FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007489114> ?p ?o ?g. }

• W2007489114 endingPage "594" @default.
• W2007489114 startingPage "579" @default.
• W2007489114 abstract "The role of neuropeptides and the significance of peptidergic mechanisms in neurodegenerative diseases are still unclear. In the periphery, nerve injury results in dramatic changes in the expression of neuropeptides. An important question regards to what extent similar changes occur, and similar mechanisms operate, after lesions and/or degeneration in the brain. The purpose of this work is, therefore, to study neuropeptides with regard to their presence and distribution in the APP23 mouse (HuAPP(751) K670M/N671L under the murine Thy-1 promoter), a model for Alzheimer's disease, or cerebral amyloidosis, using the immunohistochemical technique. In addition, tyrosine hydroxylase and acetylcholinesterase were analyzed. This study shows marked neuropeptide changes in the hippocampal formation and the ventral cortex, whereas the dorsolateral neocortex was less affected. There was a considerable variation with regard to peptide expression among animals of the same age which was related to the variation in Abeta deposition. Dystrophic and varicose fibers containing galanin, neuropeptide Y, enkephalin, and especially cholecystokinin were commonly seen in close proximity to amyloid plaques. In addition, generalized changes were observed, such as increases of enkephalin and neuropeptide Y in stratum lacunosum moleculare and of neuropeptide Y, enkephalin, and dynorphin in mossy fibers. In contrast, cholecystokinin was decreased in mossy fibers. Comparatively small differences were observed between wild-type and transgenic mice with regard to tyrosine hydroxylase (noradrenergic but also dopaminergic fibers) and acetylcholine esterase (mainly cholinergic fibers). The increase of neuropeptides in dystrophic fibers in this model may represent a response to nerve injury caused by the amyloid accumulation and may reflect attempts to counteract degeneration by initiating protective and/or regenerative processes." @default.
• W2007489114 created "2016-06-24" @default.
• W2007489114 creator A5005949087 @default.
• W2007489114 creator A5047542970 @default.
• W2007489114 creator A5051812482 @default.
• W2007489114 creator A5062811719 @default.
• W2007489114 creator A5077494149 @default.
• W2007489114 creator A5078930013 @default.
• W2007489114 creator A5084202865 @default.
• W2007489114 date "2003-12-01" @default.
• W2007489114 modified "2023-09-30" @default.
• W2007489114 title "Neuropeptide alterations in the hippocampal formation and cortex of transgenic mice overexpressing β-amyloid precursor protein (APP) with the Swedish double mutation (APP23)" @default.
• W2007489114 cites W1484830181 @default.
• W2007489114 cites W1522973841 @default.
• W2007489114 cites W1546812311 @default.
• W2007489114 cites W1572812739 @default.
• W2007489114 cites W1652739389 @default.
• W2007489114 cites W1752318600 @default.
• W2007489114 cites W1758831574 @default.
• W2007489114 cites W1808133217 @default.
• W2007489114 cites W1918909705 @default.
• W2007489114 cites W1970363870 @default.
• W2007489114 cites W1971194087 @default.
• W2007489114 cites W1971857467 @default.
• W2007489114 cites W1972784541 @default.
• W2007489114 cites W1975695500 @default.
• W2007489114 cites W1978238621 @default.
• W2007489114 cites W1982523698 @default.
• W2007489114 cites W1984865373 @default.
• W2007489114 cites W1987882483 @default.
• W2007489114 cites W1993602125 @default.
• W2007489114 cites W1993852926 @default.
• W2007489114 cites W1995344309 @default.
• W2007489114 cites W1998901000 @default.
• W2007489114 cites W1999631936 @default.
• W2007489114 cites W2000526801 @default.
• W2007489114 cites W2002581515 @default.
• W2007489114 cites W2003523284 @default.
• W2007489114 cites W2004882894 @default.
• W2007489114 cites W2005978992 @default.
• W2007489114 cites W2006409771 @default.
• W2007489114 cites W2013228938 @default.
• W2007489114 cites W2015470781 @default.
• W2007489114 cites W2017743538 @default.
• W2007489114 cites W2018126125 @default.
• W2007489114 cites W2021075309 @default.
• W2007489114 cites W2021181758 @default.
• W2007489114 cites W2021243398 @default.
• W2007489114 cites W2028394019 @default.
• W2007489114 cites W2030641075 @default.
• W2007489114 cites W2032920422 @default.
• W2007489114 cites W2033979848 @default.
• W2007489114 cites W2034042755 @default.
• W2007489114 cites W2035176443 @default.
• W2007489114 cites W2035187847 @default.
• W2007489114 cites W2036288989 @default.
• W2007489114 cites W2037288595 @default.
• W2007489114 cites W2039950820 @default.
• W2007489114 cites W2042060280 @default.
• W2007489114 cites W2042794149 @default.
• W2007489114 cites W2045153164 @default.
• W2007489114 cites W2045811240 @default.
• W2007489114 cites W2046209489 @default.
• W2007489114 cites W2046847750 @default.
• W2007489114 cites W2048365745 @default.
• W2007489114 cites W2052742260 @default.
• W2007489114 cites W2054579183 @default.
• W2007489114 cites W2058020736 @default.
• W2007489114 cites W2058723245 @default.
• W2007489114 cites W2058814496 @default.
• W2007489114 cites W2060183661 @default.
• W2007489114 cites W2074263699 @default.
• W2007489114 cites W2075886101 @default.
• W2007489114 cites W2081881251 @default.
• W2007489114 cites W2083633251 @default.
• W2007489114 cites W2087603175 @default.
• W2007489114 cites W2090811490 @default.
• W2007489114 cites W2091465211 @default.
• W2007489114 cites W2092217359 @default.
• W2007489114 cites W2095011840 @default.
• W2007489114 cites W2096931479 @default.
• W2007489114 cites W2111344548 @default.
• W2007489114 cites W2124811923 @default.
• W2007489114 cites W2126793161 @default.
• W2007489114 cites W2126800086 @default.
• W2007489114 cites W2144212564 @default.
• W2007489114 cites W2148371215 @default.
• W2007489114 cites W2156657510 @default.
• W2007489114 cites W2168500751 @default.
• W2007489114 cites W2169308121 @default.
• W2007489114 cites W2177396885 @default.
• W2007489114 cites W2561857908 @default.
• W2007489114 cites W4247529632 @default.
• W2007489114 doi "https://doi.org/10.1016/j.nbd.2003.08.003" @default.
• W2007489114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14678773" @default.
• W2007489114 hasPublicationYear "2003" @default.
• W2007489114 type Work @default.
• W2007489114 sameAs 2007489114 @default.

• next