FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007532842> ?p ?o ?g. }

• W2007532842 endingPage "142" @default.
• W2007532842 startingPage "136" @default.
• W2007532842 abstract "We studied the risk of the development of acute myeloid leukemia (AML) during initial remission in 733 consecutive children with acute lymphoid leukemia (ALL) who were treated with intensive chemotherapy. This complication was identified according to standard morphologic and cytochemical criteria in 13 patients 1.2 to 6 years (median, 3.0) after the diagnosis of ALL. At three years of follow-up, the cumulative risk of secondary AML during the first bone marrow remission was 1.6 percent (95 percent confidence limits, 0.7 and 3.5 percent); at six years, it was 4.7 percent (2 and 10 percent). The development of secondary AML was much more likely among patients with a T-cell than a non-T-cell immunophenotype (cumulative risk, 19.1 percent [6 and 47 percent] at six years). Sequential cytogenetic studies in 10 patients revealed entirely different karyotypes in 9, suggesting the induction of a second neoplasm. In eight of these patients, the blast cells had abnormalities of the 11 q23 chromosomal region, which has been associated with malignant transformation of a pluripotential stem cell. There was no evidence of loss of DNA from chromosome 5 or 7, a karyotypic change commonly observed in cases of AML secondary to treatment with alkylating agents, irradiation, or both. We conclude that there is a substantial risk of AML in patients who receive intensive treatment for ALL, especially in those with a T-cell immunophenotype, and that 11q23 chromosomal abnormalities may be important in the pathogenesis of this complication. (N Engl J Med 1989;321:136–42.)" @default.
• W2007532842 created "2016-06-24" @default.
• W2007532842 creator A5007275246 @default.
• W2007532842 creator A5012776569 @default.
• W2007532842 creator A5014628209 @default.
• W2007532842 creator A5017212847 @default.
• W2007532842 creator A5018363328 @default.
• W2007532842 creator A5019589871 @default.
• W2007532842 creator A5030075618 @default.
• W2007532842 creator A5043440650 @default.
• W2007532842 creator A5044283278 @default.
• W2007532842 creator A5054646389 @default.
• W2007532842 creator A5059983011 @default.
• W2007532842 creator A5075827511 @default.
• W2007532842 date "1989-07-20" @default.
• W2007532842 modified "2023-10-11" @default.
• W2007532842 title "Secondary Acute Myeloid Leukemia in Children Treated for Acute Lymphoid Leukemia" @default.
• W2007532842 cites W1495036323 @default.
• W2007532842 cites W1527009973 @default.
• W2007532842 cites W1590959263 @default.
• W2007532842 cites W1698998118 @default.
• W2007532842 cites W1796305773 @default.
• W2007532842 cites W1817702060 @default.
• W2007532842 cites W1829759922 @default.
• W2007532842 cites W1902751859 @default.
• W2007532842 cites W1964647930 @default.
• W2007532842 cites W1965927480 @default.
• W2007532842 cites W1967826512 @default.
• W2007532842 cites W1972254524 @default.
• W2007532842 cites W1993879858 @default.
• W2007532842 cites W2004486431 @default.
• W2007532842 cites W2005279153 @default.
• W2007532842 cites W2030916937 @default.
• W2007532842 cites W2035107007 @default.
• W2007532842 cites W2038108954 @default.
• W2007532842 cites W2039689990 @default.
• W2007532842 cites W2040183160 @default.
• W2007532842 cites W2047350408 @default.
• W2007532842 cites W2050480305 @default.
• W2007532842 cites W2051703407 @default.
• W2007532842 cites W2058599222 @default.
• W2007532842 cites W2066094871 @default.
• W2007532842 cites W2074548631 @default.
• W2007532842 cites W2076426515 @default.
• W2007532842 cites W2077163773 @default.
• W2007532842 cites W2088641817 @default.
• W2007532842 cites W2091602444 @default.
• W2007532842 cites W2106782951 @default.
• W2007532842 cites W2111486924 @default.
• W2007532842 cites W2146213605 @default.
• W2007532842 cites W2161630603 @default.
• W2007532842 cites W2162258100 @default.
• W2007532842 cites W2241166952 @default.
• W2007532842 cites W2255018330 @default.
• W2007532842 cites W2322312023 @default.
• W2007532842 cites W232329795 @default.
• W2007532842 cites W2337261696 @default.
• W2007532842 cites W2340198921 @default.
• W2007532842 cites W2341591060 @default.
• W2007532842 cites W2343863476 @default.
• W2007532842 cites W2402865559 @default.
• W2007532842 cites W2410161408 @default.
• W2007532842 cites W4251365833 @default.
• W2007532842 cites W60627455 @default.
• W2007532842 cites W97384583 @default.
• W2007532842 doi "https://doi.org/10.1056/nejm198907203210302" @default.
• W2007532842 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2787477" @default.
• W2007532842 hasPublicationYear "1989" @default.
• W2007532842 type Work @default.
• W2007532842 sameAs 2007532842 @default.
• W2007532842 citedByCount "427" @default.
• W2007532842 countsByYear W20075328422012 @default.
• W2007532842 countsByYear W20075328422013 @default.
• W2007532842 countsByYear W20075328422014 @default.
• W2007532842 countsByYear W20075328422015 @default.
• W2007532842 countsByYear W20075328422016 @default.
• W2007532842 countsByYear W20075328422017 @default.
• W2007532842 countsByYear W20075328422019 @default.
• W2007532842 countsByYear W20075328422020 @default.
• W2007532842 countsByYear W20075328422021 @default.
• W2007532842 countsByYear W20075328422022 @default.
• W2007532842 countsByYear W20075328422023 @default.
• W2007532842 crossrefType "journal-article" @default.
• W2007532842 hasAuthorship W2007532842A5007275246 @default.
• W2007532842 hasAuthorship W2007532842A5012776569 @default.
• W2007532842 hasAuthorship W2007532842A5014628209 @default.
• W2007532842 hasAuthorship W2007532842A5017212847 @default.
• W2007532842 hasAuthorship W2007532842A5018363328 @default.
• W2007532842 hasAuthorship W2007532842A5019589871 @default.
• W2007532842 hasAuthorship W2007532842A5030075618 @default.
• W2007532842 hasAuthorship W2007532842A5043440650 @default.
• W2007532842 hasAuthorship W2007532842A5044283278 @default.
• W2007532842 hasAuthorship W2007532842A5054646389 @default.
• W2007532842 hasAuthorship W2007532842A5059983011 @default.
• W2007532842 hasAuthorship W2007532842A5075827511 @default.
• W2007532842 hasConcept C104317684 @default.
• W2007532842 hasConcept C126322002 @default.
• W2007532842 hasConcept C142724271 @default.

• next