FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007497844> ?p ?o ?g. }

• W2007497844 abstract "Abstract The naked β sheet, a newly recognized motif of protein structure, exhibits ordered surfaces in the absence of a conventional hydrophobic core. A model is provided by an archaeal Zn ribbon homologous to eukaryotic RNA polymerase II subunit 9 (RPB9). This subunit, which regulates transcriptional start-site selection and downstream pausing, contains Zn(2+)-binding motifs similar to those of general transcription factors TFIIB and TFIIS. Interestingly, distance-geometry yields two models of the archaeal Zn ribbon differing in the orientation of a conserved tyrosine side chain on the well-ordered surface of the naked β-sheet. The models are equally consistent with conventional restraints and otherwise contain indistinguishable structural features, including a tetrahedral Cys(4) Zn(2+)-binding sites, four antiparallel β-strands, and disordered loop. Due to the change in tyrosine orientation and correlated changes in the configuration of neighboring side chains, the two models predict inequivalent patterns of aromatic ring-current shifts. The observed secondary shifts of adjoining resonances are shown to be consistent with one model but not the other. In the consistent model the surface of the β-sheet contains successive aromatic edge-to-face contacts in accord with semi-classical and ab initio potentials. We speculate that the aromatic-rich surface of the hyperthermophilic RPB9 domain contributes its thermodynamic stability and provides a nucleic-acid-binding site in the eukaryotic and archaeal transcriptional machinery. The present study demonstrates how the reduced dimensionality of a surface can lead to ambiguities in the interpretation of nuclear Overhauser enhancements. The results illustrate the utility of chemical shifts at such a surface in the cross-validation of a high-resolution solution structure." @default.
• W2007497844 created "2016-06-24" @default.
• W2007497844 creator A5040040696 @default.
• W2007497844 creator A5060301202 @default.
• W2007497844 creator A5076264613 @default.
• W2007497844 date "2000-01-01" @default.
• W2007497844 modified "2023-10-14" @default.
• W2007497844 title "Aromatic Ring Currents at a Protein Surface: Use of1H-NMR Chemical Shifts to Refine the Structure of a Naked β Sheet" @default.
• W2007497844 cites W104793819 @default.
• W2007497844 cites W1486412470 @default.
• W2007497844 cites W1541258411 @default.
• W2007497844 cites W1595719919 @default.
• W2007497844 cites W1872921923 @default.
• W2007497844 cites W1964659291 @default.
• W2007497844 cites W1967800362 @default.
• W2007497844 cites W1973621188 @default.
• W2007497844 cites W1976008991 @default.
• W2007497844 cites W1982134034 @default.
• W2007497844 cites W1985971672 @default.
• W2007497844 cites W1987911801 @default.
• W2007497844 cites W1988518107 @default.
• W2007497844 cites W1989061563 @default.
• W2007497844 cites W1990329135 @default.
• W2007497844 cites W1990870692 @default.
• W2007497844 cites W1992343825 @default.
• W2007497844 cites W1992633471 @default.
• W2007497844 cites W1992933392 @default.
• W2007497844 cites W1993926172 @default.
• W2007497844 cites W1994424584 @default.
• W2007497844 cites W1999723996 @default.
• W2007497844 cites W2009463705 @default.
• W2007497844 cites W2013929222 @default.
• W2007497844 cites W2015504137 @default.
• W2007497844 cites W2016088806 @default.
• W2007497844 cites W2020351375 @default.
• W2007497844 cites W2027238103 @default.
• W2007497844 cites W2028086550 @default.
• W2007497844 cites W2030333654 @default.
• W2007497844 cites W2030901966 @default.
• W2007497844 cites W2031964894 @default.
• W2007497844 cites W2037122000 @default.
• W2007497844 cites W2039438415 @default.
• W2007497844 cites W2042698657 @default.
• W2007497844 cites W2045950270 @default.
• W2007497844 cites W2052709323 @default.
• W2007497844 cites W2056835334 @default.
• W2007497844 cites W2057953060 @default.
• W2007497844 cites W2059392350 @default.
• W2007497844 cites W2061144516 @default.
• W2007497844 cites W2061826297 @default.
• W2007497844 cites W2061867098 @default.
• W2007497844 cites W2063291840 @default.
• W2007497844 cites W2063649882 @default.
• W2007497844 cites W2063753591 @default.
• W2007497844 cites W2078061615 @default.
• W2007497844 cites W2080796053 @default.
• W2007497844 cites W2091463495 @default.
• W2007497844 cites W2091609794 @default.
• W2007497844 cites W2094060360 @default.
• W2007497844 cites W2094186244 @default.
• W2007497844 cites W2103281864 @default.
• W2007497844 cites W2105956461 @default.
• W2007497844 cites W2111440759 @default.
• W2007497844 cites W2114226358 @default.
• W2007497844 cites W2115061130 @default.
• W2007497844 cites W2115125406 @default.
• W2007497844 cites W2116493634 @default.
• W2007497844 cites W2120920712 @default.
• W2007497844 cites W2122805799 @default.
• W2007497844 cites W2127881785 @default.
• W2007497844 cites W2131784297 @default.
• W2007497844 cites W2132652139 @default.
• W2007497844 cites W2133956643 @default.
• W2007497844 cites W2148521301 @default.
• W2007497844 cites W2152927202 @default.
• W2007497844 cites W2170565831 @default.
• W2007497844 cites W2329156128 @default.
• W2007497844 cites W2418414567 @default.
• W2007497844 cites W24674038 @default.
• W2007497844 cites W2917836704 @default.
• W2007497844 cites W2923404749 @default.
• W2007497844 cites W2949250147 @default.
• W2007497844 doi "https://doi.org/10.1080/07391102.2000.10506609" @default.
• W2007497844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22607412" @default.
• W2007497844 hasPublicationYear "2000" @default.
• W2007497844 type Work @default.
• W2007497844 sameAs 2007497844 @default.
• W2007497844 citedByCount "1" @default.
• W2007497844 crossrefType "journal-article" @default.
• W2007497844 hasAuthorship W2007497844A5040040696 @default.
• W2007497844 hasAuthorship W2007497844A5060301202 @default.
• W2007497844 hasAuthorship W2007497844A5076264613 @default.
• W2007497844 hasConcept C111429119 @default.
• W2007497844 hasConcept C115260700 @default.
• W2007497844 hasConcept C121332964 @default.
• W2007497844 hasConcept C12554922 @default.
• W2007497844 hasConcept C142089489 @default.
• W2007497844 hasConcept C147789679 @default.
• W2007497844 hasConcept C159547669 @default.
• W2007497844 hasConcept C178790620 @default.

• next