FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007499520> ?p ?o ?g. }

• W2007499520 endingPage "13255" @default.
• W2007499520 startingPage "13250" @default.
• W2007499520 abstract "Neuronal signaling requires that synaptic proteins be appropriately localized within the cell and regulated there. In mammalian neurons, polyribosomes are found not just in the cell body, but also in dendrites where they are concentrated within or beneath the dendritic spine. The α subunit of Ca 2+ -calmodulin-dependent protein kinase II (CaMKIIα) is one of only five mRNAs known to be present within the dendrites, as well as in the soma of neurons. This targeted subcellular localization of the mRNA for CaMKIIα provides a possible cell biological mechanism both for controlling the distribution of the cognate protein and for regulating independently the level of protein expression in individual dendritic spines. To characterize the cis-acting elements involved in the localization of dendritic mRNA we have produced two lines of transgenic mice in which the CaMKIIα promoter is used to drive the expression of a lacZ transcript, which either contains or lacks the 3′-untranslated region of the CaMKIIα gene. Although both lines of mice show expression in forebrain neurons that parallels the expression of the endogenous CaMKIIα gene, only the lacZ transcripts bearing the 3′-untranslated region are localized to dendrites. The β-galactosidase protein shows a variable level of expression along the dendritic shaft and within dendritic spines, which suggests that neurons can control the local biochemistry of the dendrite either through differential localization of the mRNA or variations in the translational efficiency at different sites along the dendrite." @default.
• W2007499520 created "2016-06-24" @default.
• W2007499520 creator A5019724227 @default.
• W2007499520 creator A5031821493 @default.
• W2007499520 creator A5034071817 @default.
• W2007499520 creator A5052780363 @default.
• W2007499520 date "1996-11-12" @default.
• W2007499520 modified "2023-10-13" @default.
• W2007499520 title "The 3′-untranslated region of CaMKIIα is a cis-acting signal for the localization and translation of mRNA in dendrites" @default.
• W2007499520 cites W1455903824 @default.
• W2007499520 cites W1608464482 @default.
• W2007499520 cites W1652058896 @default.
• W2007499520 cites W1970409943 @default.
• W2007499520 cites W1979792481 @default.
• W2007499520 cites W2005744880 @default.
• W2007499520 cites W2008062776 @default.
• W2007499520 cites W2018662966 @default.
• W2007499520 cites W2024973552 @default.
• W2007499520 cites W2039729151 @default.
• W2007499520 cites W2041269154 @default.
• W2007499520 cites W2042834556 @default.
• W2007499520 cites W2046909406 @default.
• W2007499520 cites W2049511526 @default.
• W2007499520 cites W2054975255 @default.
• W2007499520 cites W2057977645 @default.
• W2007499520 cites W2062828269 @default.
• W2007499520 cites W2066174099 @default.
• W2007499520 cites W2076776277 @default.
• W2007499520 cites W2078084904 @default.
• W2007499520 cites W2080152563 @default.
• W2007499520 cites W2090429649 @default.
• W2007499520 cites W2094898557 @default.
• W2007499520 cites W2095832516 @default.
• W2007499520 cites W2107190396 @default.
• W2007499520 cites W2143051510 @default.
• W2007499520 cites W2143991789 @default.
• W2007499520 cites W2153398368 @default.
• W2007499520 cites W2299911927 @default.
• W2007499520 cites W2329977174 @default.
• W2007499520 cites W4299832967 @default.
• W2007499520 doi "https://doi.org/10.1073/pnas.93.23.13250" @default.
• W2007499520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/24079" @default.
• W2007499520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8917577" @default.
• W2007499520 hasPublicationYear "1996" @default.
• W2007499520 type Work @default.
• W2007499520 sameAs 2007499520 @default.
• W2007499520 citedByCount "308" @default.
• W2007499520 countsByYear W20074995202012 @default.
• W2007499520 countsByYear W20074995202013 @default.
• W2007499520 countsByYear W20074995202014 @default.
• W2007499520 countsByYear W20074995202015 @default.
• W2007499520 countsByYear W20074995202016 @default.
• W2007499520 countsByYear W20074995202017 @default.
• W2007499520 countsByYear W20074995202018 @default.
• W2007499520 countsByYear W20074995202019 @default.
• W2007499520 countsByYear W20074995202020 @default.
• W2007499520 countsByYear W20074995202021 @default.
• W2007499520 countsByYear W20074995202022 @default.
• W2007499520 countsByYear W20074995202023 @default.
• W2007499520 crossrefType "journal-article" @default.
• W2007499520 hasAuthorship W2007499520A5019724227 @default.
• W2007499520 hasAuthorship W2007499520A5031821493 @default.
• W2007499520 hasAuthorship W2007499520A5034071817 @default.
• W2007499520 hasAuthorship W2007499520A5052780363 @default.
• W2007499520 hasBestOaLocation W20074995201 @default.
• W2007499520 hasConcept C104317684 @default.
• W2007499520 hasConcept C105580179 @default.
• W2007499520 hasConcept C148762608 @default.
• W2007499520 hasConcept C149364088 @default.
• W2007499520 hasConcept C150194340 @default.
• W2007499520 hasConcept C169760540 @default.
• W2007499520 hasConcept C174884520 @default.
• W2007499520 hasConcept C22667442 @default.
• W2007499520 hasConcept C2524010 @default.
• W2007499520 hasConcept C33923547 @default.
• W2007499520 hasConcept C54355233 @default.
• W2007499520 hasConcept C65666806 @default.
• W2007499520 hasConcept C67705224 @default.
• W2007499520 hasConcept C84248122 @default.
• W2007499520 hasConcept C86803240 @default.
• W2007499520 hasConcept C88478588 @default.
• W2007499520 hasConcept C89604277 @default.
• W2007499520 hasConcept C95444343 @default.
• W2007499520 hasConceptScore W2007499520C104317684 @default.
• W2007499520 hasConceptScore W2007499520C105580179 @default.
• W2007499520 hasConceptScore W2007499520C148762608 @default.
• W2007499520 hasConceptScore W2007499520C149364088 @default.
• W2007499520 hasConceptScore W2007499520C150194340 @default.
• W2007499520 hasConceptScore W2007499520C169760540 @default.
• W2007499520 hasConceptScore W2007499520C174884520 @default.
• W2007499520 hasConceptScore W2007499520C22667442 @default.
• W2007499520 hasConceptScore W2007499520C2524010 @default.
• W2007499520 hasConceptScore W2007499520C33923547 @default.
• W2007499520 hasConceptScore W2007499520C54355233 @default.
• W2007499520 hasConceptScore W2007499520C65666806 @default.
• W2007499520 hasConceptScore W2007499520C67705224 @default.
• W2007499520 hasConceptScore W2007499520C84248122 @default.
• W2007499520 hasConceptScore W2007499520C86803240 @default.

• next