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- W2007515764 abstract "The current treatment algorithm for hepatocellular carcinoma (HCC) suggests locoregional therapy (LRT) with TACE for intermediate stage disease and systemic therapy for advanced stage. In order to improve outcome combined approaches of locoregional and sorafenib are investigated. Most data on combination therapy are available for patients with intermediate HCC. These patients typically present with disease relapse on or disease progression after TACE, defining TACE as a non-curative treatment approach with a 3-year survival rate not exceeding 30%. The combination of LRT with TACE appreciates that: As sorafenib might curtail the post-TACE rise in VEGF-mediated signaling, there is a good theoretical rationale for this combination. To date, results regarding the combination of TACE and sorafenib are inconclusive due to heterogenous trial design; particularly randomized, controlled data are lacking. However, the combination of TACE with sorafenib appears to be safe and feasible in patients with intermediate (to advanced) stage HCC." @default.
- W2007515764 created "2016-06-24" @default.
- W2007515764 creator A5074552113 @default.
- W2007515764 date "2013-09-01" @default.
- W2007515764 modified "2023-09-23" @default.
- W2007515764 title "O242: Sorafenib as an adjunct to ablation or embolisation" @default.
- W2007515764 doi "https://doi.org/10.1111/jvh.12165_22" @default.
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