Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007515979> ?p ?o ?g. }
- W2007515979 endingPage "1823" @default.
- W2007515979 startingPage "1816" @default.
- W2007515979 abstract "Polo-like kinase 1 (Plk1) plays key roles in many aspects of mitosis. We have previously shown that induction of p21(Waf1) by p53 is responsible for protection of cells against adriamycin-induced polyploidy formation and mitotic catastrophe. Here we show that adriamycin treatment suppressed Plk1 expression in a p53- and p21(Waf1)-dependent manner. Ablation of p21(Waf1) inhibited the adriamycin-induced p53 activation, and this inhibition was alleviated by knockdown of Plk1, suggesting that p21(Waf1)-dependent suppression of Plk1 expression is responsible for maintaining p53 activation during stress response. Plk1 associated with p53 and disrupted its interaction with target gene promoters in cells treated with adriamycin. Overexpression of Plk1 inhibited the p53-mediated prevention of caspase-independent mitotic death, but not polyploidy formation, in adriamycin-treated cells. Together our results indicate that suppression of Plk1 by p21(Waf1) is responsible for p53-dependent protection against adriamycin-induced caspase-independent mitotic death." @default.
- W2007515979 created "2016-06-24" @default.
- W2007515979 creator A5008910259 @default.
- W2007515979 creator A5020748322 @default.
- W2007515979 creator A5091220699 @default.
- W2007515979 date "2011-11-01" @default.
- W2007515979 modified "2023-09-24" @default.
- W2007515979 title "Suppression of Polo like kinase 1 (PLK1) by p21Waf1 mediates the p53-dependent prevention of caspase-independent mitotic death" @default.
- W2007515979 cites W129960861 @default.
- W2007515979 cites W1537737236 @default.
- W2007515979 cites W1553367038 @default.
- W2007515979 cites W1650797637 @default.
- W2007515979 cites W193163883 @default.
- W2007515979 cites W1971476329 @default.
- W2007515979 cites W1972474233 @default.
- W2007515979 cites W1973617154 @default.
- W2007515979 cites W1993941887 @default.
- W2007515979 cites W1997367417 @default.
- W2007515979 cites W2001605111 @default.
- W2007515979 cites W2008257691 @default.
- W2007515979 cites W2012269771 @default.
- W2007515979 cites W2024103170 @default.
- W2007515979 cites W2025540821 @default.
- W2007515979 cites W2025702938 @default.
- W2007515979 cites W2033408779 @default.
- W2007515979 cites W2037139254 @default.
- W2007515979 cites W2039485415 @default.
- W2007515979 cites W2040235495 @default.
- W2007515979 cites W2041912628 @default.
- W2007515979 cites W2045575679 @default.
- W2007515979 cites W2045694872 @default.
- W2007515979 cites W2046024621 @default.
- W2007515979 cites W2056783630 @default.
- W2007515979 cites W2060055311 @default.
- W2007515979 cites W2070606576 @default.
- W2007515979 cites W2071748938 @default.
- W2007515979 cites W2102752109 @default.
- W2007515979 cites W2108300681 @default.
- W2007515979 cites W2110864471 @default.
- W2007515979 cites W2116820153 @default.
- W2007515979 cites W2131837045 @default.
- W2007515979 cites W2148379386 @default.
- W2007515979 cites W2150651320 @default.
- W2007515979 cites W2151085515 @default.
- W2007515979 cites W2159899189 @default.
- W2007515979 cites W2164660906 @default.
- W2007515979 cites W4323053775 @default.
- W2007515979 doi "https://doi.org/10.1016/j.cellsig.2011.06.016" @default.
- W2007515979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21726628" @default.
- W2007515979 hasPublicationYear "2011" @default.
- W2007515979 type Work @default.
- W2007515979 sameAs 2007515979 @default.
- W2007515979 citedByCount "13" @default.
- W2007515979 countsByYear W20075159792012 @default.
- W2007515979 countsByYear W20075159792013 @default.
- W2007515979 countsByYear W20075159792014 @default.
- W2007515979 countsByYear W20075159792016 @default.
- W2007515979 countsByYear W20075159792017 @default.
- W2007515979 countsByYear W20075159792020 @default.
- W2007515979 countsByYear W20075159792021 @default.
- W2007515979 crossrefType "journal-article" @default.
- W2007515979 hasAuthorship W2007515979A5008910259 @default.
- W2007515979 hasAuthorship W2007515979A5020748322 @default.
- W2007515979 hasAuthorship W2007515979A5091220699 @default.
- W2007515979 hasConcept C10447061 @default.
- W2007515979 hasConcept C146276462 @default.
- W2007515979 hasConcept C173396325 @default.
- W2007515979 hasConcept C184235292 @default.
- W2007515979 hasConcept C185592680 @default.
- W2007515979 hasConcept C186000732 @default.
- W2007515979 hasConcept C190283241 @default.
- W2007515979 hasConcept C29537977 @default.
- W2007515979 hasConcept C31573885 @default.
- W2007515979 hasConcept C502942594 @default.
- W2007515979 hasConcept C54355233 @default.
- W2007515979 hasConcept C84815855 @default.
- W2007515979 hasConcept C86803240 @default.
- W2007515979 hasConcept C93304396 @default.
- W2007515979 hasConcept C95444343 @default.
- W2007515979 hasConceptScore W2007515979C10447061 @default.
- W2007515979 hasConceptScore W2007515979C146276462 @default.
- W2007515979 hasConceptScore W2007515979C173396325 @default.
- W2007515979 hasConceptScore W2007515979C184235292 @default.
- W2007515979 hasConceptScore W2007515979C185592680 @default.
- W2007515979 hasConceptScore W2007515979C186000732 @default.
- W2007515979 hasConceptScore W2007515979C190283241 @default.
- W2007515979 hasConceptScore W2007515979C29537977 @default.
- W2007515979 hasConceptScore W2007515979C31573885 @default.
- W2007515979 hasConceptScore W2007515979C502942594 @default.
- W2007515979 hasConceptScore W2007515979C54355233 @default.
- W2007515979 hasConceptScore W2007515979C84815855 @default.
- W2007515979 hasConceptScore W2007515979C86803240 @default.
- W2007515979 hasConceptScore W2007515979C93304396 @default.
- W2007515979 hasConceptScore W2007515979C95444343 @default.
- W2007515979 hasFunder F4320311687 @default.
- W2007515979 hasFunder F4320321040 @default.
- W2007515979 hasIssue "11" @default.
- W2007515979 hasLocation W20075159791 @default.