FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007464530> ?p ?o ?g. }

• W2007464530 endingPage "21" @default.
• W2007464530 startingPage "9" @default.
• W2007464530 abstract "Signaling pathways involving phospholipase C (PLC) are involved in various neural functions. Understanding how these pathways are regulated will lead to a better understanding of their roles in neural functions. Previous studies demonstrated that receptor-driven PLCβ activation depends on intracellular Ca(2+) concentration ([Ca(2+)]i), suggesting the possibility that PLCβ-dependent cellular responses are basically Ca(2+) dependent. To test this possibility, we examined whether modulations of ion channels driven by PLC-coupled metabotropic receptors are sensitive to [Ca(2+)]i using cultured hippocampal neurons. Muscarinic activation triggered an inward current at -100 mV (the equilibrium potential for K(+)) in a subpopulation of neurons. This current response was suppressed by pirenzepine (an M1-preferring antagonist), PLC inhibitor, non-selective cation channel blocker, and lowering [Ca(2+)]i. Using the neurons showing no response at -100 mV, effects of muscarinic activation on K(+) channels were examined at -40 mV. Muscarinic activation induced a transient decrease of the holding outward current. This current response was mimicked and occluded by XE991, an M-current K(+) channel blocker, suppressed by pirenzepine, PLC inhibitor and lowering [Ca(2+)]i, and enhanced by elevating [Ca(2+)]i. Similar results were obtained when group I metabotropic glutamate receptors were activated instead of muscarinic receptors. These results clearly show that ion channel modulations driven by PLC-coupled metabotropic receptors are dependent on [Ca(2+)]i, supporting the hypothesis that cellular responses induced by receptor-driven PLCβ activation are basically Ca(2+) dependent." @default.
• W2007464530 created "2016-06-24" @default.
• W2007464530 creator A5018885215 @default.
• W2007464530 creator A5032973605 @default.
• W2007464530 creator A5037329252 @default.
• W2007464530 creator A5052607969 @default.
• W2007464530 creator A5055687091 @default.
• W2007464530 creator A5058223507 @default.
• W2007464530 creator A5075406091 @default.
• W2007464530 creator A5078840485 @default.
• W2007464530 creator A5087016051 @default.
• W2007464530 date "2013-05-01" @default.
• W2007464530 modified "2023-09-30" @default.
• W2007464530 title "Intracellular calcium level is an important factor influencing ion channel modulations by PLC-coupled metabotropic receptors in hippocampal neurons" @default.
• W2007464530 cites W1537329448 @default.
• W2007464530 cites W1561700273 @default.
• W2007464530 cites W1597131590 @default.
• W2007464530 cites W1605503794 @default.
• W2007464530 cites W1664352025 @default.
• W2007464530 cites W1736719008 @default.
• W2007464530 cites W1958742527 @default.
• W2007464530 cites W1963938486 @default.
• W2007464530 cites W1965127680 @default.
• W2007464530 cites W1968083340 @default.
• W2007464530 cites W1981546671 @default.
• W2007464530 cites W1982681520 @default.
• W2007464530 cites W1983664266 @default.
• W2007464530 cites W1986505831 @default.
• W2007464530 cites W1998442807 @default.
• W2007464530 cites W2005291443 @default.
• W2007464530 cites W2018759189 @default.
• W2007464530 cites W2019469176 @default.
• W2007464530 cites W2020173449 @default.
• W2007464530 cites W2020550595 @default.
• W2007464530 cites W2022388123 @default.
• W2007464530 cites W2028985118 @default.
• W2007464530 cites W2029393114 @default.
• W2007464530 cites W2041935019 @default.
• W2007464530 cites W2048997291 @default.
• W2007464530 cites W2049606674 @default.
• W2007464530 cites W2050481377 @default.
• W2007464530 cites W2052082800 @default.
• W2007464530 cites W2055286564 @default.
• W2007464530 cites W2058489268 @default.
• W2007464530 cites W2059690890 @default.
• W2007464530 cites W2061875572 @default.
• W2007464530 cites W2071885606 @default.
• W2007464530 cites W2079373480 @default.
• W2007464530 cites W2082829013 @default.
• W2007464530 cites W2095239151 @default.
• W2007464530 cites W2096549360 @default.
• W2007464530 cites W2112563380 @default.
• W2007464530 cites W2116562654 @default.
• W2007464530 cites W2116903886 @default.
• W2007464530 cites W2118656164 @default.
• W2007464530 cites W2123505183 @default.
• W2007464530 cites W2128426029 @default.
• W2007464530 cites W2129220462 @default.
• W2007464530 cites W2134467167 @default.
• W2007464530 cites W2135639688 @default.
• W2007464530 cites W2142058583 @default.
• W2007464530 cites W2154849166 @default.
• W2007464530 cites W2170571477 @default.
• W2007464530 cites W2170669156 @default.
• W2007464530 cites W4233086719 @default.
• W2007464530 doi "https://doi.org/10.1016/j.brainres.2013.03.040" @default.
• W2007464530 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23548601" @default.
• W2007464530 hasPublicationYear "2013" @default.
• W2007464530 type Work @default.
• W2007464530 sameAs 2007464530 @default.
• W2007464530 citedByCount "6" @default.
• W2007464530 countsByYear W20074645302014 @default.
• W2007464530 countsByYear W20074645302016 @default.
• W2007464530 countsByYear W20074645302023 @default.
• W2007464530 crossrefType "journal-article" @default.
• W2007464530 hasAuthorship W2007464530A5018885215 @default.
• W2007464530 hasAuthorship W2007464530A5032973605 @default.
• W2007464530 hasAuthorship W2007464530A5037329252 @default.
• W2007464530 hasAuthorship W2007464530A5052607969 @default.
• W2007464530 hasAuthorship W2007464530A5055687091 @default.
• W2007464530 hasAuthorship W2007464530A5058223507 @default.
• W2007464530 hasAuthorship W2007464530A5075406091 @default.
• W2007464530 hasAuthorship W2007464530A5078840485 @default.
• W2007464530 hasAuthorship W2007464530A5087016051 @default.
• W2007464530 hasBestOaLocation W20074645302 @default.
• W2007464530 hasConcept C12554922 @default.
• W2007464530 hasConcept C155164980 @default.
• W2007464530 hasConcept C169760540 @default.
• W2007464530 hasConcept C170488646 @default.
• W2007464530 hasConcept C170493617 @default.
• W2007464530 hasConcept C185592680 @default.
• W2007464530 hasConcept C207723603 @default.
• W2007464530 hasConcept C26702167 @default.
• W2007464530 hasConcept C2778597717 @default.
• W2007464530 hasConcept C2778616617 @default.
• W2007464530 hasConcept C33789571 @default.
• W2007464530 hasConcept C49051014 @default.
• W2007464530 hasConcept C55493867 @default.

• next