Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007416099> ?p ?o ?g. }
- W2007416099 endingPage "52" @default.
- W2007416099 startingPage "45" @default.
- W2007416099 abstract "Cells maintain precise gene expression by balancing transcriptional activation and repression. While much work has focused on elucidating transcriptional activation in the central nervous system (CNS), little is known about transcriptional repression. One means to repress gene expression is to initiate binding of transcription factors to DNA, which then recruit co-repressors as well as other accessory proteins, forming a multi-protein repressor complex. These multi-protein repressor complexes include histone modifying enzymes that trigger processes such as histone acetylation, methylation, and ubiquitylation, altering chromatin structures to impact gene expression. Within these complexes transcriptional repressor proteins per se do not exhibit enzymatic reactions to remodel chromatin structure, whereas histone modifying enzymes lack intrinsic DNA binding activity but have an ability to process post-translational modifications on histones. Thus, the mutual association between transcriptional repressors and histone modifying enzymes is essential to sculpt chromatin to favor transcriptional repression and down regulate gene expression. Additionally, co-repressors are integral components in the context of gene repression as they bridge the association of transcriptional repressors and histone modifying enzymes. In this review, we will discuss the roles of some of the major components of these repressor complex in the CNS as well as their cellular functions that may underlie fundamental behavior in animals. This article is part of the Special Issue entitled ‘Neuroepigenetic Disorders’." @default.
- W2007416099 created "2016-06-24" @default.
- W2007416099 creator A5031819667 @default.
- W2007416099 creator A5055334509 @default.
- W2007416099 date "2014-05-01" @default.
- W2007416099 modified "2023-09-25" @default.
- W2007416099 title "Decoding transcriptional repressor complexes in the adult central nervous system" @default.
- W2007416099 cites W1486257535 @default.
- W2007416099 cites W1488115555 @default.
- W2007416099 cites W1516514579 @default.
- W2007416099 cites W1525573602 @default.
- W2007416099 cites W1559742681 @default.
- W2007416099 cites W1628658472 @default.
- W2007416099 cites W1784857457 @default.
- W2007416099 cites W1910848366 @default.
- W2007416099 cites W1963542234 @default.
- W2007416099 cites W1964159332 @default.
- W2007416099 cites W1964233786 @default.
- W2007416099 cites W1964951942 @default.
- W2007416099 cites W1969021739 @default.
- W2007416099 cites W1970693538 @default.
- W2007416099 cites W1973672022 @default.
- W2007416099 cites W1974814280 @default.
- W2007416099 cites W1974950833 @default.
- W2007416099 cites W1975791071 @default.
- W2007416099 cites W1976507388 @default.
- W2007416099 cites W1976980117 @default.
- W2007416099 cites W1977690815 @default.
- W2007416099 cites W1987397557 @default.
- W2007416099 cites W1991979408 @default.
- W2007416099 cites W1992789817 @default.
- W2007416099 cites W1993341628 @default.
- W2007416099 cites W1993415518 @default.
- W2007416099 cites W1993947112 @default.
- W2007416099 cites W2000490360 @default.
- W2007416099 cites W2001621733 @default.
- W2007416099 cites W2001936578 @default.
- W2007416099 cites W2002676132 @default.
- W2007416099 cites W2005414132 @default.
- W2007416099 cites W2005619892 @default.
- W2007416099 cites W2007034511 @default.
- W2007416099 cites W2007468095 @default.
- W2007416099 cites W2011263116 @default.
- W2007416099 cites W2012833215 @default.
- W2007416099 cites W2012911133 @default.
- W2007416099 cites W2021409596 @default.
- W2007416099 cites W2033609439 @default.
- W2007416099 cites W2035090622 @default.
- W2007416099 cites W2036475318 @default.
- W2007416099 cites W2039276157 @default.
- W2007416099 cites W2042966900 @default.
- W2007416099 cites W2045023687 @default.
- W2007416099 cites W2050189729 @default.
- W2007416099 cites W2054835199 @default.
- W2007416099 cites W2054848045 @default.
- W2007416099 cites W2067004457 @default.
- W2007416099 cites W2067523496 @default.
- W2007416099 cites W2069783754 @default.
- W2007416099 cites W2071962829 @default.
- W2007416099 cites W2081756408 @default.
- W2007416099 cites W2083744767 @default.
- W2007416099 cites W2090611194 @default.
- W2007416099 cites W2090760765 @default.
- W2007416099 cites W2091508315 @default.
- W2007416099 cites W2091791524 @default.
- W2007416099 cites W2091811407 @default.
- W2007416099 cites W2093596395 @default.
- W2007416099 cites W2098680943 @default.
- W2007416099 cites W2104261628 @default.
- W2007416099 cites W2108017291 @default.
- W2007416099 cites W2108470366 @default.
- W2007416099 cites W2109008714 @default.
- W2007416099 cites W2118504835 @default.
- W2007416099 cites W2119137351 @default.
- W2007416099 cites W2121053876 @default.
- W2007416099 cites W2122522583 @default.
- W2007416099 cites W2127311839 @default.
- W2007416099 cites W2129032286 @default.
- W2007416099 cites W2131090755 @default.
- W2007416099 cites W2134771103 @default.
- W2007416099 cites W2136879986 @default.
- W2007416099 cites W2137719949 @default.
- W2007416099 cites W2140273266 @default.
- W2007416099 cites W2140523553 @default.
- W2007416099 cites W2142388403 @default.
- W2007416099 cites W2146070554 @default.
- W2007416099 cites W2154087863 @default.
- W2007416099 cites W2155388782 @default.
- W2007416099 cites W2159726740 @default.
- W2007416099 cites W2160655220 @default.
- W2007416099 cites W2163154029 @default.
- W2007416099 cites W2164675798 @default.
- W2007416099 cites W2165613640 @default.
- W2007416099 cites W2168448928 @default.
- W2007416099 doi "https://doi.org/10.1016/j.neuropharm.2013.12.024" @default.
- W2007416099 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3984594" @default.
- W2007416099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24418103" @default.
- W2007416099 hasPublicationYear "2014" @default.