Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007459512> ?p ?o ?g. }
- W2007459512 endingPage "684" @default.
- W2007459512 startingPage "670" @default.
- W2007459512 abstract "Omalizumab is the first licensed anti-immunoglobulin (Ig) E antibody shown to be effective for treatment of allergic (IgE-mediated) asthma. Recent international guidelines recommend omalizumab as add-on treatment to fixed dose inhaled corticosteroid (ICS) and long-acting beta(2)-agonist (LABA) combination therapy. However, omalizumab is more expensive than other current asthma treatments and health and reimbursement authorities are increasingly demanding evidence of economic benefit to support pricing and formulary listing. The aims of this article are to (i) summarize data on the human and economic burden of severe asthma, (ii) summarize the efficacy data obtained for omalizumab in clinical trials in patients with inadequately controlled severe persistent allergic asthma despite high-dose ICS plus a LABA, and (iii) discuss the cost-effectiveness evidence published for omalizumab in this patient population. A wealth of evidence exists highlighting that the health, economic and societal burden of asthma is considerable and is highly skewed towards patients with severe asthma, particularly when asthma is inadequately controlled. Omalizumab is clinically beneficial in patients with severe persistent allergic asthma despite high-dose ICS plus a LABA, particularly in a subgroup of patients who respond to therapy. In patients who respond to therapy, the cost-effectiveness of omalizumab compares well with other biologic treatments for chronic illness." @default.
- W2007459512 created "2016-06-24" @default.
- W2007459512 creator A5032325756 @default.
- W2007459512 creator A5050079870 @default.
- W2007459512 date "2008-04-25" @default.
- W2007459512 modified "2023-10-10" @default.
- W2007459512 title "An evaluation of the cost-effectiveness of omalizumab for the treatment of severe allergic asthma" @default.
- W2007459512 cites W1218690527 @default.
- W2007459512 cites W1561496887 @default.
- W2007459512 cites W1967215794 @default.
- W2007459512 cites W1971540463 @default.
- W2007459512 cites W1976065152 @default.
- W2007459512 cites W1979554096 @default.
- W2007459512 cites W1980602104 @default.
- W2007459512 cites W1986155917 @default.
- W2007459512 cites W1987444459 @default.
- W2007459512 cites W1989781627 @default.
- W2007459512 cites W1990704583 @default.
- W2007459512 cites W1992830319 @default.
- W2007459512 cites W1995784152 @default.
- W2007459512 cites W2000665481 @default.
- W2007459512 cites W2001446148 @default.
- W2007459512 cites W2013051331 @default.
- W2007459512 cites W2015105473 @default.
- W2007459512 cites W2016897534 @default.
- W2007459512 cites W2016963118 @default.
- W2007459512 cites W2018241075 @default.
- W2007459512 cites W2021351287 @default.
- W2007459512 cites W2029587541 @default.
- W2007459512 cites W2030556594 @default.
- W2007459512 cites W2031040861 @default.
- W2007459512 cites W2034683372 @default.
- W2007459512 cites W2038987444 @default.
- W2007459512 cites W2039337853 @default.
- W2007459512 cites W2043990114 @default.
- W2007459512 cites W2049530877 @default.
- W2007459512 cites W2053199643 @default.
- W2007459512 cites W2054060007 @default.
- W2007459512 cites W2055220989 @default.
- W2007459512 cites W2060497576 @default.
- W2007459512 cites W2065855120 @default.
- W2007459512 cites W2068195088 @default.
- W2007459512 cites W2070763554 @default.
- W2007459512 cites W2071252658 @default.
- W2007459512 cites W2073321077 @default.
- W2007459512 cites W2074344385 @default.
- W2007459512 cites W2076114528 @default.
- W2007459512 cites W2079229667 @default.
- W2007459512 cites W2080649045 @default.
- W2007459512 cites W2088383784 @default.
- W2007459512 cites W2088710460 @default.
- W2007459512 cites W2097585904 @default.
- W2007459512 cites W2097981132 @default.
- W2007459512 cites W2098522960 @default.
- W2007459512 cites W2099765814 @default.
- W2007459512 cites W2103541662 @default.
- W2007459512 cites W2110052844 @default.
- W2007459512 cites W2110579070 @default.
- W2007459512 cites W2110921365 @default.
- W2007459512 cites W2122889483 @default.
- W2007459512 cites W2128690134 @default.
- W2007459512 cites W2129649074 @default.
- W2007459512 cites W2130946946 @default.
- W2007459512 cites W2134342836 @default.
- W2007459512 cites W2134363311 @default.
- W2007459512 cites W2135340380 @default.
- W2007459512 cites W2145893088 @default.
- W2007459512 cites W2148583736 @default.
- W2007459512 cites W2149338618 @default.
- W2007459512 cites W2156916462 @default.
- W2007459512 cites W2157110651 @default.
- W2007459512 cites W2157354669 @default.
- W2007459512 cites W2158323220 @default.
- W2007459512 cites W2163779250 @default.
- W2007459512 cites W2166258038 @default.
- W2007459512 cites W2168197400 @default.
- W2007459512 cites W2168250184 @default.
- W2007459512 cites W2170872741 @default.
- W2007459512 cites W2171331726 @default.
- W2007459512 cites W2308777632 @default.
- W2007459512 doi "https://doi.org/10.1111/j.1398-9995.2008.01723.x" @default.
- W2007459512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18445184" @default.
- W2007459512 hasPublicationYear "2008" @default.
- W2007459512 type Work @default.
- W2007459512 sameAs 2007459512 @default.
- W2007459512 citedByCount "59" @default.
- W2007459512 countsByYear W20074595122012 @default.
- W2007459512 countsByYear W20074595122013 @default.
- W2007459512 countsByYear W20074595122014 @default.
- W2007459512 countsByYear W20074595122015 @default.
- W2007459512 countsByYear W20074595122016 @default.
- W2007459512 countsByYear W20074595122017 @default.
- W2007459512 countsByYear W20074595122018 @default.
- W2007459512 countsByYear W20074595122019 @default.
- W2007459512 countsByYear W20074595122020 @default.
- W2007459512 countsByYear W20074595122022 @default.
- W2007459512 countsByYear W20074595122023 @default.
- W2007459512 crossrefType "journal-article" @default.