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- W2007460019 abstract "Objective: A strong prognostic indicator, the existence of channels of bare extracellular matrix or channels lined with tumor cells, has been found in an increasing number of tumors (melanoma, breast, prostate). This study explores the use of echogenic liposomes and echogenic immunoliposomes to examine the possibility of an extra-vascular flow component that could provide a secondary source for metabolic function and egress of cells with metastatic potential. Methods: Echogenic liposomes with and without a fluorchrome lipid component, and with and without antibody decoration (anti-vitronectin, anti-elastin) were produced and maintained in the fluffy-cake lyophilized state prior to rehydration immediately before use. Human tumor xenografts (C918 human uveal melanoma model) in the BALB/c nu/nu mouse were grown to an approximate volume of 1200 mm3. Mice were tail vein catheterized, anesthetized, depilitated, and placed in a high-frequency (37-MHz center frequency, 10–60 −15 db bandwidth) multi-axis immersion scanning system. Serial digital RF scans were acquired before, during, and after bolus injection of liposomes. Typical scan parameters were 512 lines of 2048 samples at 250 MHz. Calibrated ensemble-averaged power spectrum parameters (cq2, size, and mid-band fit) and ultrasound parameter images were compared with a tunable laser confocal microscopy of frozen and fixed sections of tumors sectioned in the same scan planes as the RF data and stained to identify extracellular matrix structures Results: Bolus immunoliposome injection in the murine xenograft model produces a persistent increase of ∼2 db in mid-band fit and is spatially localized in vessels and other areas in tumors. Phosphor tagged liposomes can be detected in patent vessels and in proximity to labeled extracellular matrix structures. Conclusions: Echogenic immunoliposomes can detect the presence of extracellular matrix proteins in this model. While the murine xenograft model lacks a realistic extracellular matrix pattern microarchitecture due to the lack of environmental modulators, the results suggest that echogenic liposomes could be used in-vivo to detect the presence of these patterns." @default.
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- W2007460019 date "2003-05-01" @default.
- W2007460019 modified "2023-10-02" @default.
- W2007460019 title "Echogenic liposomes and secondary flow through extracelluar matrix and mosaic channels" @default.
- W2007460019 doi "https://doi.org/10.1016/s0301-5629(03)00459-9" @default.
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