Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007466478> ?p ?o ?g. }
- W2007466478 endingPage "8988" @default.
- W2007466478 startingPage "8983" @default.
- W2007466478 abstract "Telomeres are specialized structures located at the ends of linear eukaryotic chromosomes that ensure their complete replication and protect them from fusion and degradation. We report here the characterization of the telomeres of the nematode Caenorhabditis elegans. We show that the chromosomes terminate in 4-9 kb of tandem repeats of the sequence TTAGGC. Furthermore, we have isolated clones corresponding to 11 of the 12 C. elegans telomeres. Their subtelomeric sequences are all different from each other, demonstrating that the terminal TTAGGC repeats are sufficient for general chromosomal capping functions. Finally, we demonstrate that the me8 meiotic mutant, which is defective in X chromosome crossing over and segregation, bears a terminal deficiency, that was healed by the addition of telomeric repeats, presumably by the activity of a telomerase enzyme. The 11 cloned telomeres represent an important advance for the completion of the physical map and for the determination of the entire sequence of the C. elegans genome." @default.
- W2007466478 created "2016-06-24" @default.
- W2007466478 creator A5018981641 @default.
- W2007466478 creator A5043953114 @default.
- W2007466478 creator A5060041218 @default.
- W2007466478 creator A5065736924 @default.
- W2007466478 creator A5080614497 @default.
- W2007466478 creator A5086308945 @default.
- W2007466478 date "1996-08-20" @default.
- W2007466478 modified "2023-10-03" @default.
- W2007466478 title "Telomeric repeats (TTAGGC)n are sufficient for chromosome capping function in Caenorhabditis elegans." @default.
- W2007466478 cites W103262423 @default.
- W2007466478 cites W129357095 @default.
- W2007466478 cites W1560248254 @default.
- W2007466478 cites W1582305548 @default.
- W2007466478 cites W1777520221 @default.
- W2007466478 cites W1958677382 @default.
- W2007466478 cites W1969031231 @default.
- W2007466478 cites W1972145114 @default.
- W2007466478 cites W1973706463 @default.
- W2007466478 cites W1975716080 @default.
- W2007466478 cites W1983019299 @default.
- W2007466478 cites W1989645426 @default.
- W2007466478 cites W1991955282 @default.
- W2007466478 cites W1992194142 @default.
- W2007466478 cites W2000238936 @default.
- W2007466478 cites W2002043627 @default.
- W2007466478 cites W2006640982 @default.
- W2007466478 cites W2007663749 @default.
- W2007466478 cites W2013404388 @default.
- W2007466478 cites W2019534744 @default.
- W2007466478 cites W2019802887 @default.
- W2007466478 cites W2023034556 @default.
- W2007466478 cites W2032824523 @default.
- W2007466478 cites W2041806416 @default.
- W2007466478 cites W2044042020 @default.
- W2007466478 cites W2045702252 @default.
- W2007466478 cites W2058197513 @default.
- W2007466478 cites W2062622734 @default.
- W2007466478 cites W2063880804 @default.
- W2007466478 cites W2069333095 @default.
- W2007466478 cites W2089246777 @default.
- W2007466478 cites W2091314517 @default.
- W2007466478 cites W2100822763 @default.
- W2007466478 cites W2105939757 @default.
- W2007466478 cites W2108471057 @default.
- W2007466478 cites W2111502981 @default.
- W2007466478 cites W2122740168 @default.
- W2007466478 cites W2161254135 @default.
- W2007466478 cites W2177878554 @default.
- W2007466478 cites W2410662711 @default.
- W2007466478 cites W4237540956 @default.
- W2007466478 doi "https://doi.org/10.1073/pnas.93.17.8983" @default.
- W2007466478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/38581" @default.
- W2007466478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8799140" @default.
- W2007466478 hasPublicationYear "1996" @default.
- W2007466478 type Work @default.
- W2007466478 sameAs 2007466478 @default.
- W2007466478 citedByCount "102" @default.
- W2007466478 countsByYear W20074664782013 @default.
- W2007466478 countsByYear W20074664782014 @default.
- W2007466478 countsByYear W20074664782015 @default.
- W2007466478 countsByYear W20074664782016 @default.
- W2007466478 countsByYear W20074664782017 @default.
- W2007466478 countsByYear W20074664782018 @default.
- W2007466478 countsByYear W20074664782019 @default.
- W2007466478 countsByYear W20074664782020 @default.
- W2007466478 countsByYear W20074664782021 @default.
- W2007466478 countsByYear W20074664782022 @default.
- W2007466478 countsByYear W20074664782023 @default.
- W2007466478 crossrefType "journal-article" @default.
- W2007466478 hasAuthorship W2007466478A5018981641 @default.
- W2007466478 hasAuthorship W2007466478A5043953114 @default.
- W2007466478 hasAuthorship W2007466478A5060041218 @default.
- W2007466478 hasAuthorship W2007466478A5065736924 @default.
- W2007466478 hasAuthorship W2007466478A5080614497 @default.
- W2007466478 hasAuthorship W2007466478A5086308945 @default.
- W2007466478 hasBestOaLocation W20074664782 @default.
- W2007466478 hasConcept C104317684 @default.
- W2007466478 hasConcept C141231307 @default.
- W2007466478 hasConcept C177336024 @default.
- W2007466478 hasConcept C202265312 @default.
- W2007466478 hasConcept C23069440 @default.
- W2007466478 hasConcept C2778944004 @default.
- W2007466478 hasConcept C30481170 @default.
- W2007466478 hasConcept C54355233 @default.
- W2007466478 hasConcept C552990157 @default.
- W2007466478 hasConcept C86339819 @default.
- W2007466478 hasConcept C86803240 @default.
- W2007466478 hasConcept C94581717 @default.
- W2007466478 hasConcept C94966510 @default.
- W2007466478 hasConceptScore W2007466478C104317684 @default.
- W2007466478 hasConceptScore W2007466478C141231307 @default.
- W2007466478 hasConceptScore W2007466478C177336024 @default.
- W2007466478 hasConceptScore W2007466478C202265312 @default.
- W2007466478 hasConceptScore W2007466478C23069440 @default.
- W2007466478 hasConceptScore W2007466478C2778944004 @default.
- W2007466478 hasConceptScore W2007466478C30481170 @default.