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- W2007470147 abstract "Bioassay-guided fractionation of an antimalarial extract derived from the fungus Ramaria subaurantiaca afforded the known polyamine alkaloid, pistillarin. Nine pistillarin analogues were synthesised via EDC-mediated chemistry and these compounds along with the previously reported natural product polyamines, ianthelliformisamines A–C and spermatinamine, were evaluated against Plasmodium falciparum (3D7) parasites and a normal human cell line to determine parasite-specific activity. Spermatinamine (IC50 0.23 μM) and pistillarin (IC50 1.9 μM) were the two most potent antimalarials identified during these studies." @default.
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- W2007470147 date "2013-09-01" @default.
- W2007470147 modified "2023-10-14" @default.
- W2007470147 title "The discovery, synthesis and antimalarial evaluation of natural product-based polyamine alkaloids" @default.
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- W2007470147 doi "https://doi.org/10.1016/j.tetlet.2013.07.058" @default.
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