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• W2007426346 abstract "Cyclin-dependent kinase inhibitor (CDKN1A), often referred to as p21(Waf1/Cip1) (p21), is induced by a variety of environmental stresses. Transcription factor ELK-1 is a member of the ETS oncogene superfamily. Here, we show that ELK-1 directly trans-activates the p21 gene, independently of p53 and EGR-1, in sodium arsenite (NaASO(2))-exposed HaCaT cells. Promoter deletion analysis and site-directed mutagenesis identified the presence of an ELK-1-binding core motif between -190 and -170 bp of the p21 promoter that confers inducibility by NaASO(2). Chromatin immunoprecipitation and electrophoretic mobility shift analyses confirmed the specific binding of ELK-1 to its putative binding sequence within the p21 promoter. In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA. The importance of ELK-1 in response to NaASO(2) was further confirmed by the observation that stable expression of ELK-1 siRNA in HaCaT cells resulted in the attenuation of NaASO(2)-induced p21 expression. Although ELK-1 was activated by ERK, JNK, and p38 MAPK in response to NaASO(2), ELK-1-mediated activation of the p21 promoter was largely dependent on ERK. In addition, EGR-1 induced by ELK-1 seemed to be involved in NaASO(2)-induced expression of BAX. This supports the view that the ERK/ELK-1 cascade is involved in p53-independent induction of p21 and BAX gene expression." @default.
• W2007426346 created "2016-06-24" @default.
• W2007426346 creator A5002034433 @default.
• W2007426346 creator A5004661611 @default.
• W2007426346 creator A5045747630 @default.
• W2007426346 creator A5057530985 @default.
• W2007426346 date "2011-07-01" @default.
• W2007426346 modified "2023-09-26" @default.
• W2007426346 title "The ETS Family Transcription Factor ELK-1 Regulates Induction of the Cell Cycle-regulatory Gene p21 and the BAX Gene in Sodium Arsenite-exposed Human Keratinocyte HaCaT Cells" @default.
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• W2007426346 doi "https://doi.org/10.1074/jbc.m110.216721" @default.
• W2007426346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3143646" @default.
• W2007426346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21642427" @default.
• W2007426346 hasPublicationYear "2011" @default.
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