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• W2007502435 abstract "As opposed to the prokaryotic cell which must adapt its intracellular processes to face the challenge posed by changing environments, Eukaryotic cell needs to contribute its share to maintain constancy of It. milieu interieur. Indeed, the very concept of homeostasis calls for coordination within and between the various tissues and organs towards realization and expression of pre-determined reaction patterns. Perhaps the most characteristic feature of a neoplastic cell is acquisition of an autonomy over the morphofunctional limits imposed by the microenvironment in a cellular community. This reasoning may easily be used to explain the autonomous sort of transformation exhibited by normal cells in culture. On the other hand, development is believed to require cell-cell flow of ‘morphogens’ at varying distances from the morphogen source,*3 thereby commiting the cellular communities to restraints dictated by predetermined differentiation patterns. 111 the integrated organism, various levels of communication may be distinguished that ensure this functional co-operation between the component parts. At the subcellular level, the nucleo-cytoplasmic exchange of information is obviously well established.17 Between adjacent cells, direct cell-cell interactions may be mediated either by modification of cellular membranes, or through intercellular junctions. Continuity of conversation between cells located at some distance is assured by chemical messengers in the form of hormones, vasoactive or chemotactic substances. Here, the extracellular compartment plays the necessary role to co-ordinate contact between the control-initiating and sensitive cells, as well as the organs that respond to the bioactive substance via retroactive adjustments in various metabolite pools. Apart from these levels of control, a phenomenon such as cellular co-operation requires successive participation of various distinct cell types to obtain completion of a single biological event, viz: immunogenesis. In its simplest form, the question may be asked whether such co-operation is called for in other types of biological processes, and in various stages of differentiation; and whether these systems would share some analogy. This is the focal point of the present review, although selected other systems have also been included in the perspective. After a brief survey of instances where this type of intercellular co-operation has been documented or indicated, efforts are made to trace a possible common origin that might explain a diversity of response patterns in various stages of differentiation. This review is not intended to be an exhaustive account of the literature on the various forms of cellular interactions mentioned above. Rather, relevant features from each system have been taken to arrive at a possible level of regulation which has hitherto remained elusive. The references are not meant to establish priorities but to lead the reader to an appropriate source reference. For these reasons, mention is often made to existing review articles rather than to descriptions of particular details." @default.
• W2007502435 created "2016-06-24" @default.
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• W2007502435 date "1974-12-01" @default.
• W2007502435 modified "2023-09-25" @default.
• W2007502435 title "Intercellular Interactions in Eukaryotic Homeostasis" @default.
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• W2007502435 doi "https://doi.org/10.1111/j.1432-0436.1974.tb00374.x" @default.
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