Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007409478> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2007409478 abstract "Voltage-gated K+ (Kv) channels play a crucial role in the generation of cellular action potentials. Kv channels open and close in response to changes in transmembrane voltage. A further regulatory mechanism is channel inactivation, which occurs at the K+ selectivity filter and is of particular importance in the cardiac K+ channel hERG, that plays a major role in controlling the human heart rate. In a series of molecular dynamics simulations, we identified an extensive hydrogen bond network around residues S620 and N629 that controls the conformation of the selectivity filter and should therefore have a great impact on inactivation. We show that the distance of N629 to S620 acts as a nearly linear switch to drive the K+ selectivity filter from its conductive to a collapsed state similar to the low K+ conformation of KcsA. Electrophysiological measurements on mutants with altered H-bonding networks display either reduced or even fully abolished inactivation and thus support our hypothesis. Additionally, our simulations revealed a sidepocket extending from the central cavity, only present in the conductive state. These pockets are sufficently large to accommodate molecules of the newly found class of hERG-activators and reveal a first hint at their putative molecular mechanism." @default.
- W2007409478 created "2016-06-24" @default.
- W2007409478 creator A5002086598 @default.
- W2007409478 creator A5042972081 @default.
- W2007409478 creator A5044839728 @default.
- W2007409478 creator A5066306154 @default.
- W2007409478 creator A5071615457 @default.
- W2007409478 creator A5075419050 @default.
- W2007409478 creator A5083400955 @default.
- W2007409478 date "2012-01-01" @default.
- W2007409478 modified "2023-09-28" @default.
- W2007409478 title "Molecular Determinants in K+ Channel hERG Inactivation Gating" @default.
- W2007409478 doi "https://doi.org/10.1016/j.bpj.2011.11.2894" @default.
- W2007409478 hasPublicationYear "2012" @default.
- W2007409478 type Work @default.
- W2007409478 sameAs 2007409478 @default.
- W2007409478 citedByCount "1" @default.
- W2007409478 countsByYear W20074094782012 @default.
- W2007409478 crossrefType "journal-article" @default.
- W2007409478 hasAuthorship W2007409478A5002086598 @default.
- W2007409478 hasAuthorship W2007409478A5042972081 @default.
- W2007409478 hasAuthorship W2007409478A5044839728 @default.
- W2007409478 hasAuthorship W2007409478A5066306154 @default.
- W2007409478 hasAuthorship W2007409478A5071615457 @default.
- W2007409478 hasAuthorship W2007409478A5075419050 @default.
- W2007409478 hasAuthorship W2007409478A5083400955 @default.
- W2007409478 hasBestOaLocation W20074094781 @default.
- W2007409478 hasConcept C118792377 @default.
- W2007409478 hasConcept C12554922 @default.
- W2007409478 hasConcept C146403970 @default.
- W2007409478 hasConcept C147597530 @default.
- W2007409478 hasConcept C161790260 @default.
- W2007409478 hasConcept C169760540 @default.
- W2007409478 hasConcept C170493617 @default.
- W2007409478 hasConcept C185263204 @default.
- W2007409478 hasConcept C185592680 @default.
- W2007409478 hasConcept C18903297 @default.
- W2007409478 hasConcept C194544171 @default.
- W2007409478 hasConcept C2778530040 @default.
- W2007409478 hasConcept C2779362680 @default.
- W2007409478 hasConcept C2779965526 @default.
- W2007409478 hasConcept C45516822 @default.
- W2007409478 hasConcept C50254741 @default.
- W2007409478 hasConcept C55493867 @default.
- W2007409478 hasConcept C59593255 @default.
- W2007409478 hasConcept C71240020 @default.
- W2007409478 hasConcept C79743260 @default.
- W2007409478 hasConcept C83743174 @default.
- W2007409478 hasConcept C86803240 @default.
- W2007409478 hasConceptScore W2007409478C118792377 @default.
- W2007409478 hasConceptScore W2007409478C12554922 @default.
- W2007409478 hasConceptScore W2007409478C146403970 @default.
- W2007409478 hasConceptScore W2007409478C147597530 @default.
- W2007409478 hasConceptScore W2007409478C161790260 @default.
- W2007409478 hasConceptScore W2007409478C169760540 @default.
- W2007409478 hasConceptScore W2007409478C170493617 @default.
- W2007409478 hasConceptScore W2007409478C185263204 @default.
- W2007409478 hasConceptScore W2007409478C185592680 @default.
- W2007409478 hasConceptScore W2007409478C18903297 @default.
- W2007409478 hasConceptScore W2007409478C194544171 @default.
- W2007409478 hasConceptScore W2007409478C2778530040 @default.
- W2007409478 hasConceptScore W2007409478C2779362680 @default.
- W2007409478 hasConceptScore W2007409478C2779965526 @default.
- W2007409478 hasConceptScore W2007409478C45516822 @default.
- W2007409478 hasConceptScore W2007409478C50254741 @default.
- W2007409478 hasConceptScore W2007409478C55493867 @default.
- W2007409478 hasConceptScore W2007409478C59593255 @default.
- W2007409478 hasConceptScore W2007409478C71240020 @default.
- W2007409478 hasConceptScore W2007409478C79743260 @default.
- W2007409478 hasConceptScore W2007409478C83743174 @default.
- W2007409478 hasConceptScore W2007409478C86803240 @default.
- W2007409478 hasLocation W20074094781 @default.
- W2007409478 hasOpenAccess W2007409478 @default.
- W2007409478 hasPrimaryLocation W20074094781 @default.
- W2007409478 hasRelatedWork W1968695132 @default.
- W2007409478 hasRelatedWork W1979364692 @default.
- W2007409478 hasRelatedWork W1983163979 @default.
- W2007409478 hasRelatedWork W1998049733 @default.
- W2007409478 hasRelatedWork W2016430838 @default.
- W2007409478 hasRelatedWork W2023031952 @default.
- W2007409478 hasRelatedWork W2043013208 @default.
- W2007409478 hasRelatedWork W2045192609 @default.
- W2007409478 hasRelatedWork W2060685788 @default.
- W2007409478 hasRelatedWork W2081465809 @default.
- W2007409478 hasRelatedWork W2093723171 @default.
- W2007409478 hasRelatedWork W2110864963 @default.
- W2007409478 hasRelatedWork W2110898667 @default.
- W2007409478 hasRelatedWork W2152195928 @default.
- W2007409478 hasRelatedWork W2155757617 @default.
- W2007409478 hasRelatedWork W2802475651 @default.
- W2007409478 hasRelatedWork W2948479071 @default.
- W2007409478 hasRelatedWork W3188874224 @default.
- W2007409478 hasRelatedWork W3201367039 @default.
- W2007409478 hasRelatedWork W415956984 @default.
- W2007409478 isParatext "false" @default.
- W2007409478 isRetracted "false" @default.
- W2007409478 magId "2007409478" @default.
- W2007409478 workType "article" @default.