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• W2007570344 abstract "Abstract. Complement-fixing adrenal medulla (CF-ADM), sympathetic ganglion (CF-SG), and vagal (CF-V) nerve antibodies were determined in diabetic patients. Among 74 patients with Type 1 diabetes, CF-ADM was detected in 7 (10%) cases, CF-SG in 14 (19%) cases, and CF-V in 8 (11%) cases. Among 38 patients with Type 2 diabetes, CF-ADM was detected in 5 (13%) cases, CF-SG in 4 (11%) cases, and CF-V in 6 (16%) cases. There were associations between autonomic nerve antibodies and autonomic nerve function. CF-ADM and/or CF-SG were significantly (P < 0.002) less prevalent in Type 1 diabetic patients with autonomic neuropathy than in those without [5/44 (11%) vs. 14/30 (47%)] and, in agreement with this, the brake index, a sign of parasympathetic and sympathetic autonomic nerve function, was significantly (P < 0.005) higher (more normal) in these patients (–0.56 ± 0.13 vs. –1.04 ± 0.12). In Type 2 diabetic patients, the E/I ratio, an index of parasympathetic nerve function, was significantly (P < 0.03) lower (more abnormal) in those with CF-V than in those without (–1.81 ± 0.17 vs. –1.20 ± 0.11). In conclusion, the frequency of sympathetic nerve antibodies was decreased in Type 1 diabetic patients with autonomic neuropathy, while in Type 2 diabetic patients parasympathetic nerve antibodies were related to severe parasympathetic neuropathy." @default.
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• W2007570344 date "1991-06-01" @default.
• W2007570344 modified "2023-10-16" @default.
• W2007570344 title "Autonomic nerve antibodies and autonomic nerve function in Type 1 and Type 2 diabetic patients" @default.
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• W2007570344 doi "https://doi.org/10.1111/j.1365-2796.1991.tb00386.x" @default.
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