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• W2007477611 abstract "The glmS-riboswitch is unique among riboswitch families as it represents a metabolite-dependent ribozyme that undergoes self-cleavage upon recognition of glucosamin-6-phosphate. The glmS-riboswitch is located in the 5'-untranslated region of bacterial genes involved in cell wall biosynthesis. Therefore, this riboswitch represents a promising target for developing new antibiotics. We describe the metabolite-dependent glmS-riboswitch of pathologically relevant and vancomycin-resistant Staphylococcus aureus and the discovery and synthesis of a carba-sugar with potency similar to that of the native metabolite glucosamine-6-phosphate in modulating riboswitch activity. This compound represents a valuable lead structure for the development of antibiotics with a novel mode of action." @default.
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• W2007477611 date "2011-04-20" @default.
• W2007477611 modified "2023-10-10" @default.
• W2007477611 title "Carba-sugars Activate the glmS-Riboswitch of <i>Staphylococcus aureus</i>" @default.
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• W2007477611 doi "https://doi.org/10.1021/cb200016d" @default.
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