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- W2007435619 abstract "A very large number of compounds is now known which reproduce or imitate the action of the naturally occurring oestrogens. The outstanding researches of Dodds and his co-workers have shown that, while potencies equalling or approaching those of the natural substances seem to be possessed only by those synthetic compounds which appear to be closely related to them in structural configuration, the structure of other more weakly oestrogenic compounds may diverge considerably from this type. Stroud [1940] has shown, however, that when diphenyl, diphenyl ether, diphenylmethane, stilbene and γ:δ-diphenyl-β:δ-hexadiene are injected into female rabbits, phenolic metabolic products are excreted, which are usually more active oestrogenically than the parent compounds. It might be supposed, therefore, that the activity shown by the non-phenolic precursors is due to the formation of the phenols in vivo. The question thus arises, which of the apparently active substances so far described are direct oestrogens, and" @default.
- W2007435619 created "2016-06-24" @default.
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- W2007435619 date "1940-01-01" @default.
- W2007435619 modified "2023-10-05" @default.
- W2007435619 title "PRECURSORS OF OESTROGENS" @default.
- W2007435619 doi "https://doi.org/10.1677/joe.0.0020444" @default.
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