FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007440230> ?p ?o ?g. }

• W2007440230 abstract "Antimicrobial resistance of Neisseria gonorrhoeae is a serious health problem in China. Gonococcal antimicrobial susceptibility has been monitored in Shanghai since 1988. In this study, we examined the changing pattern of gonococcal antimicrobial susceptibility based on data from N. gonorrhoeae isolates collected over the past 25 years. Approximately 100–200 isolates each year (1988–2013) were tested for their susceptibility to penicillin (PEN), tetracycline (TET), ciprofloxacin (CIP), ceftriaxone (CRO) and spectinomycin (SPT), using the agar dilution method. Plasmid-mediated N. gonorrhoeae antimicrobial resistance, comprising penicillinase-producing N. gonorrhoeae (presumed PPNG) and high-level tetracycline resistance N. gonorrhoeae (presumed TRNG), were also determined. Breakpoints for susceptibilities followed those described by the Clinical and Laboratory Standard Institute and the European Committee on Antimicrobial Susceptibility Testing. A high proportion of isolates were resistant to PEN, TET and CIP, ranging from less than 20% at the beginning of the survey, increasing in the late 1990s and reaching over 90% in recent years. The proportion of isolates exhibiting plasmid-mediated resistance exceeded 38% for presumed PPNG and 20% for presumed TRNG in recent years. The proportion of CRO nonsusceptible isolates (MIC ≥ 0.125 mg/L) ranged from 7% to 13% in most of the study years. Almost all isolates were susceptible to SPT. The SPT MIC90 was 16–32 mg/L for 2008–2013. The proportion of CRO nonsusceptible-associated multiple-drug-resistant (MDR) isolates was over 5% in most of the study years. N. gonorrhoeae isolates in Shanghai were resistant to PEN, TET and CIP. Furthermore, CRO nonsusceptible and MDR isolates were prevalent. N. gonorrhoeae isolates were also found to be susceptible to SPT. It is recommended that the CRO dose be increased from currently recommended 250 mg to 500 mg and that SPT be an alternative in treating urogenital gonorrhea. Our findings highlight the importance of both regional and national surveillance programs for the prompt modification of treatment guidelines, vital in responding to the changing pattern of gonococcal antimicrobial susceptibility." @default.
• W2007440230 created "2016-06-24" @default.
• W2007440230 creator A5013362776 @default.
• W2007440230 creator A5044116927 @default.
• W2007440230 creator A5044904833 @default.
• W2007440230 creator A5049692788 @default.
• W2007440230 creator A5062964120 @default.
• W2007440230 creator A5062996178 @default.
• W2007440230 date "2014-12-01" @default.
• W2007440230 modified "2023-10-06" @default.
• W2007440230 title "Twenty-five-year changing pattern of gonococcal antimicrobial susceptibility in Shanghai: surveillance and its impact on treatment guidelines" @default.
• W2007440230 cites W1967593111 @default.
• W2007440230 cites W1984727125 @default.
• W2007440230 cites W1987523762 @default.
• W2007440230 cites W1987952286 @default.
• W2007440230 cites W1988877992 @default.
• W2007440230 cites W2002358534 @default.
• W2007440230 cites W2010906969 @default.
• W2007440230 cites W2014682970 @default.
• W2007440230 cites W2022572193 @default.
• W2007440230 cites W2056939438 @default.
• W2007440230 cites W2058828207 @default.
• W2007440230 cites W2059422324 @default.
• W2007440230 cites W2066364915 @default.
• W2007440230 cites W2085077588 @default.
• W2007440230 cites W2093338633 @default.
• W2007440230 cites W2102057212 @default.
• W2007440230 cites W2111450162 @default.
• W2007440230 cites W2112922778 @default.
• W2007440230 cites W2147292570 @default.
• W2007440230 cites W2149433111 @default.
• W2007440230 cites W2155599871 @default.
• W2007440230 cites W2164323125 @default.
• W2007440230 cites W2167657860 @default.
• W2007440230 cites W2171521043 @default.
• W2007440230 cites W2321147270 @default.
• W2007440230 cites W2404021176 @default.
• W2007440230 cites W3139984863 @default.
• W2007440230 cites W4232311460 @default.
• W2007440230 doi "https://doi.org/10.1186/s12879-014-0731-9" @default.
• W2007440230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4334756" @default.
• W2007440230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25547132" @default.
• W2007440230 hasPublicationYear "2014" @default.
• W2007440230 type Work @default.
• W2007440230 sameAs 2007440230 @default.
• W2007440230 citedByCount "13" @default.
• W2007440230 countsByYear W20074402302016 @default.
• W2007440230 countsByYear W20074402302017 @default.
• W2007440230 countsByYear W20074402302018 @default.
• W2007440230 countsByYear W20074402302019 @default.
• W2007440230 countsByYear W20074402302020 @default.
• W2007440230 crossrefType "journal-article" @default.
• W2007440230 hasAuthorship W2007440230A5013362776 @default.
• W2007440230 hasAuthorship W2007440230A5044116927 @default.
• W2007440230 hasAuthorship W2007440230A5044904833 @default.
• W2007440230 hasAuthorship W2007440230A5049692788 @default.
• W2007440230 hasAuthorship W2007440230A5062964120 @default.
• W2007440230 hasAuthorship W2007440230A5062996178 @default.
• W2007440230 hasBestOaLocation W20074402301 @default.
• W2007440230 hasConcept C114851261 @default.
• W2007440230 hasConcept C174802600 @default.
• W2007440230 hasConcept C176947019 @default.
• W2007440230 hasConcept C190139176 @default.
• W2007440230 hasConcept C2776520383 @default.
• W2007440230 hasConcept C2778063948 @default.
• W2007440230 hasConcept C2778243283 @default.
• W2007440230 hasConcept C2778512257 @default.
• W2007440230 hasConcept C2779166590 @default.
• W2007440230 hasConcept C2780493024 @default.
• W2007440230 hasConcept C2780923616 @default.
• W2007440230 hasConcept C4937899 @default.
• W2007440230 hasConcept C501593827 @default.
• W2007440230 hasConcept C71924100 @default.
• W2007440230 hasConcept C86803240 @default.
• W2007440230 hasConcept C89423630 @default.
• W2007440230 hasConcept C94665300 @default.
• W2007440230 hasConceptScore W2007440230C114851261 @default.
• W2007440230 hasConceptScore W2007440230C174802600 @default.
• W2007440230 hasConceptScore W2007440230C176947019 @default.
• W2007440230 hasConceptScore W2007440230C190139176 @default.
• W2007440230 hasConceptScore W2007440230C2776520383 @default.
• W2007440230 hasConceptScore W2007440230C2778063948 @default.
• W2007440230 hasConceptScore W2007440230C2778243283 @default.
• W2007440230 hasConceptScore W2007440230C2778512257 @default.
• W2007440230 hasConceptScore W2007440230C2779166590 @default.
• W2007440230 hasConceptScore W2007440230C2780493024 @default.
• W2007440230 hasConceptScore W2007440230C2780923616 @default.
• W2007440230 hasConceptScore W2007440230C4937899 @default.
• W2007440230 hasConceptScore W2007440230C501593827 @default.
• W2007440230 hasConceptScore W2007440230C71924100 @default.
• W2007440230 hasConceptScore W2007440230C86803240 @default.
• W2007440230 hasConceptScore W2007440230C89423630 @default.
• W2007440230 hasConceptScore W2007440230C94665300 @default.
• W2007440230 hasIssue "1" @default.
• W2007440230 hasLocation W20074402301 @default.
• W2007440230 hasLocation W20074402302 @default.
• W2007440230 hasLocation W20074402303 @default.
• W2007440230 hasLocation W20074402304 @default.
• W2007440230 hasLocation W20074402305 @default.
• W2007440230 hasOpenAccess W2007440230 @default.

• next