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- W2007448045 abstract "DISC-1 gene may predispose to neurodevelopmental changes underlying schizophrenia Genetic predisposition to schizophrenia is evident from family, twin, and adoption studies.1–3 But whereas genetic factors contribute to the fundamental mechanisms or vulnerability to schizophrenia, additional influences including environmental factors are clearly involved in the full manifestation of symptoms of schizophrenia.4 Thus currently schizophrenia is best conceptualised as a “multiple hit” illness similar to cancer. This editorial looks at the fundamental mechanisms underlying the disease.The following evidence implies that neurodevelopmental abnormalities contribute to susceptibility to schizophrenia.1 5 6 7 Firstly, clinical studies show that patients with schizophrenia manifest minor behavioural abnormalities in childhood even before the onset of schizophrenia.Secondly, recent advanced imaging techniques such as magnetic resonance imaging provide reliable evidence of abnormalities during development of the central nervous system. Such abnormalities include consistent increases in ventricular size at the onset of schizophrenia, with notable alterations in some areas including the prefrontal cerebral cortex and hippocampus.Thirdly, neuropathological studies …" @default.
- W2007448045 created "2016-06-24" @default.
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- W2007448045 date "2003-09-20" @default.
- W2007448045 modified "2023-09-27" @default.
- W2007448045 title "Elucidating the pathogenesis of schizophrenia" @default.
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- W2007448045 doi "https://doi.org/10.1136/bmj.327.7416.632" @default.
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