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- W2007531479 abstract "The in-vitro uptake of four anthracyclines into leukemic cells was investigated. The accumulation was found to be dependent on the extracellular anthracycline concentration in a linear fashion. The steady state intracellular drug level was reached very quickly and was found to be correlated to the extracellular pH-value in the range between 6.4 and 7.4. Intracellular anthracycline accumulation was restricted in a leukemic subline (F 4-6 R), which was found to be 86 times more resistant to doxorubicin compared with its wild tpye (F 4-6). The importance of the initial uptake phase of anthracyclines into leukemic cells raises the question whether long-term cardioprotective anthracycline application schedules will retain the same antileukemic effect as conventional bolus injection." @default.
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- W2007531479 date "1989-01-01" @default.
- W2007531479 modified "2023-09-26" @default.
- W2007531479 title "Anthracyclintransport in sensible und resistente Leukämiezellen" @default.
- W2007531479 doi "https://doi.org/10.1055/s-2007-1025273" @default.
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