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- W2007525344 abstract "The ability of N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4), a potent and selective noradrenergic neurotoxic compound, to modify morphine tolerance and dependence was investigated in mice. DSP-4 pretreatment, either 50 or 100 mg/kg i.p., had no effect on the development of tolerance to the analgesic effect of morphine evaluated by the tail-flick test. On the contrary, the higher dose of DSP-4 prevented repetitive vertical jumping, a major naloxone-precipitated withdrawal symptom in mice. These results demonstrate that coerulean neuronal projections are not necessary for the development of tolerance but are clearly involved in the expression of withdrawal-induced jumping in mice." @default.
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- W2007525344 title "Involvement of locus coeruleus projections in opiate withdrawal but not in opiate tolerance in mice" @default.
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- W2007525344 doi "https://doi.org/10.1016/0014-2999(96)00318-4" @default.
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