FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007488172> ?p ?o ?g. }

• W2007488172 endingPage "3035" @default.
• W2007488172 startingPage "3029" @default.
• W2007488172 abstract "In the reaction cycle of P-type ATPases, an acid-stable phosphorylated intermediate is formed which is present in an intracellularly located domain of the membrane-bound enzymes. In some of these ATPases, such as Na+,K+-ATPase and gastric H+, K+-ATPase, extracellular K+ ions stimulate the rate of dephosphorylation of this phosphorylated intermediate and so stimulate the ATPase activity. The mechanism by which extracellular K+ ions stimulate the dephosphorylation process is unresolved. Here we show that three mutants of gastric H+,K+-ATPase lacking a negative charge on residue 820, located in transmembrane segment six of the alpha-subunit, have a high SCH 28080-sensitive, but K+-insensitive ATPase activity. This high activity is caused by an increased 'spontaneous' rate of dephosphorylation of the phosphorylated intermediate. A mutant with an aspartic acid instead of a glutamic acid residue in position 820 showed hardly any ATPase activity in the absence of K+, but K+ ions stimulated ATPase activity and the dephosphorylation process. These findings indicate that the negative charge normally present on residue 820 inhibits the dephosphorylation process. K+ ions do not stimulate dephosphorylation of the phosphorylated intermediate directly, but act by neutralizing the inhibitory effect of a negative charge in the membrane." @default.
• W2007488172 created "2016-06-24" @default.
• W2007488172 creator A5039644025 @default.
• W2007488172 creator A5044877917 @default.
• W2007488172 creator A5070010039 @default.
• W2007488172 creator A5085209788 @default.
• W2007488172 creator A5088469603 @default.
• W2007488172 date "1998-06-01" @default.
• W2007488172 modified "2023-09-26" @default.
• W2007488172 title "Constitutive activation of gastric H+,K+-ATPase by a single mutation" @default.
• W2007488172 cites W1516172894 @default.
• W2007488172 cites W1536271035 @default.
• W2007488172 cites W1548022389 @default.
• W2007488172 cites W1563487756 @default.
• W2007488172 cites W1573664132 @default.
• W2007488172 cites W1578508637 @default.
• W2007488172 cites W1579824808 @default.
• W2007488172 cites W1596185709 @default.
• W2007488172 cites W1605676393 @default.
• W2007488172 cites W1606519767 @default.
• W2007488172 cites W1608544771 @default.
• W2007488172 cites W1975645575 @default.
• W2007488172 cites W1983979369 @default.
• W2007488172 cites W1988571268 @default.
• W2007488172 cites W2000546733 @default.
• W2007488172 cites W2006659213 @default.
• W2007488172 cites W2007979534 @default.
• W2007488172 cites W2008962068 @default.
• W2007488172 cites W2010091380 @default.
• W2007488172 cites W2015493792 @default.
• W2007488172 cites W2018751263 @default.
• W2007488172 cites W2036873028 @default.
• W2007488172 cites W2040198458 @default.
• W2007488172 cites W2045156089 @default.
• W2007488172 cites W2059394443 @default.
• W2007488172 cites W2060229450 @default.
• W2007488172 cites W2064036102 @default.
• W2007488172 cites W2064360694 @default.
• W2007488172 cites W2076691657 @default.
• W2007488172 cites W2077613046 @default.
• W2007488172 cites W2079313039 @default.
• W2007488172 cites W2081226748 @default.
• W2007488172 cites W2087726424 @default.
• W2007488172 cites W2088999850 @default.
• W2007488172 cites W2094493206 @default.
• W2007488172 cites W2097432039 @default.
• W2007488172 cites W2146496955 @default.
• W2007488172 cites W2204509125 @default.
• W2007488172 cites W2288635056 @default.
• W2007488172 cites W2345085744 @default.
• W2007488172 doi "https://doi.org/10.1093/emboj/17.11.3029" @default.
• W2007488172 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1170642" @default.
• W2007488172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9606185" @default.
• W2007488172 hasPublicationYear "1998" @default.
• W2007488172 type Work @default.
• W2007488172 sameAs 2007488172 @default.
• W2007488172 citedByCount "32" @default.
• W2007488172 countsByYear W20074881722012 @default.
• W2007488172 countsByYear W20074881722015 @default.
• W2007488172 countsByYear W20074881722016 @default.
• W2007488172 countsByYear W20074881722018 @default.
• W2007488172 crossrefType "journal-article" @default.
• W2007488172 hasAuthorship W2007488172A5039644025 @default.
• W2007488172 hasAuthorship W2007488172A5044877917 @default.
• W2007488172 hasAuthorship W2007488172A5070010039 @default.
• W2007488172 hasAuthorship W2007488172A5085209788 @default.
• W2007488172 hasAuthorship W2007488172A5088469603 @default.
• W2007488172 hasBestOaLocation W20074881722 @default.
• W2007488172 hasConcept C104317684 @default.
• W2007488172 hasConcept C11960822 @default.
• W2007488172 hasConcept C12554922 @default.
• W2007488172 hasConcept C143065580 @default.
• W2007488172 hasConcept C178666793 @default.
• W2007488172 hasConcept C181199279 @default.
• W2007488172 hasConcept C181912034 @default.
• W2007488172 hasConcept C23265538 @default.
• W2007488172 hasConcept C28406088 @default.
• W2007488172 hasConcept C2911069308 @default.
• W2007488172 hasConcept C55493867 @default.
• W2007488172 hasConcept C86803240 @default.
• W2007488172 hasConceptScore W2007488172C104317684 @default.
• W2007488172 hasConceptScore W2007488172C11960822 @default.
• W2007488172 hasConceptScore W2007488172C12554922 @default.
• W2007488172 hasConceptScore W2007488172C143065580 @default.
• W2007488172 hasConceptScore W2007488172C178666793 @default.
• W2007488172 hasConceptScore W2007488172C181199279 @default.
• W2007488172 hasConceptScore W2007488172C181912034 @default.
• W2007488172 hasConceptScore W2007488172C23265538 @default.
• W2007488172 hasConceptScore W2007488172C28406088 @default.
• W2007488172 hasConceptScore W2007488172C2911069308 @default.
• W2007488172 hasConceptScore W2007488172C55493867 @default.
• W2007488172 hasConceptScore W2007488172C86803240 @default.
• W2007488172 hasIssue "11" @default.
• W2007488172 hasLocation W20074881721 @default.
• W2007488172 hasLocation W20074881722 @default.
• W2007488172 hasLocation W20074881723 @default.
• W2007488172 hasLocation W20074881724 @default.
• W2007488172 hasOpenAccess W2007488172 @default.

• next