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• W2007458370 abstract "1 In the non-steady state of moderate intensity exercise, pulmonary O2 uptake (V̇p,O2) is temporally dissociated from muscle O2 consumption (V̇m,O2) due to the influence of the intervening venous blood volume and the contribution of body O2 stores to ATP synthesis. A monoexponential model of V̇p,O2 without a delay term, therefore, implies an obligatory slowing of V̇p,O2 kinetics in comparison to V̇m,O2. 2 During moderate exercise, an association of V̇m,O2 and [phosphocreatine] ([PCr]) kinetics is a necessary consequence of the control of muscular oxidative phosphorylation mediated by some function of [PCr]. It has also been suggested that the kinetics of V̇p,O2 will be expressed with a time constant within 10 % of that of V̇m,O2. 3 V̇p,O2 and intramuscular [PCr] kinetics were investigated simultaneously during moderate exercise of a large muscle mass in a whole-body NMR spectrometer. Six healthy males performed prone constant-load quadriceps exercise. A transmit-receive coil under the right quadriceps allowed determination of intramuscular [PCr]; V̇p,O2 was measured breath-by-breath, in concert with [PCr], using a turbine and a mass spectrometer system. 4 Intramuscular [PCr] decreased monoexponentially with no delay in response to exercise. The mean of the time constants (τPCr) was 35 s (range, 20–64 s) for the six subjects. 5 Two temporal phases were evident in the V̇p,O2 response. When the entire V̇p,O2 response was modelled to be exponential with no delay, its time constant (τ′V̇p,O2) was longer in all subjects (group mean = 62 s; range, 52–92 s) than that of [PCr], reflecting the energy contribution of the O2 stores. 6 Restricting the V̇p,O2 model fit to phase II resulted in matching kinetics for V̇p,O2 (group mean τV̇p,O2= 36 s; range, 20–68 s) and [PCr], for all subjects. 7 We conclude that during moderate intensity exercise the phase II τV̇p,O2 provides a good estimate of τPCr and by implication that of V̇m,O2 (τV̇m,O2)." @default.
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• W2007458370 date "1999-08-01" @default.
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• W2007458370 title "Inferences from pulmonary O₂ uptake with respect to intramuscular [phosphocreatine] kinetics during moderate exercise in humans" @default.
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• W2007458370 doi "https://doi.org/10.1111/j.1469-7793.1999.0921p.x" @default.
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