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- W2007526311 abstract "Abstract Ultradol is a new, non-steroidal, anti-inflammatory drug under clinical investigation. Sustained-release (SR) formulations, ranging from 200 to 600 mg in strength, have been developed to improve patients convenience and subsequent compliance, when compared with twice daily (b.i.d.) administration of immediate-release capsules. In vitro dissolution testing and clinical bioavailability studies have been completed for the SR formulations. A pilot bioavailability study was conducted in order to evaluate the relationship between in vitro dissolution and absorption. The computer program NONLIN was used to model both in vitro drug release and in vivo plasma concentration-time profiles. Based on the results of the pilot study and the kinetic modeling, optimum target in vitro release rates were identified. Dosage forms exhibiting these in vitro release profiles were evaluated in a bioavailability and dose proportionality study over the range of 200–600 mg daily doses. The SR formulations were bioequivalent to their respective immediate release doses and were dose-proportional. The in vivo performance was accurately predicted by in vitro dissolution data." @default.
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- W2007526311 date "1989-01-01" @default.
- W2007526311 modified "2023-09-27" @default.
- W2007526311 title "Sustained-release etodolac bioavailability and dose proportionality: correlation between in vivo and in vitro performance" @default.
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- W2007526311 doi "https://doi.org/10.1016/0378-5173(89)90110-5" @default.
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