Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007448460> ?p ?o ?g. }
- W2007448460 endingPage "176" @default.
- W2007448460 startingPage "169" @default.
- W2007448460 abstract "Chronic treatment with basic fibroblast growth factor (bFGF) increases the expression of functional L-type voltage-dependent Ca2+ channels (VDCCs) in fetal rat hippocampal neurons. We investigated the intracellular signaling mechanisms involved in this effect, using high K+ depolarization-induced elevation of intracellular Ca2+ concentrations as a measure. Genistein, a protein tyrosine kinase inhibitor, significantly attenuated the effect of bFGF. The effect of bFGF was also diminished by concurrent application of a Ras inactivator, N-acetyl-S-farnesyl-l-cysteine. In contrast, a phospholipase C inhibitor U73122, a phosphatidylinositol-3 kinase inhibitor wortmannin, Li+ which inhibits inositol phospholipid turnover, or a protein kinase inhibitor calphostin C did not inhibit the effect of bFGF. Phorbol 12-myristate 13-acetate, a protein kinase C activator, did not mimic the effect of bFGF. On the other hand, an adenylyl cyclase activator forskolin and a cyclic AMP analog 8-Br-cyclic AMP markedly attenuated the effect of bFGF, which indicates the presence of a cyclic AMP-mediated negative regulatory mechanism, possibly the interference of Ras–Raf interaction. These results suggest that Ras-mediated signal transduction is required for the enhancement by bFGF of VDCC responses in hippocampal neurons." @default.
- W2007448460 created "2016-06-24" @default.
- W2007448460 creator A5003240537 @default.
- W2007448460 creator A5061663577 @default.
- W2007448460 creator A5088683710 @default.
- W2007448460 creator A5089074853 @default.
- W2007448460 date "1998-12-01" @default.
- W2007448460 modified "2023-10-03" @default.
- W2007448460 title "A potential role of Ras-mediated signal transduction for the enhancement of depolarization-induced Ca2+ responses in hippocampal neurons by basic fibroblast growth factor" @default.
- W2007448460 cites W1522954144 @default.
- W2007448460 cites W1548272930 @default.
- W2007448460 cites W1557874430 @default.
- W2007448460 cites W1572954385 @default.
- W2007448460 cites W1585517331 @default.
- W2007448460 cites W1873545359 @default.
- W2007448460 cites W1890507836 @default.
- W2007448460 cites W1966548950 @default.
- W2007448460 cites W1966600531 @default.
- W2007448460 cites W1969785844 @default.
- W2007448460 cites W1976849281 @default.
- W2007448460 cites W1977311938 @default.
- W2007448460 cites W1984532381 @default.
- W2007448460 cites W1989480480 @default.
- W2007448460 cites W1993876642 @default.
- W2007448460 cites W1995819749 @default.
- W2007448460 cites W1999012962 @default.
- W2007448460 cites W2003347015 @default.
- W2007448460 cites W2003632139 @default.
- W2007448460 cites W2005529016 @default.
- W2007448460 cites W2007261940 @default.
- W2007448460 cites W2012677818 @default.
- W2007448460 cites W2017100096 @default.
- W2007448460 cites W2019687915 @default.
- W2007448460 cites W2022191664 @default.
- W2007448460 cites W2028067698 @default.
- W2007448460 cites W2030213176 @default.
- W2007448460 cites W2033027472 @default.
- W2007448460 cites W2045876058 @default.
- W2007448460 cites W2061304971 @default.
- W2007448460 cites W2072365286 @default.
- W2007448460 cites W2075473225 @default.
- W2007448460 cites W2078317417 @default.
- W2007448460 cites W2085968319 @default.
- W2007448460 cites W2101508825 @default.
- W2007448460 cites W2115484963 @default.
- W2007448460 cites W2148998113 @default.
- W2007448460 cites W2166306472 @default.
- W2007448460 cites W2180005201 @default.
- W2007448460 cites W2247098456 @default.
- W2007448460 cites W3098228429 @default.
- W2007448460 doi "https://doi.org/10.1016/s0165-3806(98)00134-5" @default.
- W2007448460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9838095" @default.
- W2007448460 hasPublicationYear "1998" @default.
- W2007448460 type Work @default.
- W2007448460 sameAs 2007448460 @default.
- W2007448460 citedByCount "8" @default.
- W2007448460 countsByYear W20074484602016 @default.
- W2007448460 crossrefType "journal-article" @default.
- W2007448460 hasAuthorship W2007448460A5003240537 @default.
- W2007448460 hasAuthorship W2007448460A5061663577 @default.
- W2007448460 hasAuthorship W2007448460A5088683710 @default.
- W2007448460 hasAuthorship W2007448460A5089074853 @default.
- W2007448460 hasConcept C126322002 @default.
- W2007448460 hasConcept C134018914 @default.
- W2007448460 hasConcept C170493617 @default.
- W2007448460 hasConcept C195794163 @default.
- W2007448460 hasConcept C24998067 @default.
- W2007448460 hasConcept C2775960820 @default.
- W2007448460 hasConcept C2777587049 @default.
- W2007448460 hasConcept C2778308172 @default.
- W2007448460 hasConcept C2778597717 @default.
- W2007448460 hasConcept C2779178603 @default.
- W2007448460 hasConcept C2779276759 @default.
- W2007448460 hasConcept C2780245509 @default.
- W2007448460 hasConcept C2780610907 @default.
- W2007448460 hasConcept C2781168148 @default.
- W2007448460 hasConcept C55493867 @default.
- W2007448460 hasConcept C62478195 @default.
- W2007448460 hasConcept C71924100 @default.
- W2007448460 hasConcept C86803240 @default.
- W2007448460 hasConcept C88045685 @default.
- W2007448460 hasConcept C95444343 @default.
- W2007448460 hasConceptScore W2007448460C126322002 @default.
- W2007448460 hasConceptScore W2007448460C134018914 @default.
- W2007448460 hasConceptScore W2007448460C170493617 @default.
- W2007448460 hasConceptScore W2007448460C195794163 @default.
- W2007448460 hasConceptScore W2007448460C24998067 @default.
- W2007448460 hasConceptScore W2007448460C2775960820 @default.
- W2007448460 hasConceptScore W2007448460C2777587049 @default.
- W2007448460 hasConceptScore W2007448460C2778308172 @default.
- W2007448460 hasConceptScore W2007448460C2778597717 @default.
- W2007448460 hasConceptScore W2007448460C2779178603 @default.
- W2007448460 hasConceptScore W2007448460C2779276759 @default.
- W2007448460 hasConceptScore W2007448460C2780245509 @default.
- W2007448460 hasConceptScore W2007448460C2780610907 @default.
- W2007448460 hasConceptScore W2007448460C2781168148 @default.
- W2007448460 hasConceptScore W2007448460C55493867 @default.
- W2007448460 hasConceptScore W2007448460C62478195 @default.