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• W2007534014 abstract "Dichloromethane and methanol extracts of seven different food and medicinal plants were tested in a screening platform for identification of extracts with potential bioactivity related to insulin-dependent glucose uptake and fat accumulation. The screening platform included a series of in vitro bioassays, peroxisome proliferator-activated receptor (PPAR) γ -mediated transactivation, adipocyte differentiation of 3T3-L1 cell cultures, and glucose uptake in both 3T3-L1 adipocytes and primary porcine myotubes, as well as one in vivo bioassay, fat accumulation in the nematode Caenorhabditis elegans . We found that dichloromethane extracts of aerial parts of golden root ( Rhodiola rosea ) and common elder ( Sambucus nigra ) as well as the dichloromethane extracts of thyme ( Thymus vulgaris ) and carrot ( Daucus carota ) were able to stimulate insulin-dependent glucose uptake in both adipocytes and myotubes while weekly activating PPAR γ without promoting adipocyte differentiation. In addition, these extracts were able to decrease fat accumulation in C. elegans . Methanol extracts of summer savory ( Satureja hortensis ), common elder, and broccoli ( Brassica oleracea ) enhanced glucose uptake in myotubes but were not able to activate PPAR γ , indicating a PPAR γ -independent effect on glucose uptake." @default.
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• W2007534014 date "2014-01-01" @default.
• W2007534014 modified "2023-10-17" @default.
• W2007534014 title "Screening for Bioactive Metabolites in Plant Extracts Modulating Glucose Uptake and Fat Accumulation" @default.
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• W2007534014 doi "https://doi.org/10.1155/2014/156398" @default.
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