Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007430235> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2007430235 endingPage "648" @default.
- W2007430235 startingPage "644" @default.
- W2007430235 abstract "Mast cells are implicated in stress-induced inflammatory skin diseases such as psoriasis. Mechanisms of stress-induced mast cell degranulation however, are not entirely clear. Here we explore the role of activation of a Substance P (SP) receptor (NK-1) on mast cell degranulation upon exposure to stress in rats. A specific nonpeptide NK-1 antagonist, CP99994 was used to treat the rats either peripherally or intracerebroventricularly. Because increased SP activity in the brain may mediate the stress response, we also examined cutaneous mast cell degranulation after central injection of SP. Stress, as well as SP injected centrally, increased mast cell degranulation. Both central and peripheral injection of CP99994 prevented stress-induced mast cell degranulation. Surprisingly, the combination of stress with SP decreased mast cell degranulation, suggesting that high levels of SP may counteract the stress responses. Results in this animal model suggest that NK-1 antagonists may be used therapeutically to treat stress-induced inflammatory skin diseases; however, drug doses should be chosen carefully." @default.
- W2007430235 created "2016-06-24" @default.
- W2007430235 creator A5021751539 @default.
- W2007430235 creator A5024946247 @default.
- W2007430235 creator A5027059519 @default.
- W2007430235 creator A5044181300 @default.
- W2007430235 creator A5048580605 @default.
- W2007430235 date "2004-11-01" @default.
- W2007430235 modified "2023-10-18" @default.
- W2007430235 title "NK-1 antagonist CP99994 inhibits stress-induced mast cell degranulation in rats" @default.
- W2007430235 cites W1493365371 @default.
- W2007430235 cites W1949759409 @default.
- W2007430235 cites W1969171962 @default.
- W2007430235 cites W1971277989 @default.
- W2007430235 cites W1988040613 @default.
- W2007430235 cites W1996315631 @default.
- W2007430235 cites W1996891599 @default.
- W2007430235 cites W1998950078 @default.
- W2007430235 cites W2001430892 @default.
- W2007430235 cites W2003072029 @default.
- W2007430235 cites W2011740298 @default.
- W2007430235 cites W2018210414 @default.
- W2007430235 cites W2021007793 @default.
- W2007430235 cites W2037348299 @default.
- W2007430235 cites W2067903473 @default.
- W2007430235 cites W2082847226 @default.
- W2007430235 cites W2111058306 @default.
- W2007430235 cites W2127828417 @default.
- W2007430235 cites W2156828370 @default.
- W2007430235 cites W2418513332 @default.
- W2007430235 cites W26279452 @default.
- W2007430235 cites W4233962645 @default.
- W2007430235 cites W4237942806 @default.
- W2007430235 doi "https://doi.org/10.1111/j.1365-2230.2004.01613.x" @default.
- W2007430235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15550145" @default.
- W2007430235 hasPublicationYear "2004" @default.
- W2007430235 type Work @default.
- W2007430235 sameAs 2007430235 @default.
- W2007430235 citedByCount "26" @default.
- W2007430235 countsByYear W20074302352012 @default.
- W2007430235 countsByYear W20074302352013 @default.
- W2007430235 countsByYear W20074302352014 @default.
- W2007430235 countsByYear W20074302352015 @default.
- W2007430235 countsByYear W20074302352016 @default.
- W2007430235 countsByYear W20074302352017 @default.
- W2007430235 countsByYear W20074302352021 @default.
- W2007430235 crossrefType "journal-article" @default.
- W2007430235 hasAuthorship W2007430235A5021751539 @default.
- W2007430235 hasAuthorship W2007430235A5024946247 @default.
- W2007430235 hasAuthorship W2007430235A5027059519 @default.
- W2007430235 hasAuthorship W2007430235A5044181300 @default.
- W2007430235 hasAuthorship W2007430235A5048580605 @default.
- W2007430235 hasConcept C126322002 @default.
- W2007430235 hasConcept C170493617 @default.
- W2007430235 hasConcept C185592680 @default.
- W2007430235 hasConcept C203014093 @default.
- W2007430235 hasConcept C2776885963 @default.
- W2007430235 hasConcept C2778122271 @default.
- W2007430235 hasConcept C2779726688 @default.
- W2007430235 hasConcept C49802076 @default.
- W2007430235 hasConcept C71924100 @default.
- W2007430235 hasConcept C98274493 @default.
- W2007430235 hasConceptScore W2007430235C126322002 @default.
- W2007430235 hasConceptScore W2007430235C170493617 @default.
- W2007430235 hasConceptScore W2007430235C185592680 @default.
- W2007430235 hasConceptScore W2007430235C203014093 @default.
- W2007430235 hasConceptScore W2007430235C2776885963 @default.
- W2007430235 hasConceptScore W2007430235C2778122271 @default.
- W2007430235 hasConceptScore W2007430235C2779726688 @default.
- W2007430235 hasConceptScore W2007430235C49802076 @default.
- W2007430235 hasConceptScore W2007430235C71924100 @default.
- W2007430235 hasConceptScore W2007430235C98274493 @default.
- W2007430235 hasIssue "6" @default.
- W2007430235 hasLocation W20074302351 @default.
- W2007430235 hasLocation W20074302352 @default.
- W2007430235 hasOpenAccess W2007430235 @default.
- W2007430235 hasPrimaryLocation W20074302351 @default.
- W2007430235 hasRelatedWork W1456597060 @default.
- W2007430235 hasRelatedWork W1991211715 @default.
- W2007430235 hasRelatedWork W1998397846 @default.
- W2007430235 hasRelatedWork W2045958004 @default.
- W2007430235 hasRelatedWork W2049458831 @default.
- W2007430235 hasRelatedWork W2061469309 @default.
- W2007430235 hasRelatedWork W2071148444 @default.
- W2007430235 hasRelatedWork W2077706878 @default.
- W2007430235 hasRelatedWork W2512190522 @default.
- W2007430235 hasRelatedWork W2921953980 @default.
- W2007430235 hasVolume "29" @default.
- W2007430235 isParatext "false" @default.
- W2007430235 isRetracted "false" @default.
- W2007430235 magId "2007430235" @default.
- W2007430235 workType "article" @default.