Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007504088> ?p ?o ?g. }
- W2007504088 endingPage "1620" @default.
- W2007504088 startingPage "1611" @default.
- W2007504088 abstract "To investigate the antitumor activities of an anti-ErbB2 scFv-Fc-interleukin 2 (IL-2) fusion protein (HFI) in vitro and in vivo.Fusion protein HFI was constructed. The efficacy of HFI in mediating tumor cell lysis was determined by colorimetric lactate dehydrogenase release assays. The antitumor activity of HFI was evaluated in tumor xenograft models.The fusion protein was folded as a homodimer formed by covalently linking Fc portions and it retained ErbB2 specificity and IL-2 biological activity. HFI mediated antibody-dependent cell-mediated cytotoxicity (ADCC) at low effector-to-target ratios in vitro and improved the therapeutic efficacy of IL-2 in experiments in vivo.The genetically-engineered anti-ErbB2 scFv-Fc-IL-2 fusion protein exhibited high efficiency both in mediating ADCC in vitro and significant antitumor activity in tumor xenograft models." @default.
- W2007504088 created "2016-06-24" @default.
- W2007504088 creator A5003755536 @default.
- W2007504088 creator A5008926675 @default.
- W2007504088 creator A5020955864 @default.
- W2007504088 creator A5031067040 @default.
- W2007504088 creator A5059290335 @default.
- W2007504088 creator A5060514130 @default.
- W2007504088 creator A5065435488 @default.
- W2007504088 creator A5077741672 @default.
- W2007504088 creator A5082675959 @default.
- W2007504088 creator A5089273092 @default.
- W2007504088 date "2007-10-01" @default.
- W2007504088 modified "2023-10-14" @default.
- W2007504088 title "Efficient growth inhibition of ErbB2-overexpressing tumor cells by anti-ErbB2 ScFv-Fc-IL-2 fusion protein in vitro and in vivo" @default.
- W2007504088 cites W1534715980 @default.
- W2007504088 cites W1577612079 @default.
- W2007504088 cites W1794218190 @default.
- W2007504088 cites W1963576366 @default.
- W2007504088 cites W1963674875 @default.
- W2007504088 cites W1966204823 @default.
- W2007504088 cites W1975568557 @default.
- W2007504088 cites W2009030875 @default.
- W2007504088 cites W2010480242 @default.
- W2007504088 cites W2012939857 @default.
- W2007504088 cites W2015878053 @default.
- W2007504088 cites W2023411546 @default.
- W2007504088 cites W2029385817 @default.
- W2007504088 cites W2031074321 @default.
- W2007504088 cites W2033401763 @default.
- W2007504088 cites W2036275492 @default.
- W2007504088 cites W2042123531 @default.
- W2007504088 cites W2053485292 @default.
- W2007504088 cites W2060142706 @default.
- W2007504088 cites W2065841267 @default.
- W2007504088 cites W2068602959 @default.
- W2007504088 cites W2074348188 @default.
- W2007504088 cites W2092355198 @default.
- W2007504088 cites W2095156669 @default.
- W2007504088 cites W2112670552 @default.
- W2007504088 cites W2121421904 @default.
- W2007504088 cites W2124446900 @default.
- W2007504088 cites W2138985980 @default.
- W2007504088 cites W2141393790 @default.
- W2007504088 cites W2143005230 @default.
- W2007504088 cites W2154027407 @default.
- W2007504088 cites W2168785527 @default.
- W2007504088 cites W21981275 @default.
- W2007504088 cites W2262099091 @default.
- W2007504088 cites W2317109657 @default.
- W2007504088 cites W2334517800 @default.
- W2007504088 cites W2335365056 @default.
- W2007504088 cites W272579771 @default.
- W2007504088 cites W49117486 @default.
- W2007504088 doi "https://doi.org/10.1111/j.1745-7254.2007.00622.x" @default.
- W2007504088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17883948" @default.
- W2007504088 hasPublicationYear "2007" @default.
- W2007504088 type Work @default.
- W2007504088 sameAs 2007504088 @default.
- W2007504088 citedByCount "10" @default.
- W2007504088 countsByYear W20075040882012 @default.
- W2007504088 countsByYear W20075040882013 @default.
- W2007504088 countsByYear W20075040882017 @default.
- W2007504088 countsByYear W20075040882020 @default.
- W2007504088 crossrefType "journal-article" @default.
- W2007504088 hasAuthorship W2007504088A5003755536 @default.
- W2007504088 hasAuthorship W2007504088A5008926675 @default.
- W2007504088 hasAuthorship W2007504088A5020955864 @default.
- W2007504088 hasAuthorship W2007504088A5031067040 @default.
- W2007504088 hasAuthorship W2007504088A5059290335 @default.
- W2007504088 hasAuthorship W2007504088A5060514130 @default.
- W2007504088 hasAuthorship W2007504088A5065435488 @default.
- W2007504088 hasAuthorship W2007504088A5077741672 @default.
- W2007504088 hasAuthorship W2007504088A5082675959 @default.
- W2007504088 hasAuthorship W2007504088A5089273092 @default.
- W2007504088 hasBestOaLocation W20075040881 @default.
- W2007504088 hasConcept C104317684 @default.
- W2007504088 hasConcept C109316439 @default.
- W2007504088 hasConcept C123894998 @default.
- W2007504088 hasConcept C150903083 @default.
- W2007504088 hasConcept C153911025 @default.
- W2007504088 hasConcept C185592680 @default.
- W2007504088 hasConcept C202751555 @default.
- W2007504088 hasConcept C207001950 @default.
- W2007504088 hasConcept C40677261 @default.
- W2007504088 hasConcept C40767141 @default.
- W2007504088 hasConcept C502942594 @default.
- W2007504088 hasConcept C51785407 @default.
- W2007504088 hasConcept C55493867 @default.
- W2007504088 hasConcept C86803240 @default.
- W2007504088 hasConceptScore W2007504088C104317684 @default.
- W2007504088 hasConceptScore W2007504088C109316439 @default.
- W2007504088 hasConceptScore W2007504088C123894998 @default.
- W2007504088 hasConceptScore W2007504088C150903083 @default.
- W2007504088 hasConceptScore W2007504088C153911025 @default.
- W2007504088 hasConceptScore W2007504088C185592680 @default.
- W2007504088 hasConceptScore W2007504088C202751555 @default.
- W2007504088 hasConceptScore W2007504088C207001950 @default.