FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007486148> ?p ?o ?g. }

• W2007486148 endingPage "1191" @default.
• W2007486148 startingPage "1179" @default.
• W2007486148 abstract "Abstract The metastatic breast cancer cell line, 4T1, abundantly expresses the oligosaccharide sialylated Lewis x (sLe x ). SLe x oligosaccharide on tumor cells can be recognized by E‐ and P‐selectin, contributing to tumor metastatic process. We observed that both selectins reacted with this cell line. However, contrary to the E‐selectin reactivity, which was sLe x dependent, P‐selectin reactivity with this cell line was sLe x ‐independent. The sLe x ‐Neg variant of the 4T1 cell line with markedly diminished expression of sLe x and lack of sLe a , provided a unique opportunity to characterize P‐selectin ligands and their contribution to metastasis in the absence of overlapping selectin ligands and E‐selectin binding. We observed that P‐selectin binding was Ca 2+ ‐independent and sulfation‐dependent. We found that P‐selectin reacted primarily with cell surface chondroitin sulfate (CS) proteoglycans, which were abundantly and stably expressed on the surface of the 4T1 cell line. P‐selectin binding to the 4T1 cells was inhibited by heparin and CS glycosaminoglycans (GAGs). Moreover, Heparin administration significantly inhibited experimental lung metastasis. In addition, the data suggest that surface CS GAG chains were involved in P‐selectin mediated adhesion of the 4T1 cells to murine platelets and human umbilical vein endothelial cells. The data suggest that CS GAGs are also the major P‐selectin‐reactive ligands on the surface of human MDA‐MET cells. The results warrant conducting clinical studies on the involvement of cell surface CS chains in breast cancer metastasis and evaluation of various CS types and their biosynthetic pathways as target for development of treatment strategies for antimetastatic therapy of this disease. © 2006 Wiley‐Liss, Inc." @default.
• W2007486148 created "2016-06-24" @default.
• W2007486148 creator A5013397406 @default.
• W2007486148 creator A5019401451 @default.
• W2007486148 creator A5022585391 @default.
• W2007486148 creator A5054747456 @default.
• W2007486148 creator A5062045565 @default.
• W2007486148 creator A5070854164 @default.
• W2007486148 creator A5091865132 @default.
• W2007486148 date "2006-12-07" @default.
• W2007486148 modified "2023-10-17" @default.
• W2007486148 title "Chondroitin sulfate glycosaminoglycans as major P-selectin ligands on metastatic breast cancer cell lines" @default.
• W2007486148 cites W1479974475 @default.
• W2007486148 cites W1520425169 @default.
• W2007486148 cites W1548017735 @default.
• W2007486148 cites W1549044728 @default.
• W2007486148 cites W1549953248 @default.
• W2007486148 cites W1595099528 @default.
• W2007486148 cites W1622358858 @default.
• W2007486148 cites W1853590226 @default.
• W2007486148 cites W1965255713 @default.
• W2007486148 cites W1966126000 @default.
• W2007486148 cites W1977696308 @default.
• W2007486148 cites W2001475156 @default.
• W2007486148 cites W2002512371 @default.
• W2007486148 cites W2006450996 @default.
• W2007486148 cites W2006641366 @default.
• W2007486148 cites W2014678714 @default.
• W2007486148 cites W2015581428 @default.
• W2007486148 cites W2017704712 @default.
• W2007486148 cites W2031293233 @default.
• W2007486148 cites W2046778136 @default.
• W2007486148 cites W2047216324 @default.
• W2007486148 cites W2052312474 @default.
• W2007486148 cites W2055810432 @default.
• W2007486148 cites W2055942941 @default.
• W2007486148 cites W2060529002 @default.
• W2007486148 cites W2063571042 @default.
• W2007486148 cites W2063645267 @default.
• W2007486148 cites W2065691028 @default.
• W2007486148 cites W2074736160 @default.
• W2007486148 cites W2076788883 @default.
• W2007486148 cites W2089394059 @default.
• W2007486148 cites W2091913466 @default.
• W2007486148 cites W2093036222 @default.
• W2007486148 cites W2094695196 @default.
• W2007486148 cites W2096029533 @default.
• W2007486148 cites W2118754499 @default.
• W2007486148 cites W2124555370 @default.
• W2007486148 cites W2131245262 @default.
• W2007486148 cites W2138368121 @default.
• W2007486148 cites W2140074915 @default.
• W2007486148 cites W2140336796 @default.
• W2007486148 cites W2144169464 @default.
• W2007486148 cites W2153125007 @default.
• W2007486148 cites W2162390651 @default.
• W2007486148 cites W2170200613 @default.
• W2007486148 cites W4240092220 @default.
• W2007486148 cites W4299883346 @default.
• W2007486148 doi "https://doi.org/10.1002/ijc.22424" @default.
• W2007486148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17154173" @default.
• W2007486148 hasPublicationYear "2006" @default.
• W2007486148 type Work @default.
• W2007486148 sameAs 2007486148 @default.
• W2007486148 citedByCount "78" @default.
• W2007486148 countsByYear W20074861482012 @default.
• W2007486148 countsByYear W20074861482013 @default.
• W2007486148 countsByYear W20074861482014 @default.
• W2007486148 countsByYear W20074861482015 @default.
• W2007486148 countsByYear W20074861482016 @default.
• W2007486148 countsByYear W20074861482017 @default.
• W2007486148 countsByYear W20074861482018 @default.
• W2007486148 countsByYear W20074861482019 @default.
• W2007486148 countsByYear W20074861482020 @default.
• W2007486148 countsByYear W20074861482021 @default.
• W2007486148 countsByYear W20074861482022 @default.
• W2007486148 countsByYear W20074861482023 @default.
• W2007486148 crossrefType "journal-article" @default.
• W2007486148 hasAuthorship W2007486148A5013397406 @default.
• W2007486148 hasAuthorship W2007486148A5019401451 @default.
• W2007486148 hasAuthorship W2007486148A5022585391 @default.
• W2007486148 hasAuthorship W2007486148A5054747456 @default.
• W2007486148 hasAuthorship W2007486148A5062045565 @default.
• W2007486148 hasAuthorship W2007486148A5070854164 @default.
• W2007486148 hasAuthorship W2007486148A5091865132 @default.
• W2007486148 hasConcept C121608353 @default.
• W2007486148 hasConcept C126322002 @default.
• W2007486148 hasConcept C1491633281 @default.
• W2007486148 hasConcept C153074725 @default.
• W2007486148 hasConcept C153911025 @default.
• W2007486148 hasConcept C155619193 @default.
• W2007486148 hasConcept C16224149 @default.
• W2007486148 hasConcept C185592680 @default.
• W2007486148 hasConcept C202751555 @default.
• W2007486148 hasConcept C203014093 @default.
• W2007486148 hasConcept C2775930923 @default.
• W2007486148 hasConcept C2777117008 @default.
• W2007486148 hasConcept C2777411675 @default.

• next