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• W2007545008 abstract "The present study was undertaken to investigate the effect of JT3002, a new synthetic analogue of a lipoprotein from the outer wall of a gram-negative bacterium on the production of cytokines by mouse peritoneal macrophages. Multilamellar liposomes containing different concentrations of JT3002 induced production of the inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 alpha, and interleukin-6 by macrophages in dose- and time-dependent manners. The presence of interferon-gamma enhanced production of tumor necrosis factor-alpha by macrophages exposed to lower concentrations of JT3002 and induced the release of nitric oxide, a potent cytolytic molecule of activated macrophages. Unlike lipopolysaccharide, JT3002 activated macrophages independently of serum, but like lipopolysaccharide, it required protein tyrosine kinase." @default.
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• W2007545008 date "1997-10-01" @default.
• W2007545008 modified "2023-09-25" @default.
• W2007545008 title "Expression of Inflammatory Cytokines by Murine Macrophages Activated with a New Synthetic Lipopeptide JT3002" @default.
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• W2007545008 doi "https://doi.org/10.1089/cbr.1997.12.333" @default.
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