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- W2007532128 abstract "Abstract The interaction between 17 steroidal drugs and carboxymethyl- β -cyclodextrin (CM β CD) was determined by charge–transfer chromatography and the relative strength of interaction was calculated. CM β CD interacted with the majority of steroidal drugs decreasing the hydrophobicity of the guest molecules. The relative strength of interaction considerably depended on the structure of the drug molecule. The hydrophobicity parameters of the drugs significantly influenced the strength of interaction indicating the involvement of hydrophobic forces in the binding of drugs to CM β CD. The marked influence of CM β CD on the hydrophobicity of drugs suggests that this interaction may have a considerable impact on the biological properties (adsorption, uptake, half-life etc,) of drug — CM β CD complexes resulting in modified efficacy." @default.
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- W2007532128 date "1999-02-01" @default.
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- W2007532128 title "Effect of carboxymethyl- β -cyclodextrin on the hydrophobicity parameters of steroidal drugs" @default.
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- W2007532128 doi "https://doi.org/10.1016/s0144-8617(98)00110-6" @default.
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