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• W2007496445 abstract "During unequal cell divisions a mitotic spindle is eccentrically positioned before cell cleavage. To determine the basis of the net force imbalance that causes spindle displacement in one-cell Caenorhabditis elegans embryos, we fragmented centrosomes with an ultraviolet laser. Analysis of the mean and variance of fragment speeds suggests that the force imbalance is due to a larger number of force generators pulling on astral microtubules of the posterior aster relative to the anterior aster. Moreover, activation of heterotrimeric guanine nucleotide- binding protein (Gprotein) alpha subunits is required to generate these astral forces." @default.
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• W2007496445 date "2003-07-25" @default.
• W2007496445 modified "2023-10-03" @default.
• W2007496445 title "The Distribution of Active Force Generators Controls Mitotic Spindle Position" @default.
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• W2007496445 doi "https://doi.org/10.1126/science.1086560" @default.
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