FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007490925> ?p ?o ?g. }

• W2007490925 endingPage "553" @default.
• W2007490925 startingPage "550" @default.
• W2007490925 abstract "Long noncoding RNA prostate cancer gene antigen 3 (PCA3) is one of the most prostate cancer-specific genes at present. Consequently, the prostate-specific expression and the sharp up-regulation of PCA3 RNA in prostate cancer suggest a unique transcriptional regulation, which possibly can be attributed to promoter polymorphism. In this study, we investigated a short tandem repeat (STR) polymorphism of TAAA in the promoter region of PCA3 gene found in our previous study in prostate cancer (PCa) patients and benign prostatic hypertrophy (BPH) patients, aiming to evaluate the association between the STR and increased risk for PCa. 120 PCa cases and 120 benign prostatic hypertrophy (BPH) cases were identified among participants. The region encompassing the TAAA repeat was amplified with a specific primer set we designed and screened by PCR-based cloning and sequencing in paired peripheral blood leukocytes and prostate tissues. Genotype-specific risks were estimated as odds ratios (ORs) associated with 95% confidence intervals (CIs) and adjusted for age by means of unconditional logistic regression. 5 PCA3 TAAA STR polymorphisms and 8 genotypes were found in both peripheral blood leukocytes and prostate tissues, the carriers with more TAAA repeats were associated with increased risk for PCa than individuals having less TAAA repeats. Interestingly, 18 (15.0%) of 120 PCa patients had more (TAAA)n repeats in prostate tissues than that in peripheral blood leukocytes, and 3 (2.5%) of 120 had less (TAAA)n repeats in prostate tissues. The results of this study suggest that short tandem repeat polymorphism of TAAA in the promoter region of PCA3 gene is a risk-increasing factor for prostate cancer in the Chinese population. In addition to the hereditary factor, the insertion mutation of (TAAA)n in a local tissue maybe another mechanism of the onset of PCa." @default.
• W2007490925 created "2016-06-24" @default.
• W2007490925 creator A5005295554 @default.
• W2007490925 creator A5005659380 @default.
• W2007490925 creator A5016839576 @default.
• W2007490925 creator A5028056496 @default.
• W2007490925 creator A5029123913 @default.
• W2007490925 creator A5049051557 @default.
• W2007490925 creator A5056723401 @default.
• W2007490925 creator A5060314863 @default.
• W2007490925 creator A5064425890 @default.
• W2007490925 creator A5071603850 @default.
• W2007490925 creator A5078493025 @default.
• W2007490925 creator A5087715445 @default.
• W2007490925 date "2014-12-01" @default.
• W2007490925 modified "2023-09-27" @default.
• W2007490925 title "Long noncoding RNA PCA3 gene promoter region is related to the risk of prostate cancer on Chinese males" @default.
• W2007490925 cites W1565276921 @default.
• W2007490925 cites W2012384006 @default.
• W2007490925 cites W2028909212 @default.
• W2007490925 cites W2085450529 @default.
• W2007490925 cites W2091288012 @default.
• W2007490925 cites W2116205673 @default.
• W2007490925 cites W2116329478 @default.
• W2007490925 cites W2158734599 @default.
• W2007490925 doi "https://doi.org/10.1016/j.yexmp.2014.11.005" @default.
• W2007490925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25445501" @default.
• W2007490925 hasPublicationYear "2014" @default.
• W2007490925 type Work @default.
• W2007490925 sameAs 2007490925 @default.
• W2007490925 citedByCount "12" @default.
• W2007490925 countsByYear W20074909252015 @default.
• W2007490925 countsByYear W20074909252016 @default.
• W2007490925 countsByYear W20074909252018 @default.
• W2007490925 countsByYear W20074909252020 @default.
• W2007490925 countsByYear W20074909252021 @default.
• W2007490925 countsByYear W20074909252023 @default.
• W2007490925 crossrefType "journal-article" @default.
• W2007490925 hasAuthorship W2007490925A5005295554 @default.
• W2007490925 hasAuthorship W2007490925A5005659380 @default.
• W2007490925 hasAuthorship W2007490925A5016839576 @default.
• W2007490925 hasAuthorship W2007490925A5028056496 @default.
• W2007490925 hasAuthorship W2007490925A5029123913 @default.
• W2007490925 hasAuthorship W2007490925A5049051557 @default.
• W2007490925 hasAuthorship W2007490925A5056723401 @default.
• W2007490925 hasAuthorship W2007490925A5060314863 @default.
• W2007490925 hasAuthorship W2007490925A5064425890 @default.
• W2007490925 hasAuthorship W2007490925A5071603850 @default.
• W2007490925 hasAuthorship W2007490925A5078493025 @default.
• W2007490925 hasAuthorship W2007490925A5087715445 @default.
• W2007490925 hasConcept C104317684 @default.
• W2007490925 hasConcept C121608353 @default.
• W2007490925 hasConcept C126322002 @default.
• W2007490925 hasConcept C135763542 @default.
• W2007490925 hasConcept C141231307 @default.
• W2007490925 hasConcept C143998085 @default.
• W2007490925 hasConcept C156957248 @default.
• W2007490925 hasConcept C27149982 @default.
• W2007490925 hasConcept C2776235491 @default.
• W2007490925 hasConcept C2780192828 @default.
• W2007490925 hasConcept C502942594 @default.
• W2007490925 hasConcept C54355233 @default.
• W2007490925 hasConcept C71924100 @default.
• W2007490925 hasConcept C86803240 @default.
• W2007490925 hasConcept C87874733 @default.
• W2007490925 hasConceptScore W2007490925C104317684 @default.
• W2007490925 hasConceptScore W2007490925C121608353 @default.
• W2007490925 hasConceptScore W2007490925C126322002 @default.
• W2007490925 hasConceptScore W2007490925C135763542 @default.
• W2007490925 hasConceptScore W2007490925C141231307 @default.
• W2007490925 hasConceptScore W2007490925C143998085 @default.
• W2007490925 hasConceptScore W2007490925C156957248 @default.
• W2007490925 hasConceptScore W2007490925C27149982 @default.
• W2007490925 hasConceptScore W2007490925C2776235491 @default.
• W2007490925 hasConceptScore W2007490925C2780192828 @default.
• W2007490925 hasConceptScore W2007490925C502942594 @default.
• W2007490925 hasConceptScore W2007490925C54355233 @default.
• W2007490925 hasConceptScore W2007490925C71924100 @default.
• W2007490925 hasConceptScore W2007490925C86803240 @default.
• W2007490925 hasConceptScore W2007490925C87874733 @default.
• W2007490925 hasFunder F4320321001 @default.
• W2007490925 hasIssue "3" @default.
• W2007490925 hasLocation W20074909251 @default.
• W2007490925 hasLocation W20074909252 @default.
• W2007490925 hasOpenAccess W2007490925 @default.
• W2007490925 hasPrimaryLocation W20074909251 @default.
• W2007490925 hasRelatedWork W1980245127 @default.
• W2007490925 hasRelatedWork W1983229492 @default.
• W2007490925 hasRelatedWork W2014821335 @default.
• W2007490925 hasRelatedWork W2019340165 @default.
• W2007490925 hasRelatedWork W2021846196 @default.
• W2007490925 hasRelatedWork W2132803044 @default.
• W2007490925 hasRelatedWork W2166387306 @default.
• W2007490925 hasRelatedWork W2376423713 @default.
• W2007490925 hasRelatedWork W2591376766 @default.
• W2007490925 hasRelatedWork W2799343643 @default.
• W2007490925 hasVolume "97" @default.
• W2007490925 isParatext "false" @default.

• next