 @default.
- W2007409108 cites W2147923689 @default.
- W2007409108 cites W2159450041 @default.
- W2007409108 cites W2162864148 @default.
- W2007409108 cites W2165103770 @default.
- W2007409108 cites W2166788192 @default.
- W2007409108 cites W2467824185 @default.
- W2007409108 cites W2559680414 @default.
- W2007409108 cites W4243801719 @default.
- W2007409108 doi "https://doi.org/10.1038/aps.2014.82" @default.
- W2007409108 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4220075" @default.
- W2007409108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25263336" @default.
- W2007409108 hasPublicationYear "2014" @default.
- W2007409108 type Work @default.
- W2007409108 sameAs 2007409108 @default.
- W2007409108 citedByCount "45" @default.
- W2007409108 countsByYear W20074091082015 @default.
- W2007409108 countsByYear W20074091082016 @default.
- W2007409108 countsByYear W20074091082017 @default.
- W2007409108 countsByYear W20074091082018 @default.
- W2007409108 countsByYear W20074091082019 @default.
- W2007409108 countsByYear W20074091082020 @default.
- W2007409108 countsByYear W20074091082021 @default.
- W2007409108 countsByYear W20074091082022 @default.
- W2007409108 countsByYear W20074091082023 @default.
- W2007409108 crossrefType "journal-article" @default.
- W2007409108 hasAuthorship W2007409108A5020920264 @default.
- W2007409108 hasAuthorship W2007409108A5037887747 @default.
- W2007409108 hasAuthorship W2007409108A5040442512 @default.
- W2007409108 hasAuthorship W2007409108A5043874453 @default.
- W2007409108 hasAuthorship W2007409108A5044592466 @default.
- W2007409108 hasAuthorship W2007409108A5053001480 @default.
- W2007409108 hasAuthorship W2007409108A5059249723 @default.
- W2007409108 hasAuthorship W2007409108A5068100608 @default.
- W2007409108 hasAuthorship W2007409108A5081861642 @default.
- W2007409108 hasAuthorship W2007409108A5082665910 @default.
- W2007409108 hasAuthorship W2007409108A5083618838 @default.
- W2007409108 hasBestOaLocation W20074091081 @default.
- W2007409108 hasConcept C126322002 @default.
- W2007409108 hasConcept C134018914 @default.
- W2007409108 hasConcept C171089720 @default.
- W2007409108 hasConcept C185592680 @default.
- W2007409108 hasConcept C2778163477 @default.
- W2007409108 hasConcept C2778913445 @default.
- W2007409108 hasConcept C526584372 @default.