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• W2007461928 endingPage "450" @default.
• W2007461928 startingPage "439" @default.
• W2007461928 abstract "In Brief Migraine is a common and disabling neurologic disorder, with important psychiatric comorbidities. Its pathophysiology involves activation of neurons in the trigeminocervical complex (TCC). Kainate receptors carrying the glutamate receptor subunit 5 (GluK1) are present in key brain areas involved in migraine pathophysiology. To study the influence of kainate receptors on trigeminovascular neurotransmission, we determined the presence of GluK1 receptors within the trigeminal ganglion and TCC with immunohistochemistry. We performed in vivo electrophysiologic recordings from TCC neurons and investigated whether local or systemic application of GluK1 receptor antagonists modulated trigeminovascular transmission. Microiontophoretic application of a selective GluK1 receptor antagonist, but not of a nonspecific ionotropic glutamate receptor antagonist, markedly attenuated cell firing in a subpopulation of neurons activated in response to dural stimulation, consistent with selective inhibition of postsynaptic GluK1 receptor–evoked firing seen in all recorded neurons. In contrast, trigeminovascular activation was significantly facilitated in a different neuronal population. The clinically active kainate receptor antagonist LY466195 attenuated trigeminovascular activation in all neurons. In addition, LY466195 demonstrated an N-methyl-d-aspartate receptor–mediated effect. This study demonstrates a differential role of GluK1 receptors in the TCC, antagonism of which can inhibit trigeminovascular activation through postsynaptic mechanisms. Furthermore, the data suggest a novel, possibly presynaptic, modulatory role of trigeminocervical kainate receptors in vivo. Differential activation of kainate receptors suggests unique roles for this receptor in pro- and antinociceptive mechanisms in migraine pathophysiology. The data suggest a novel, possibly presynaptic, role of trigeminocervical kainate receptors in vivo. Differential activation of kainate receptors suggests a unique potential role in migraine." @default.
• W2007461928 created "2016-06-24" @default.
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• W2007461928 date "2015-03-01" @default.
• W2007461928 modified "2023-09-26" @default.
• W2007461928 title "Modulation of nociceptive dural input to the trigeminocervical complex through GluK1 kainate receptors" @default.
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• W2007461928 doi "https://doi.org/10.1097/01.j.pain.0000460325.25762.c0" @default.
• W2007461928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7611087" @default.
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• W2007461928 hasPublicationYear "2015" @default.
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