FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007461106> ?p ?o ?g. }

• W2007461106 endingPage "2440" @default.
• W2007461106 startingPage "2427" @default.
• W2007461106 abstract "Galactosamine (galN) is widely used as an in vivo model of acute liver injury. We have applied an integrative approach, combining histopathology, clinical chemistry, cytokine analysis, and nuclear magnetic resonance (NMR) spectroscopic metabolic profiling of biofluids and tissues, to study variability in response to galactosamine following successive dosing. On re-challenge with galN, primary non-responders displayed galN-induced hepatotoxicity (induced response), whereas primary responders exhibited a less marked response (adaptive response). A systems-level metabonomic approach enabled simultaneous characterization of the xenobiotic and endogenous metabolic perturbations associated with the different response phenotypes. Elevated serum cytokines were identified and correlated with hepatic metabolic profiles to further investigate the inflammatory response to galN. The presence of urinary N-acetylglucosamine (glcNAc) correlated with toxicological outcome and reflected the dynamic shift from a resistant to a sensitive phenotype (induced response). In addition, the urinary level of glcNAc and hepatic level of UDP-N-acetylhexosamines reflected an adaptive response to galN. The unique observation of galN-pyrazines and altered gut microbial metabolites in fecal profiles of non-responders suggested that gut microfloral metabolism was associated with toxic outcome. Pharmacometabonomic modeling of predose urinary and fecal NMR spectroscopic profiles revealed a diverse panel of metabolites that classified the dynamic shift between a resistant and sensitive phenotype. This integrative pharmacometabonomic approach has been demonstrated for a model toxin; however, it is equally applicable to xenobiotic interventions that are associated with wide variation in efficacy or toxicity and, in particular, for prediction of susceptibility to toxicity." @default.
• W2007461106 created "2016-06-24" @default.
• W2007461106 creator A5009367519 @default.
• W2007461106 creator A5009901038 @default.
• W2007461106 creator A5018207002 @default.
• W2007461106 creator A5028056295 @default.
• W2007461106 creator A5037616278 @default.
• W2007461106 creator A5058903456 @default.
• W2007461106 creator A5060173548 @default.
• W2007461106 creator A5069972235 @default.
• W2007461106 date "2012-03-02" @default.
• W2007461106 modified "2023-10-11" @default.
• W2007461106 title "Pharmacometabonomic Investigation of Dynamic Metabolic Phenotypes Associated with Variability in Response to Galactosamine Hepatotoxicity" @default.
• W2007461106 cites W1483159264 @default.
• W2007461106 cites W1516522009 @default.
• W2007461106 cites W1545718209 @default.
• W2007461106 cites W1597273370 @default.
• W2007461106 cites W1606088617 @default.
• W2007461106 cites W1747625137 @default.
• W2007461106 cites W1748859686 @default.
• W2007461106 cites W1895993106 @default.
• W2007461106 cites W1934624334 @default.
• W2007461106 cites W1966604634 @default.
• W2007461106 cites W1968593126 @default.
• W2007461106 cites W1969779341 @default.
• W2007461106 cites W1969879564 @default.
• W2007461106 cites W1973654506 @default.
• W2007461106 cites W1973686253 @default.
• W2007461106 cites W1973829843 @default.
• W2007461106 cites W1973887423 @default.
• W2007461106 cites W1978619016 @default.
• W2007461106 cites W1985130551 @default.
• W2007461106 cites W1995192295 @default.
• W2007461106 cites W1999299740 @default.
• W2007461106 cites W2005804271 @default.
• W2007461106 cites W2018219757 @default.
• W2007461106 cites W2018553398 @default.
• W2007461106 cites W2019859514 @default.
• W2007461106 cites W2020423296 @default.
• W2007461106 cites W2022626022 @default.
• W2007461106 cites W2029648184 @default.
• W2007461106 cites W2036411298 @default.
• W2007461106 cites W2038181377 @default.
• W2007461106 cites W2043717441 @default.
• W2007461106 cites W2051366884 @default.
• W2007461106 cites W2059098946 @default.
• W2007461106 cites W2060368615 @default.
• W2007461106 cites W2060952451 @default.
• W2007461106 cites W2061156796 @default.
• W2007461106 cites W2066775313 @default.
• W2007461106 cites W2067752954 @default.
• W2007461106 cites W2068861578 @default.
• W2007461106 cites W2069588725 @default.
• W2007461106 cites W2080302529 @default.
• W2007461106 cites W2080505802 @default.
• W2007461106 cites W2080755591 @default.
• W2007461106 cites W2083637865 @default.
• W2007461106 cites W2084608143 @default.
• W2007461106 cites W2088600952 @default.
• W2007461106 cites W2092289140 @default.
• W2007461106 cites W2093064281 @default.
• W2007461106 cites W2105479208 @default.
• W2007461106 cites W2107228070 @default.
• W2007461106 cites W2107568445 @default.
• W2007461106 cites W2108313429 @default.
• W2007461106 cites W2112610029 @default.
• W2007461106 cites W2123727902 @default.
• W2007461106 cites W2123934362 @default.
• W2007461106 cites W2126297967 @default.
• W2007461106 cites W2136780652 @default.
• W2007461106 cites W2137107070 @default.
• W2007461106 cites W2144956608 @default.
• W2007461106 cites W2146402650 @default.
• W2007461106 cites W2147232469 @default.
• W2007461106 cites W2152627125 @default.
• W2007461106 cites W2154168697 @default.
• W2007461106 cites W2156395253 @default.
• W2007461106 cites W2167377418 @default.
• W2007461106 cites W2170158942 @default.
• W2007461106 cites W2399617529 @default.
• W2007461106 cites W384075993 @default.
• W2007461106 cites W2018411317 @default.
• W2007461106 doi "https://doi.org/10.1021/pr201161f" @default.
• W2007461106 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22384821" @default.
• W2007461106 hasPublicationYear "2012" @default.
• W2007461106 type Work @default.
• W2007461106 sameAs 2007461106 @default.
• W2007461106 citedByCount "32" @default.
• W2007461106 countsByYear W20074611062012 @default.
• W2007461106 countsByYear W20074611062013 @default.
• W2007461106 countsByYear W20074611062014 @default.
• W2007461106 countsByYear W20074611062015 @default.
• W2007461106 countsByYear W20074611062016 @default.
• W2007461106 countsByYear W20074611062017 @default.
• W2007461106 countsByYear W20074611062019 @default.
• W2007461106 countsByYear W20074611062021 @default.
• W2007461106 countsByYear W20074611062022 @default.
• W2007461106 crossrefType "journal-article" @default.

• next