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• W2007472328 abstract "Background The Frank-Starling response contributes to the regulation of cardiac output. The major underlying subcellular mechanism is a length-dependent change in myofilament responsiveness to Ca 2+ . Recent studies indicate that nitric oxide decreases myofilament responsiveness to Ca 2+ and modulates myocardial relaxation and left ventricular (LV) diastolic function. We therefore investigated the interaction between nitric oxide and the Frank-Starling response. Methods and Results Isolated ejecting guinea pig hearts (constant afterload and heart rate) were studied before and after interventions. Elevation of filling pressure from 10 to 20 cm H 2 O increased cardiac output, LV end-diastolic pressure (LVEDP), and peak LV pressure (LVP max ). In the presence of N G -monomethyl- l -arginine (L-NMMA, 10 μmol/L; n=10) or free hemoglobin (1 μmol/L; n=8), preload-induced increases in cardiac output were significantly attenuated but baseline cardiac output was unaffected. The effects of L-NMMA were inhibited in the presence of excess l -arginine (100 μmol/L; n=6). These changes were not attributable to alterations in coronary flow. Prostaglandin F 2α (0.01 μmol/L; n=6), which reduced coronary flow, failed to alter the cardiac output response to preload elevation. The exogenous nitric oxide donor sodium nitroprusside (1 μmol/L; n=6) reduced cardiac output at the lowest preload but not at higher preloads. LVEDP was elevated after L-NMMA and hemoglobin but reduced after sodium nitroprusside. Conclusions Basal intracardiac production of nitric oxide significantly augments preload-induced rises in cardiac output in the isolated ejecting guinea pig heart. The mechanism appears to be unrelated to changes in coronary flow and may involve direct effects of nitric oxide on myocardial diastolic and/or systolic function." @default.
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• W2007472328 date "1997-08-19" @default.
• W2007472328 modified "2023-09-24" @default.
• W2007472328 title "Basal Release of Nitric Oxide Augments the Frank-Starling Response in the Isolated Heart" @default.
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• W2007472328 doi "https://doi.org/10.1161/01.cir.96.4.1320" @default.
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