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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007448752> ?p ?o ?g. }

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• W2007448752 abstract "Helicobacter pylori is a human pathogen that colonizes about 50% of the world's population, causing chronic gastritis, duodenal ulcers and even gastric cancer. A steady emergence of multiple antibiotic resistant strains poses an important public health threat and there is an urgent requirement for alternative therapeutics. The blood group antigen-binding adhesin BabA mediates the intimate attachment to the host mucosa and forms a major candidate for novel vaccine and drug development. Here, the recombinant expression and crystallization of a soluble BabA truncation (BabA 25–460 ) corresponding to the predicted extracellular adhesin domain of the protein are reported. X-ray diffraction data for nanobody-stabilized BabA 25–460 were collected to 2.25 Å resolution from a crystal that belonged to space group P 2 1 , with unit-cell parameters a = 50.96, b = 131.41, c = 123.40 Å, α = 90.0, β = 94.8, γ = 90.0°, and which was predicted to contain two BabA 25–460 –nanobody complexes per asymmetric unit." @default.
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• W2007448752 date "2014-11-14" @default.
• W2007448752 modified "2023-09-27" @default.
• W2007448752 title "Expression, purification and X-ray crystallographic analysis of the<i>Helicobacter pylori</i>blood group antigen-binding adhesin BabA" @default.
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• W2007448752 doi "https://doi.org/10.1107/s2053230x14023188" @default.
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