Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007479516> ?p ?o ?g. }
- W2007479516 abstract "Cytoplasmic dynein play an important role in transporting various intracellular cargos by coupling their ATP hydrolysis cycle with their conformational changes. Recent experimental results showed that the cytoplasmic dynein had a highly variable stepping pattern including hand-over-hand, inchworm and nonalternating-inchworm. Here, we developed a model to describe the coordinated stepping patterns of cytoplasmic dynein, based on its working cycle, construction and the interaction between its leading head and tailing head. The kinetic model showed how change in the distance between the two heads influences the rate of cytoplasmic dynein under different stepping patterns. Numerical simulations of the distribution of step size and striding rate are in good quantitative agreement with experimental observations. Hence, our coordinated stepping model for cytoplasmic dynein successfully explained its diverse stepping patterns as a molecular motor. The cooperative mechanism carried out by the two heads of cytoplasmic dynein shed light on the strategies adopted by the cytoplasmic dynein in executing various functions." @default.
- W2007479516 created "2016-06-24" @default.
- W2007479516 creator A5011028490 @default.
- W2007479516 creator A5025866403 @default.
- W2007479516 creator A5040954728 @default.
- W2007479516 creator A5043329970 @default.
- W2007479516 creator A5085786965 @default.
- W2007479516 date "2014-10-01" @default.
- W2007479516 modified "2023-09-26" @default.
- W2007479516 title "A model for the coordinated stepping of cytoplasmic dynein" @default.
- W2007479516 cites W1580743148 @default.
- W2007479516 cites W1875835053 @default.
- W2007479516 cites W1964521479 @default.
- W2007479516 cites W1965539063 @default.
- W2007479516 cites W1971721247 @default.
- W2007479516 cites W1978309689 @default.
- W2007479516 cites W1980123238 @default.
- W2007479516 cites W2010366657 @default.
- W2007479516 cites W2018709028 @default.
- W2007479516 cites W2020234447 @default.
- W2007479516 cites W2041050031 @default.
- W2007479516 cites W2052937897 @default.
- W2007479516 cites W2053376533 @default.
- W2007479516 cites W2070499037 @default.
- W2007479516 cites W2072278366 @default.
- W2007479516 cites W2073752458 @default.
- W2007479516 cites W2079984410 @default.
- W2007479516 cites W2094760360 @default.
- W2007479516 cites W2110641277 @default.
- W2007479516 cites W2112404016 @default.
- W2007479516 cites W2117114738 @default.
- W2007479516 cites W2121431496 @default.
- W2007479516 cites W2126194553 @default.
- W2007479516 cites W2131112743 @default.
- W2007479516 cites W2137065909 @default.
- W2007479516 cites W2142726051 @default.
- W2007479516 cites W2144938845 @default.
- W2007479516 cites W2148156421 @default.
- W2007479516 cites W2153138268 @default.
- W2007479516 cites W2157979678 @default.
- W2007479516 cites W2165237971 @default.
- W2007479516 doi "https://doi.org/10.1016/j.bbrc.2014.09.138" @default.
- W2007479516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25301561" @default.
- W2007479516 hasPublicationYear "2014" @default.
- W2007479516 type Work @default.
- W2007479516 sameAs 2007479516 @default.
- W2007479516 citedByCount "3" @default.
- W2007479516 countsByYear W20074795162016 @default.
- W2007479516 countsByYear W20074795162018 @default.
- W2007479516 countsByYear W20074795162019 @default.
- W2007479516 crossrefType "journal-article" @default.
- W2007479516 hasAuthorship W2007479516A5011028490 @default.
- W2007479516 hasAuthorship W2007479516A5025866403 @default.
- W2007479516 hasAuthorship W2007479516A5040954728 @default.
- W2007479516 hasAuthorship W2007479516A5043329970 @default.
- W2007479516 hasAuthorship W2007479516A5085786965 @default.
- W2007479516 hasConcept C106987784 @default.
- W2007479516 hasConcept C12554922 @default.
- W2007479516 hasConcept C141315368 @default.
- W2007479516 hasConcept C160408235 @default.
- W2007479516 hasConcept C181199279 @default.
- W2007479516 hasConcept C185592680 @default.
- W2007479516 hasConcept C190062978 @default.
- W2007479516 hasConcept C20418707 @default.
- W2007479516 hasConcept C23265538 @default.
- W2007479516 hasConcept C55493867 @default.
- W2007479516 hasConcept C86803240 @default.
- W2007479516 hasConcept C95444343 @default.
- W2007479516 hasConceptScore W2007479516C106987784 @default.
- W2007479516 hasConceptScore W2007479516C12554922 @default.
- W2007479516 hasConceptScore W2007479516C141315368 @default.
- W2007479516 hasConceptScore W2007479516C160408235 @default.
- W2007479516 hasConceptScore W2007479516C181199279 @default.
- W2007479516 hasConceptScore W2007479516C185592680 @default.
- W2007479516 hasConceptScore W2007479516C190062978 @default.
- W2007479516 hasConceptScore W2007479516C20418707 @default.
- W2007479516 hasConceptScore W2007479516C23265538 @default.
- W2007479516 hasConceptScore W2007479516C55493867 @default.
- W2007479516 hasConceptScore W2007479516C86803240 @default.
- W2007479516 hasConceptScore W2007479516C95444343 @default.
- W2007479516 hasFunder F4320321001 @default.
- W2007479516 hasLocation W20074795161 @default.
- W2007479516 hasLocation W20074795162 @default.
- W2007479516 hasOpenAccess W2007479516 @default.
- W2007479516 hasPrimaryLocation W20074795161 @default.
- W2007479516 hasRelatedWork W1967601959 @default.
- W2007479516 hasRelatedWork W2002444209 @default.
- W2007479516 hasRelatedWork W2041834109 @default.
- W2007479516 hasRelatedWork W2053376533 @default.
- W2007479516 hasRelatedWork W2056058756 @default.
- W2007479516 hasRelatedWork W2064308697 @default.
- W2007479516 hasRelatedWork W2064451912 @default.
- W2007479516 hasRelatedWork W2066953920 @default.
- W2007479516 hasRelatedWork W2084729729 @default.
- W2007479516 hasRelatedWork W2089947227 @default.
- W2007479516 hasRelatedWork W2153138268 @default.
- W2007479516 hasRelatedWork W2167220490 @default.
- W2007479516 hasRelatedWork W2341143253 @default.
- W2007479516 hasRelatedWork W2517060216 @default.
- W2007479516 hasRelatedWork W2895639691 @default.