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• W2007423639 endingPage "91" @default.
• W2007423639 startingPage "79" @default.
• W2007423639 abstract "Here, we present a study of polar residues within the membrane core of alpha-helical membrane proteins. As expected, polar residues are less frequent in the membrane than expected. Further, most of these residues are buried within the interior of the protein and are only rarely exposed to lipids. However, the polar groups often border internal water filled cavities, even if the rest of the sidechain is buried. A survey of their functional roles in known structures showed that the polar residues are often directly involved in binding of small compounds, especially in channels and transporters, but other functions including proton transfer, catalysis, and selectivity have also been attributed to these proteins. Among the polar residues histidines often interact with prosthetic groups in photosynthetic- and oxidoreductase-related proteins, whereas prolines often are required for conformational changes of the proteins. Indeed, the polar residues in the membrane core are more conserved than other residues in the core, as well as more conserved than polar residues outside the membrane. The reason is twofold; they are often (i) buried in the interior of the protein and (ii) directly involved in the function of the proteins. Finally, a method to identify which polar residues are present within the membrane core directly from protein sequences was developed. Applying the method to the set of all human membrane proteins the prediction indicates that polar residues were most frequent among active transporter proteins and GPCRs, whereas infrequent in families with few transmembrane regions, such as non-GPCR receptors." @default.
• W2007423639 created "2016-06-24" @default.
• W2007423639 creator A5032011846 @default.
• W2007423639 creator A5041124853 @default.
• W2007423639 creator A5072903725 @default.
• W2007423639 date "2010-10-11" @default.
• W2007423639 modified "2023-10-09" @default.
• W2007423639 title "Why are polar residues within the membrane core evolutionary conserved?" @default.
• W2007423639 cites W1524847237 @default.
• W2007423639 cites W1537016059 @default.
• W2007423639 cites W1912107272 @default.
• W2007423639 cites W1966112781 @default.
• W2007423639 cites W1967513793 @default.
• W2007423639 cites W1969129798 @default.
• W2007423639 cites W1977896619 @default.
• W2007423639 cites W1978908092 @default.
• W2007423639 cites W1985400607 @default.
• W2007423639 cites W1988097700 @default.
• W2007423639 cites W1988601980 @default.
• W2007423639 cites W1996478334 @default.
• W2007423639 cites W2000729091 @default.
• W2007423639 cites W2001183280 @default.
• W2007423639 cites W2001641653 @default.
• W2007423639 cites W2003037477 @default.
• W2007423639 cites W2005501525 @default.
• W2007423639 cites W2007176314 @default.
• W2007423639 cites W2009118272 @default.
• W2007423639 cites W2013643486 @default.
• W2007423639 cites W2013711061 @default.
• W2007423639 cites W2015341379 @default.
• W2007423639 cites W2023414513 @default.
• W2007423639 cites W2028310816 @default.
• W2007423639 cites W2031215741 @default.
• W2007423639 cites W2035506170 @default.
• W2007423639 cites W2038708776 @default.
• W2007423639 cites W2044272839 @default.
• W2007423639 cites W2045078334 @default.
• W2007423639 cites W2046267877 @default.
• W2007423639 cites W2053116433 @default.
• W2007423639 cites W2056770911 @default.
• W2007423639 cites W2057702599 @default.
• W2007423639 cites W2059382484 @default.
• W2007423639 cites W2062355909 @default.
• W2007423639 cites W2062663912 @default.
• W2007423639 cites W2063623087 @default.
• W2007423639 cites W2068770352 @default.
• W2007423639 cites W2068816427 @default.
• W2007423639 cites W2071282889 @default.
• W2007423639 cites W2072470496 @default.
• W2007423639 cites W2073726493 @default.
• W2007423639 cites W2076048958 @default.
• W2007423639 cites W2079820221 @default.
• W2007423639 cites W2083907491 @default.
• W2007423639 cites W2087094813 @default.
• W2007423639 cites W2087938597 @default.
• W2007423639 cites W2091913497 @default.
• W2007423639 cites W2097775366 @default.
• W2007423639 cites W2099384461 @default.
• W2007423639 cites W2104477830 @default.
• W2007423639 cites W2104622728 @default.
• W2007423639 cites W2105370173 @default.
• W2007423639 cites W2105546584 @default.
• W2007423639 cites W2106612397 @default.
• W2007423639 cites W2107460409 @default.
• W2007423639 cites W2110434926 @default.
• W2007423639 cites W2114090589 @default.
• W2007423639 cites W2115357061 @default.
• W2007423639 cites W2116099439 @default.
• W2007423639 cites W2116565080 @default.
• W2007423639 cites W2123325966 @default.
• W2007423639 cites W2125851804 @default.
• W2007423639 cites W2128037544 @default.
• W2007423639 cites W2131553403 @default.
• W2007423639 cites W2131624523 @default.
• W2007423639 cites W2136364519 @default.
• W2007423639 cites W2137670821 @default.
• W2007423639 cites W2140230121 @default.
• W2007423639 cites W2140237162 @default.
• W2007423639 cites W2143015200 @default.
• W2007423639 cites W2144944670 @default.
• W2007423639 cites W2145336405 @default.
• W2007423639 cites W2147241123 @default.
• W2007423639 cites W2150264392 @default.
• W2007423639 cites W2151055502 @default.
• W2007423639 cites W2151156268 @default.
• W2007423639 cites W2151871964 @default.
• W2007423639 cites W2151994158 @default.
• W2007423639 cites W2153331570 @default.
• W2007423639 cites W2153635784 @default.
• W2007423639 cites W2155147384 @default.
• W2007423639 cites W2156125289 @default.
• W2007423639 cites W2156212384 @default.
• W2007423639 cites W2157380138 @default.
• W2007423639 cites W2158613515 @default.
• W2007423639 cites W2158714788 @default.
• W2007423639 cites W2170907233 @default.
• W2007423639 doi "https://doi.org/10.1002/prot.22859" @default.
• W2007423639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20938980" @default.

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