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- W2007481878 abstract "Kinetics of the hydrolysis of a P1-(7-methylguanosinyl-5′) P3-(guanosinyl-5′) triphosphate (m7GpppG), P1-(7-methylguanosinyl-5′) P4- (guanosinyl-5′) tetraphosphate (m7GppppG), diadenosine-5′,5‴-P1,P3-triphosphate (ApppA), and diadenosine-5′,5‴-P1,P4-tetraphosphate (AppppA) promoted by Cu2+ or Zn2+ has been investigated. Time-dependent products distributions at various metal ion concentrations have been determined by CZE and HPLC-RP. The results show that in acidic conditions, in the presence of metal ion, the predominant hydrolytic reaction is the cleavage of 5′,5′-oligophosphate bridge. The 5′,5′-oligophosphate bridge of the dinucleotides studied is hydrolyzed by Cu2+ more efficiently than by Zn2+. At the catalyst concentration of 2 mM the cleavage of the 5′,5′-triphosphate bridge of m7GpppG was ∼3.6 times faster, and that of the tetraphosphate bridge of m7GppppG ∼2.3-fold faster in the presence of Cu2+ compared to the Zn2+ ion, applied as catalysts. Dependence of the rates of hydrolysis on the catalyst concentration was in some instances not linear, interpreted as evidence for participation of more than one metal ion in the transition complex." @default.
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- W2007481878 date "2011-03-01" @default.
- W2007481878 modified "2023-09-27" @default.
- W2007481878 title "Hydrolysis of 5′,5′-Tri- or Tetraphosphate-mRNA 5′-cap Analogs Promoted by Cu2+or Zn2+Metal Ions" @default.
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- W2007481878 doi "https://doi.org/10.1080/15257770.2010.551722" @default.
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