FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007487275> ?p ?o ?g. }

• W2007487275 endingPage "88" @default.
• W2007487275 startingPage "83" @default.
• W2007487275 abstract "Vasotab TY is a KGD (Lys-Gly-Asp)-containing peptide identified from salivary glands of the horsefly of Tabanus yao. We have previously reported that vasotab TY showed a strong vasodilator activity. In the present study, vasotab TY was found to inhibit platelet aggregation effectively. It completely inhibited platelet aggregation induced by adenosine diphosphate (ADP) at the concentration of 9.6 μg/ml. Vasotab TY significantly reduced thrombus weight in rat arteriovenous shunt model and inhibited thrombosis in carrageenan-induced mouse tail thrombosis model in vivo. Vasotab TY competitively bound to glycoprotein IIb/IIIa (GPIIb/IIIa) with eptifibatide, a well-known KGD-containing cyclic heptapeptide containing high specificity and high affinity for GPIIb/IIIa, suggesting that it is an antagonist of the fibrinogen receptor GPIIb/IIIa on the surface of platelet. The KGD motif in vasotab TY may facilitate the binding of it to GPIIb/IIIa. Vasotab TY showed a half-life of more than 1 h in vivo. It showed little side effects including little bleeding, no hemolytic activity on human blood red cells and no cytotoxicity on human keratinocyte and THP-1 cells. Combined its vasodilator and platelet inhibitory functions, vasotab TY might be an excellent candidate for the development of clinical anti-thrombosis medicines." @default.
• W2007487275 created "2016-06-24" @default.
• W2007487275 creator A5004110391 @default.
• W2007487275 creator A5010238428 @default.
• W2007487275 creator A5020670756 @default.
• W2007487275 creator A5050716657 @default.
• W2007487275 creator A5071342749 @default.
• W2007487275 creator A5073600439 @default.
• W2007487275 date "2014-09-01" @default.
• W2007487275 modified "2023-10-18" @default.
• W2007487275 title "A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands" @default.
• W2007487275 cites W11448426 @default.
• W2007487275 cites W1531044414 @default.
• W2007487275 cites W1579308444 @default.
• W2007487275 cites W1945854413 @default.
• W2007487275 cites W1983169511 @default.
• W2007487275 cites W2002107909 @default.
• W2007487275 cites W2004177921 @default.
• W2007487275 cites W2018546230 @default.
• W2007487275 cites W2024074014 @default.
• W2007487275 cites W2030437369 @default.
• W2007487275 cites W2031311872 @default.
• W2007487275 cites W2034776066 @default.
• W2007487275 cites W2050744333 @default.
• W2007487275 cites W2053025020 @default.
• W2007487275 cites W2057116025 @default.
• W2007487275 cites W2067116007 @default.
• W2007487275 cites W2068534992 @default.
• W2007487275 cites W2072889522 @default.
• W2007487275 cites W2074631110 @default.
• W2007487275 cites W2074726679 @default.
• W2007487275 cites W2096213888 @default.
• W2007487275 cites W2103933130 @default.
• W2007487275 cites W2108713158 @default.
• W2007487275 cites W2111371750 @default.
• W2007487275 cites W2118462346 @default.
• W2007487275 cites W2137788779 @default.
• W2007487275 cites W2140221190 @default.
• W2007487275 cites W2149954428 @default.
• W2007487275 cites W2150319500 @default.
• W2007487275 cites W2152150730 @default.
• W2007487275 cites W2152174597 @default.
• W2007487275 cites W2152389498 @default.
• W2007487275 cites W2156161328 @default.
• W2007487275 cites W2327269495 @default.
• W2007487275 cites W2409284362 @default.
• W2007487275 doi "https://doi.org/10.1016/j.biocel.2014.07.004" @default.
• W2007487275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25025626" @default.
• W2007487275 hasPublicationYear "2014" @default.
• W2007487275 type Work @default.
• W2007487275 sameAs 2007487275 @default.
• W2007487275 citedByCount "16" @default.
• W2007487275 countsByYear W20074872752015 @default.
• W2007487275 countsByYear W20074872752016 @default.
• W2007487275 countsByYear W20074872752017 @default.
• W2007487275 countsByYear W20074872752018 @default.
• W2007487275 countsByYear W20074872752020 @default.
• W2007487275 countsByYear W20074872752022 @default.
• W2007487275 countsByYear W20074872752023 @default.
• W2007487275 crossrefType "journal-article" @default.
• W2007487275 hasAuthorship W2007487275A5004110391 @default.
• W2007487275 hasAuthorship W2007487275A5010238428 @default.
• W2007487275 hasAuthorship W2007487275A5020670756 @default.
• W2007487275 hasAuthorship W2007487275A5050716657 @default.
• W2007487275 hasAuthorship W2007487275A5071342749 @default.
• W2007487275 hasAuthorship W2007487275A5073600439 @default.
• W2007487275 hasConcept C150903083 @default.
• W2007487275 hasConcept C185592680 @default.
• W2007487275 hasConcept C202751555 @default.
• W2007487275 hasConcept C203014093 @default.
• W2007487275 hasConcept C207001950 @default.
• W2007487275 hasConcept C26291073 @default.
• W2007487275 hasConcept C3018697912 @default.
• W2007487275 hasConcept C55493867 @default.
• W2007487275 hasConcept C71924100 @default.
• W2007487275 hasConcept C86803240 @default.
• W2007487275 hasConcept C89560881 @default.
• W2007487275 hasConcept C98274493 @default.
• W2007487275 hasConceptScore W2007487275C150903083 @default.
• W2007487275 hasConceptScore W2007487275C185592680 @default.
• W2007487275 hasConceptScore W2007487275C202751555 @default.
• W2007487275 hasConceptScore W2007487275C203014093 @default.
• W2007487275 hasConceptScore W2007487275C207001950 @default.
• W2007487275 hasConceptScore W2007487275C26291073 @default.
• W2007487275 hasConceptScore W2007487275C3018697912 @default.
• W2007487275 hasConceptScore W2007487275C55493867 @default.
• W2007487275 hasConceptScore W2007487275C71924100 @default.
• W2007487275 hasConceptScore W2007487275C86803240 @default.
• W2007487275 hasConceptScore W2007487275C89560881 @default.
• W2007487275 hasConceptScore W2007487275C98274493 @default.
• W2007487275 hasFunder F4320321001 @default.
• W2007487275 hasFunder F4320321133 @default.
• W2007487275 hasFunder F4320321605 @default.
• W2007487275 hasFunder F4320322108 @default.
• W2007487275 hasLocation W20074872751 @default.
• W2007487275 hasLocation W20074872752 @default.
• W2007487275 hasOpenAccess W2007487275 @default.
• W2007487275 hasPrimaryLocation W20074872751 @default.

• next