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- W2007536372 abstract "Background: A promising paradigm in human neuroimaging is the study of slow (<0.1 Hz) spontaneous fl uctuations in the hemodynamic response measured by functional magnetic resonance imaging (fMRI). Spontaneous activity (i.e., resting state) refers to activity that cannot be attributed to specifi c inputs or outputs, that is, activity intrinsically generated by the brain. Method: This article presents pilot data examining neural connectivity in patients with poststroke hemiparesis before and after 3 weeks of upper extremity rehabilitation in the Accelerated Skill Acquisition Program (ASAP). Resting-state fMRI data acquired pre and post therapy were analyzed using an exploratory adaptation of structural equation modeling (SEM) to evaluate therapy-related changes in motor network effective connectivity. Results: Each ASAP patient showed behavioral improvement. ASAP patients also showed increased infl uence of the affected hemisphere premotor cortex (a-PM) upon the unaffected hemisphere premotor cortex (u-PM) following therapy. The infl uence of a-PM on affected hemisphere primary motor cortex (a-M1) also increased with therapy for 3 of 5 patients, including those with greatest behavioral improvement. Conclusions: Our fi ndings suggest that network analyses of resting-state fMRI constitute promising tools for functional characterization of functional brain disorders, for intergroup comparisons, and potentially for assessing effective" @default.
- W2007536372 created "2016-06-24" @default.
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- W2007536372 date "2009-07-01" @default.
- W2007536372 modified "2023-10-17" @default.
- W2007536372 title "Changes in Resting State Effective Connectivity in the Motor Network Following Rehabilitation of Upper Extremity Poststroke Paresis" @default.
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- W2007536372 doi "https://doi.org/10.1310/tsr1604-270" @default.
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