FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007472940> ?p ?o ?g. }

• W2007472940 endingPage "449" @default.
• W2007472940 startingPage "442" @default.
• W2007472940 abstract "Increasing evidence suggests that adenosine and ATP not only modulate cell growth and differentiation, but may also act as inducers of cell death. In the session “Purines and cell death,” held during the Purines '96 Symposium and chaired by Claudio Franceschi (Modena, Italy) and Geoffrey Burnstock (London, UK) presentation and discussion of new studies on the modulation of cell death by adenosine and ATP raised novel implications for a possible role of purines in both development and in the pathophysiology of various diseases. The cloning of a new ligand-gated P2X receptor (the P2X7) was reported, and pharmacological studies have demonstrated that this is the unique P2Z receptor known to cause cell death by cytolysis. During the session, induction of apoptosis by ATP was reported in a murine macrophage cell line (confirming a role for ATP in inflammation and immunomodulation), in cultures of renal mesangial cells and of endothelial cells from bovine main pulmonary artery; furthermore, ATP was shown to modulate glutamate neurotoxicity in cerebellar granule cells, suggesting that apoptosis by ATP is not only restricted to cells of the immune lineage, but may represent a more general means to regulate cell survival. Adenosine and its derivatives have been known for years to induce apoptosis of human lymphoid tissues, but it has been demonstrated only recently that these effects can also occur in other cell types, and that they can be due either to the activation of extracellular adenosine receptors or to an intracellular mechanism of action. During the session “Purines and cell death,” various authors reported apoptosis by adenosine analogues in human peripheral blood mononuclear cells, but also in chick sympathetic neurons, rat chromaffin cells, rat cerebellar granule neurons, intact chick embryos and rat microglial cells, suggesting that adenosine may play an important role not only in modulation of survival of lymphoid cells but also in the development and remodelling of the nervous system. A dual role for the adenosine A3 receptor in cell survival was also demonstrated in cells of the astroglial lineage, as shown by induction of apoptosis at high concentrations of A3 receptor agonists and protection from spontaneous cell death at low concentrations, suggesting that this receptor may promote either cell death or survival likely depending on the metabolic and functional state of the tissue. It was also reported that, following an ischemic episode, an alterated metabolism of adenine nucleotides and nucleosides in the heart may be the basis of the lack of recovery of phosphorylated forms of adenosine due to oxidative stress, therefore contributing to heart damage. Taken together, all these data confirm the involvement of purines in modulation of cell survival in various organs and systems; moreover, based on these data, it is expected that the characterization of the specific purinoceptor subtypes involved in these actions may lead to the development of entirely new therapeutic approaches to several diseases. Drug Dev. Res. 39:442–449, 1996. © 1997 Wiley-Liss, Inc." @default.
• W2007472940 created "2016-06-24" @default.
• W2007472940 creator A5003933043 @default.
• W2007472940 creator A5009219737 @default.
• W2007472940 creator A5016722941 @default.
• W2007472940 creator A5026093337 @default.
• W2007472940 creator A5029033280 @default.
• W2007472940 creator A5039913930 @default.
• W2007472940 creator A5042264523 @default.
• W2007472940 creator A5051019086 @default.
• W2007472940 creator A5052093274 @default.
• W2007472940 creator A5058369958 @default.
• W2007472940 creator A5058480540 @default.
• W2007472940 creator A5062628094 @default.
• W2007472940 creator A5078302741 @default.
• W2007472940 creator A5083419407 @default.
• W2007472940 date "1996-11-01" @default.
• W2007472940 modified "2023-09-26" @default.
• W2007472940 title "Purines and cell death" @default.
• W2007472940 cites W1505072477 @default.
• W2007472940 cites W1579992296 @default.
• W2007472940 cites W1608870321 @default.
• W2007472940 cites W1863559933 @default.
• W2007472940 cites W1868766358 @default.
• W2007472940 cites W1965206680 @default.
• W2007472940 cites W1972440163 @default.
• W2007472940 cites W1974415685 @default.
• W2007472940 cites W1975532531 @default.
• W2007472940 cites W1977499961 @default.
• W2007472940 cites W1980281595 @default.
• W2007472940 cites W1992484302 @default.
• W2007472940 cites W1992881221 @default.
• W2007472940 cites W1999515465 @default.
• W2007472940 cites W2013795726 @default.
• W2007472940 cites W2017065079 @default.
• W2007472940 cites W2020316909 @default.
• W2007472940 cites W2029155906 @default.
• W2007472940 cites W2044041384 @default.
• W2007472940 cites W2051070266 @default.
• W2007472940 cites W2065009203 @default.
• W2007472940 cites W2066784771 @default.
• W2007472940 cites W2071025232 @default.
• W2007472940 cites W2076632777 @default.
• W2007472940 cites W2078297328 @default.
• W2007472940 cites W2084609653 @default.
• W2007472940 cites W2150064227 @default.
• W2007472940 cites W2163518147 @default.
• W2007472940 cites W4233161682 @default.
• W2007472940 cites W4240037281 @default.
• W2007472940 doi "https://doi.org/10.1002/(sici)1098-2299(199611/12)39:3/4<442::aid-ddr26>3.0.co;2-1" @default.
• W2007472940 hasPublicationYear "1996" @default.
• W2007472940 type Work @default.
• W2007472940 sameAs 2007472940 @default.
• W2007472940 citedByCount "31" @default.
• W2007472940 countsByYear W20074729402014 @default.
• W2007472940 crossrefType "journal-article" @default.
• W2007472940 hasAuthorship W2007472940A5003933043 @default.
• W2007472940 hasAuthorship W2007472940A5009219737 @default.
• W2007472940 hasAuthorship W2007472940A5016722941 @default.
• W2007472940 hasAuthorship W2007472940A5026093337 @default.
• W2007472940 hasAuthorship W2007472940A5029033280 @default.
• W2007472940 hasAuthorship W2007472940A5039913930 @default.
• W2007472940 hasAuthorship W2007472940A5042264523 @default.
• W2007472940 hasAuthorship W2007472940A5051019086 @default.
• W2007472940 hasAuthorship W2007472940A5052093274 @default.
• W2007472940 hasAuthorship W2007472940A5058369958 @default.
• W2007472940 hasAuthorship W2007472940A5058480540 @default.
• W2007472940 hasAuthorship W2007472940A5062628094 @default.
• W2007472940 hasAuthorship W2007472940A5078302741 @default.
• W2007472940 hasAuthorship W2007472940A5083419407 @default.
• W2007472940 hasConcept C16587737 @default.
• W2007472940 hasConcept C169586020 @default.
• W2007472940 hasConcept C170493617 @default.
• W2007472940 hasConcept C172590197 @default.
• W2007472940 hasConcept C181199279 @default.
• W2007472940 hasConcept C190283241 @default.
• W2007472940 hasConcept C2776991684 @default.
• W2007472940 hasConcept C2778938600 @default.
• W2007472940 hasConcept C2780876210 @default.
• W2007472940 hasConcept C28406088 @default.
• W2007472940 hasConcept C31573885 @default.
• W2007472940 hasConcept C34628245 @default.
• W2007472940 hasConcept C55493867 @default.
• W2007472940 hasConcept C67907053 @default.
• W2007472940 hasConcept C86803240 @default.
• W2007472940 hasConcept C94030615 @default.
• W2007472940 hasConcept C95444343 @default.
• W2007472940 hasConceptScore W2007472940C16587737 @default.
• W2007472940 hasConceptScore W2007472940C169586020 @default.
• W2007472940 hasConceptScore W2007472940C170493617 @default.
• W2007472940 hasConceptScore W2007472940C172590197 @default.
• W2007472940 hasConceptScore W2007472940C181199279 @default.
• W2007472940 hasConceptScore W2007472940C190283241 @default.
• W2007472940 hasConceptScore W2007472940C2776991684 @default.
• W2007472940 hasConceptScore W2007472940C2778938600 @default.
• W2007472940 hasConceptScore W2007472940C2780876210 @default.
• W2007472940 hasConceptScore W2007472940C28406088 @default.
• W2007472940 hasConceptScore W2007472940C31573885 @default.

• next