FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007448051> ?p ?o ?g. }

• W2007448051 endingPage "2102" @default.
• W2007448051 startingPage "2087" @default.
• W2007448051 abstract "Abstract The molecular mechanisms and metabolic pathways whereby the citrus flavonoid, naringenin, reduces dyslipidemia and improves glucose tolerance were investigated in C57BL6/J wild-type mice and fibroblast growth factor 21 (FGF21) null (Fgf21−/−) mice. FGF21 regulates energy homeostasis and the metabolic adaptation to fasting. One avenue of this regulation is through induction of peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc1a), a regulator of hepatic fatty acid oxidation and ketogenesis. Because naringenin is a potent activator of hepatic FA oxidation, we hypothesized that induction of FGF21 might be an integral part of naringenin's mechanism of action. Furthermore, we predicted that FGF21 deficiency would potentiate high-fat diet (HFD)-induced metabolic dysregulation and compromise metabolic protection by naringenin. The absence of FGF21 exacerbated the response to a HFD. Interestingly, naringenin supplementation to the HFD robustly prevented obesity in both genotypes. Gene expression analysis suggested that naringenin was not primarily targeting fatty acid metabolism in white adipose tissue. Naringenin corrected hepatic triglyceride concentrations and normalized hepatic expression of Pgc1a, Cpt1a, and Srebf1c in both wild-type and Fgf21−/− mice. HFD-fed Fgf21−/− mice displayed greater muscle triglyceride deposition, hyperinsulinemia, and impaired glucose tolerance as compared with wild-type mice, confirming the role of FGF21 in insulin sensitivity; however, naringenin supplementation improved these metabolic parameters in both genotypes. We conclude that FGF21 deficiency exacerbates HFD-induced obesity, hepatic steatosis, and insulin resistance. Furthermore, FGF21 is not required for naringenin to protect mice from HFD-induced metabolic dysregulation. Collectively these studies support the concept that naringenin has potent lipid-lowering effects and may act as an insulin sensitizer in vivo." @default.
• W2007448051 created "2016-06-24" @default.
• W2007448051 creator A5003366843 @default.
• W2007448051 creator A5012742246 @default.
• W2007448051 creator A5014041017 @default.
• W2007448051 creator A5014661710 @default.
• W2007448051 creator A5024168823 @default.
• W2007448051 creator A5040885240 @default.
• W2007448051 creator A5046009433 @default.
• W2007448051 creator A5047964091 @default.
• W2007448051 creator A5068454785 @default.
• W2007448051 creator A5071725615 @default.
• W2007448051 creator A5076251127 @default.
• W2007448051 creator A5077211924 @default.
• W2007448051 date "2015-06-01" @default.
• W2007448051 modified "2023-10-02" @default.
• W2007448051 title "Naringenin Prevents Obesity, Hepatic Steatosis, and Glucose Intolerance in Male Mice Independent of Fibroblast Growth Factor 21" @default.
• W2007448051 cites W1634427607 @default.
• W2007448051 cites W1964063591 @default.
• W2007448051 cites W1969363988 @default.
• W2007448051 cites W1978136788 @default.
• W2007448051 cites W1979340145 @default.
• W2007448051 cites W1983397453 @default.
• W2007448051 cites W1993235686 @default.
• W2007448051 cites W2000665430 @default.
• W2007448051 cites W2003905949 @default.
• W2007448051 cites W2010895111 @default.
• W2007448051 cites W2014671368 @default.
• W2007448051 cites W2015339950 @default.
• W2007448051 cites W2018734773 @default.
• W2007448051 cites W2020958481 @default.
• W2007448051 cites W2032787352 @default.
• W2007448051 cites W2035383016 @default.
• W2007448051 cites W2042911346 @default.
• W2007448051 cites W2043106623 @default.
• W2007448051 cites W2048411348 @default.
• W2007448051 cites W2060734703 @default.
• W2007448051 cites W2061333499 @default.
• W2007448051 cites W2062769455 @default.
• W2007448051 cites W2078721766 @default.
• W2007448051 cites W2084062672 @default.
• W2007448051 cites W2086624706 @default.
• W2007448051 cites W2091471695 @default.
• W2007448051 cites W2095480970 @default.
• W2007448051 cites W2096478712 @default.
• W2007448051 cites W2096949413 @default.
• W2007448051 cites W2099784932 @default.
• W2007448051 cites W2100232436 @default.
• W2007448051 cites W2102862906 @default.
• W2007448051 cites W2106986971 @default.
• W2007448051 cites W2110534048 @default.
• W2007448051 cites W2110714384 @default.
• W2007448051 cites W2111653877 @default.
• W2007448051 cites W2114650931 @default.
• W2007448051 cites W2119331212 @default.
• W2007448051 cites W2120257329 @default.
• W2007448051 cites W2122691717 @default.
• W2007448051 cites W2126188293 @default.
• W2007448051 cites W2128519218 @default.
• W2007448051 cites W2130700195 @default.
• W2007448051 cites W2131622156 @default.
• W2007448051 cites W2136477171 @default.
• W2007448051 cites W2139452495 @default.
• W2007448051 cites W2143104968 @default.
• W2007448051 cites W2145044799 @default.
• W2007448051 cites W2145142659 @default.
• W2007448051 cites W2147090946 @default.
• W2007448051 cites W2147734839 @default.
• W2007448051 cites W2149098343 @default.
• W2007448051 cites W2155010729 @default.
• W2007448051 cites W2156982258 @default.
• W2007448051 cites W2158477352 @default.
• W2007448051 cites W2162992895 @default.
• W2007448051 cites W2165852917 @default.
• W2007448051 cites W2166292243 @default.
• W2007448051 cites W2170065584 @default.
• W2007448051 cites W2171175832 @default.
• W2007448051 cites W4235401537 @default.
• W2007448051 doi "https://doi.org/10.1210/en.2014-2003" @default.
• W2007448051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25774553" @default.
• W2007448051 hasPublicationYear "2015" @default.
• W2007448051 type Work @default.
• W2007448051 sameAs 2007448051 @default.
• W2007448051 citedByCount "77" @default.
• W2007448051 countsByYear W20074480512015 @default.
• W2007448051 countsByYear W20074480512016 @default.
• W2007448051 countsByYear W20074480512017 @default.
• W2007448051 countsByYear W20074480512018 @default.
• W2007448051 countsByYear W20074480512019 @default.
• W2007448051 countsByYear W20074480512020 @default.
• W2007448051 countsByYear W20074480512021 @default.
• W2007448051 countsByYear W20074480512022 @default.
• W2007448051 countsByYear W20074480512023 @default.
• W2007448051 crossrefType "journal-article" @default.
• W2007448051 hasAuthorship W2007448051A5003366843 @default.
• W2007448051 hasAuthorship W2007448051A5012742246 @default.
• W2007448051 hasAuthorship W2007448051A5014041017 @default.
• W2007448051 hasAuthorship W2007448051A5014661710 @default.

• next