FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007500163> ?p ?o ?g. }

• W2007500163 endingPage "151" @default.
• W2007500163 startingPage "145" @default.
• W2007500163 abstract "Malignant melanoma is a disease with high mortality rate caused by rapid metastasis. Cell motility is physically and biochemically restricted by cadherin-mediated cell interactions and signalling pathways, and alterations in cadherin expression strongly correlate with E to N-cadherin switch as well as the metastasis and progression of tumours. Contrary to E-cadherin, N-cadherin plays an important role in stimulating processes of cell division, migration, differentiation and death. In this study we investigated the role of N-cadherin in proliferation and AKT, ERK, beta-catenin signalling pathway in human melanoma cells: WM793(VGP), WM115(VGP) from the primary tumor site, as well as Lu1205(lung) and WM266-4(skin) from metastatic sites. N-cadherin, pAKT(S473), β-catenin, pERK1/2(T202/Y204), cyclin D1, cyclin D3, cyclin-dependent kinases CDK4, CDK6, and p15, p16, p21, p27 inhibitors expression was determined by western blot analysis. The study on proliferation of cells was performed with the use of BrdU incorporation and crystal violet staining assays. Knock-out of N-cadherin gene expression by siRNA process reduced the expression of: pAKT(S473), pERK1/2(T202/Y204), betacatenin, cyclin D1, cyclin D3 , cyclin-dependent kinases CDK4, CDK6 while increasing expression of cell cycle inhibitors p21 and p27, and significantly decreased cell proliferation (50-70%). The collected data indicate that N-cadherin mediates the effect of cell cycle in G1 phase by AKT, β-catenin, and ERK signalling pathway. These results suggest that increased expression of N-cadherin significantly contributes to the increased invasive potential of melanoma cells. Silencing of N-cadherin arrests cell growth at G1 phase and inhibits the entry into S-phase which is of great importance as to its possible future use in cancer treatment. Keywords: AKT, β-catenin, cell cycle, ERK, melanoma, N-cadherin, proliferation, siRNA, Malignant melanoma, tumours" @default.
• W2007500163 created "2016-06-24" @default.
• W2007500163 creator A5032742421 @default.
• W2007500163 creator A5049100519 @default.
• W2007500163 creator A5057799391 @default.
• W2007500163 date "2012-01-01" @default.
• W2007500163 modified "2023-09-25" @default.
• W2007500163 title "The Inhibition of Cell Proliferation Using Silencing of N-Cadherin Gene by siRNA Process in Human Melanoma Cell Lines" @default.
• W2007500163 cites W1492304029 @default.
• W2007500163 cites W1509669696 @default.
• W2007500163 cites W1528955439 @default.
• W2007500163 cites W1541209562 @default.
• W2007500163 cites W1554815317 @default.
• W2007500163 cites W1975912195 @default.
• W2007500163 cites W1981147697 @default.
• W2007500163 cites W1989215255 @default.
• W2007500163 cites W1992079408 @default.
• W2007500163 cites W1993778562 @default.
• W2007500163 cites W2014757368 @default.
• W2007500163 cites W2026262319 @default.
• W2007500163 cites W2030090912 @default.
• W2007500163 cites W2036521316 @default.
• W2007500163 cites W2050984994 @default.
• W2007500163 cites W2073079990 @default.
• W2007500163 cites W2082952854 @default.
• W2007500163 cites W2089343314 @default.
• W2007500163 cites W2090184497 @default.
• W2007500163 cites W2136316836 @default.
• W2007500163 cites W2161950842 @default.
• W2007500163 cites W2169345069 @default.
• W2007500163 cites W2428747277 @default.
• W2007500163 cites W64416022 @default.
• W2007500163 doi "https://doi.org/10.2174/092986712803414006" @default.
• W2007500163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22300088" @default.
• W2007500163 hasPublicationYear "2012" @default.
• W2007500163 type Work @default.
• W2007500163 sameAs 2007500163 @default.
• W2007500163 citedByCount "30" @default.
• W2007500163 countsByYear W20075001632012 @default.
• W2007500163 countsByYear W20075001632013 @default.
• W2007500163 countsByYear W20075001632014 @default.
• W2007500163 countsByYear W20075001632015 @default.
• W2007500163 countsByYear W20075001632016 @default.
• W2007500163 countsByYear W20075001632017 @default.
• W2007500163 countsByYear W20075001632018 @default.
• W2007500163 countsByYear W20075001632019 @default.
• W2007500163 countsByYear W20075001632020 @default.
• W2007500163 countsByYear W20075001632021 @default.
• W2007500163 countsByYear W20075001632022 @default.
• W2007500163 countsByYear W20075001632023 @default.
• W2007500163 crossrefType "journal-article" @default.
• W2007500163 hasAuthorship W2007500163A5032742421 @default.
• W2007500163 hasAuthorship W2007500163A5049100519 @default.
• W2007500163 hasAuthorship W2007500163A5057799391 @default.
• W2007500163 hasBestOaLocation W20075001632 @default.
• W2007500163 hasConcept C104317684 @default.
• W2007500163 hasConcept C11882975 @default.
• W2007500163 hasConcept C119056186 @default.
• W2007500163 hasConcept C1491633281 @default.
• W2007500163 hasConcept C153911025 @default.
• W2007500163 hasConcept C184235292 @default.
• W2007500163 hasConcept C185592680 @default.
• W2007500163 hasConcept C199649820 @default.
• W2007500163 hasConcept C199835354 @default.
• W2007500163 hasConcept C2777093181 @default.
• W2007500163 hasConcept C2781403221 @default.
• W2007500163 hasConcept C29537977 @default.
• W2007500163 hasConcept C502942594 @default.
• W2007500163 hasConcept C55493867 @default.
• W2007500163 hasConcept C57074206 @default.
• W2007500163 hasConcept C62112901 @default.
• W2007500163 hasConcept C62478195 @default.
• W2007500163 hasConcept C75217442 @default.
• W2007500163 hasConcept C86803240 @default.
• W2007500163 hasConcept C95444343 @default.
• W2007500163 hasConceptScore W2007500163C104317684 @default.
• W2007500163 hasConceptScore W2007500163C11882975 @default.
• W2007500163 hasConceptScore W2007500163C119056186 @default.
• W2007500163 hasConceptScore W2007500163C1491633281 @default.
• W2007500163 hasConceptScore W2007500163C153911025 @default.
• W2007500163 hasConceptScore W2007500163C184235292 @default.
• W2007500163 hasConceptScore W2007500163C185592680 @default.
• W2007500163 hasConceptScore W2007500163C199649820 @default.
• W2007500163 hasConceptScore W2007500163C199835354 @default.
• W2007500163 hasConceptScore W2007500163C2777093181 @default.
• W2007500163 hasConceptScore W2007500163C2781403221 @default.
• W2007500163 hasConceptScore W2007500163C29537977 @default.
• W2007500163 hasConceptScore W2007500163C502942594 @default.
• W2007500163 hasConceptScore W2007500163C55493867 @default.
• W2007500163 hasConceptScore W2007500163C57074206 @default.
• W2007500163 hasConceptScore W2007500163C62112901 @default.
• W2007500163 hasConceptScore W2007500163C62478195 @default.
• W2007500163 hasConceptScore W2007500163C75217442 @default.
• W2007500163 hasConceptScore W2007500163C86803240 @default.
• W2007500163 hasConceptScore W2007500163C95444343 @default.
• W2007500163 hasIssue "1" @default.
• W2007500163 hasLocation W20075001631 @default.
• W2007500163 hasLocation W20075001632 @default.

• next